Newest studies

Disrupted structural and functional brain networks in Alzheimer's disease

46/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: Studies have demonstrated that the clinical manifestations of Alzheimer's disease (AD) are associated with abnormal connections in either functional connectivity networks (FCNs) or structural connectivity networks (SCNs). +3 more findings

• Brain Scans

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Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia

45/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

Key finding: VaD is usually caused by cerebrovascular disease, during which, cerebrovascular endothelial cells (CECs) are vulnerable. +4 more findings

• Other Dementias
• Brain Biology

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Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

39/100 ✓ Peer-reviewed Disease mechanisms Cell death and differentiation

Key finding: Imbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies. +2 more findings

• Brain Biology

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Soluble LR11 competes with amyloid β in binding to cerebrospinal fluid-high-density lipoprotein

46/100 ✓ Peer-reviewed Tau biomarkers Clinica chimica acta; international journal of clinical chemistry

Key finding: CSF-sLR11 concentrations were higher in patients with AD than controls (adjusted for sLR11 using phospholipid). +2 more findings

• Biomarkers

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Retinal image analytics detects white matter hyperintensities in healthy adults

57/100 ✓ Peer-reviewed Treatments Annals of clinical and translational neurology

Key finding: We developed a robust algorithm to automatically evaluate retinal fundus image that can identify subjects with high WMH burden. +2 more findings

• Brain Scans
• Risk Factors

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Microglia in Alzheimer's Disease: Risk Factors and Inflammation

41/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in neurology

Key finding: Recent genetic studies have suggested that microglial function is compromised in Alzheimer's disease (AD), and that environmental factors such as diet and brain injury also affect microglial activation. +1 more finding

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

The association between PM2.5 exposure and neurological disorders: A systematic review and meta-analysis

66/100 ✓ Peer-reviewed Vascular contributions The Science of the total environment

Key finding: There is a strong association between PM 2.5 exposure and neurological disorders. +3 more findings

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Identification of Mild Cognitive Impairment From Speech in Swedish Using Deep Sequential Neural Networks

42/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology

Key finding: To learn the acoustic characteristics associated with MCI vs. healthy controls, we have trained and evaluated ten Deep Neural Network Architectures and measured how accurately they can diagnose participants that are unknown to the model. +1 more finding

• Digital Tools
• Early Stage

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Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) in the elderly?

66/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics

Key finding: ABSTRACTObjective:To compare the accuracy of Mini-Mental State Examination (MMSE) and of the Montreal Cognitive Assessment (MoCA) in tracking mild cognitive impairment (MCI) and Alzheimer's Disease (AD). +1 more finding

• Diagnosis
• Early Stage

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Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer's Disease

41/100 ✓ Peer-reviewed Disease mechanisms Nutrients

Key finding: Increasing numbers of studies suggest that the gut microbiota can influence the brain and behavior of patients.

• Brain Biology

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proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

41/100 ✓ Peer-reviewed Disease mechanisms Molecular brain

Key finding: In AD patients we observe a significative increase of proBDNF and Sortilin expression and a significative increase of the ratio proBDNF/BDNF in their cerebrospinal fluid compared to controls. +1 more finding

• Brain Biology

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CSF1R-related leukoencephalopathy: A major player in primary microgliopathies

50/100 ✓ Peer-reviewed Inflammation and the immune system Neurology

Key finding: Through the analyses of mutation carriers, CSF1R -related leukoencephalopathy has been distinctly characterized clinically, radiologically, and pathologically. +3 more findings

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Speech Analysis by Natural Language Processing Techniques: A Possible Tool for Very Early Detection of Cognitive Decline?

52/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

Key finding: Neuropsychological tests showed significant differences between controls and mdMCI, and between controls and eD participants; GPCog, MoCA, PF, and SF also discriminated between controls and aMCI. +4 more findings

• Diagnosis

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The S100B story: from biomarker to active factor in neural injury

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

Key finding: Although the wide spectrum of diseases in which the protein is involved (acute brain injury, neurodegenerative diseases, congenital/perinatal disorders, psychiatric disorders) reduces its specificity, its levels remain an important aid in monitoring the trend of the disorder. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Incident Hearing Loss and Comorbidity

59/100 ✓ Peer-reviewed Health systems and care delivery JAMA Otolaryngology–Head & Neck Surgery

Key finding: After cohort matching, 48% of participants were women (n = 74 464), 61% were white (n = 93 442), and 31% (n = 48 056) were Medicare Advantage insured, with a mean (SD) age of 64 (10) years. +4 more findings

• Risk Factors

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Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Murine microglia expressing the Alzheimer's disease-linked TREM2 R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. +3 more findings

• Genetics
• Brain Biology

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Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

38/100 ✓ Peer-reviewed Drug development Neuropharmacology

Key finding: Palm 11 -PrRP31 also significantly reduced hippocampal microgliosis, consistent with our observations of a reduced Aβ plaque load, and reduced cortical astrocytosis, similar to the treatment with liraglutide. +3 more findings

• Brain Biology
• Treatments
• Risk Factors

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Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population

41/100 ✓ Peer-reviewed Genetics Social science & medicine (1982)

Key finding: We selected 39 genes that had significant, replicated associations with cognition, dementia, and related traits in published GWAS. +4 more findings

• Genetics

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Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia

43/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: Solanezumab produced statistically significant increases in CSF total Aβ isoforms versus placebo, which correlated with CSF solanezumab concentration. +3 more findings

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Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

55/100 ✓ Peer-reviewed Risk factors Therapeutic advances in chronic disease

Key finding: The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. +2 more findings

• Risk Factors

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Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The forms of tau in CSF and plasma are distinct, but in each specimen type, the levels of certain fragments are increased in AD.

• Biomarkers

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Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems

55/100 ✓ Peer-reviewed How common it is Chest

Key finding: Air pollution is associated with reduced cognitive function and increased risk of dementia. +3 more findings

• Risk Factors

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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease

38/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Deletion of C3ar1 in PS19 mice results in the rescue of tau pathology and attenuation of neuroinflammation, synaptic deficits, and neurodegeneration. +1 more finding

• Brain Biology

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A Mediterranean diet supplemented with dairy foods improves mood and processing speed in an Australian sample: results from the MedDairy randomized controlled trial

71/100 ✓ Peer-reviewed Prevention trials Nutritional neuroscience

Key finding: Our study provides evidence that a Mediterranean diet supplemented with dairy foods may benefit cognitive function and psychological well-being in an ageing population at risk of dementia. +1 more finding

• Clinical Trials
• Lifestyle
• Risk Factors

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The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies

66/100 ✓ Peer-reviewed Risk factors Sleep medicine reviews

Key finding: The risk for developing neurodegenerative diseases was 33.5% at five years follow-up, 82.4% at 10.5 years and 96.6% at 14 years. +4 more findings

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source