Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,601–11,625 of 27,380 studies, newest first · page 465 of 1096.
May 2020 25
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2020-05-27
Structures of α-synuclein filaments from multiple system atrophy
43/100 ✓ Peer-reviewed Brain tissue and pathology Nature
Key finding: Using two-dimensional class averaging, we show that α-synuclein filaments from the brains of individuals with MSA differ from those of individuals with DLB, which suggests that distinct conformers or strains characterize specific synucleinopathies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-26
Mitigating the Effects of a Pandemic: Facilitating Improved Nursing Home Care Delivery Through Technology
39/100 ✓ Peer-reviewed Health systems and care delivery JMIR aging
Key finding: Residents are experiencing social isolation, which can result in physical and behavioral health issues, particularly for persons with dementia.
Full summary, score breakdown and related studies → Original source
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2020-05-26
Ageing without dementia: can stimulating psychosocial and lifestyle experiences make a difference?
43/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: Evidence from observational studies is robust enough to suggest that stimulating psychosocial and lifestyle factors are protective against dementia.
Full summary, score breakdown and related studies → Original source
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2020-05-26
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
53/100 ✓ Peer-reviewed Brain scans and imaging Nature communications
Key finding: Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-26
Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies
69/100 ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)
Key finding: Overall, stronger associations were found in midlife than late-life. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-26
Effect of ApoE isoforms on mitochondria in Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: ApoE isoforms influence mitochondrial structure and function, which likely leads to alteration in oxidative stress, synapses, and cognitive function. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-26
Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study
63/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology
Key finding: We enrolled a cohort of 1070 PSEN1 E280A mutation carriers and 1074 non-carriers with baseline assessments; of these participants, longitudinal measures (with a mean follow-up of 6 years) were available for 242 mutation carriers and 262 non-carriers.
Full summary, score breakdown and related studies → Original source
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2020-05-25
APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort
59/100 ✓ Peer-reviewed Clinical safety The Journals of Gerontology Series A
Key finding: In older adults, we found that pre-existing dementia is a major risk factor (OR = 3.07, 95% CI: 1.71 to 5.50) for COVID-19 hospitalization in the UK Biobank (UKB). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-25
Recent trends in mental illness and omega-3 fatty acids
39/100 ✓ Peer-reviewed Prevention and risk Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Following a report by Hibbeln (Lancet 351:1213, 1998) published in The Lancet, which suggested that depression rates and fish consumption were inversely correlated, the relationships between a variety of nutritional/epidemiological treatments and neuropsychiatric disorders have received increased attention.
Full summary, score breakdown and related studies → Original source
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2020-05-25
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
44/100 ✓ Peer-reviewed TREM2 and immune genetics Glia
Key finding: Treatment with PLX5622, an inhibitor of colony stimulating factor 1 receptor (CSF1R) that efficiently depletes microglia, prior to infection of the central nervous system (CNS) with the neurotropic JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality compared with control mice that correlated with impaired control of viral replication. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-22
Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis
78/100 ✓ Peer-reviewed Drug development Metabolism: clinical and experimental
Key finding: This analysis indicated that patients with type 2 diabetes under treatment with DPP-4 inhibitors presented with the lowest risk of dementia, followed by those treated with metformin and thiazolidinedione, while treatment with insulin was associated with the highest risk. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-22
Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer's Disease Neuroimaging Initiative
43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Twenty-three patients with mild cognitive impairment (MCI), 12 dementia of Alzheimer's type (DAT), and 14 normal controls were studied following the ADNI2 protocol. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-21
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia
42/100 ✓ Peer-reviewed TREM2 and immune genetics Genes & diseases
Key finding: Rare variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing AD, suggesting the involvement of TREM2 and innate immunity in AD development. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-21
The late stage of Parkinson's -results of a large multinational study on motor and non-motor complications
46/100 ✓ Peer-reviewed Digital health tools Parkinsonism & related disorders
Key finding: These data suggest that current treatment of late stage parkinsonism in the community remains insufficiently effective to alleviate disabling symptoms in many patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-20
Polygenic risk and pleiotropy in neurodegenerative diseases
39/100 ✓ Peer-reviewed Genetics Neurobiology of disease
Key finding: We conclude that the exploitation of pleiotropy may aid in the identification of novel genes and provide further insights in the disease mechanisms, and along with PRS analysis, may be advantageous for precision medicine.
Full summary, score breakdown and related studies → Original source
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2020-05-20
A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease
51/100 ✓ Peer-reviewed Disease mechanisms Scientific reports
Key finding: We found that only the calcium signalling pathway enriched by 48 downregulated genes was consistent between all three studies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-20
Depression-an underrecognized target for prevention of dementia in Alzheimer's disease
54/100 ✓ Peer-reviewed Prevention and risk Translational psychiatry
Key finding: While several recent guidelines and multidomain intervention trials on prevention of cognitive decline address lifestyle factors and risk diseases, such as hypertension and diabetes, a special reference to the established risk factor of depression or depressive symptoms is systematically lacking. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-19
Technology Literacy as a Barrier to Telehealth During COVID-19
76/100 ✓ Peer-reviewed Cognitive tests and assessment Telemedicine Journal and e-Health
Key finding: Prior work has shown that the video component significantly contributes to quality and satisfaction of the visit.3 In addition to the technology itself, patients need to know what to expect for their telehealth appointments. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-19
Increased apolipoprotein E and decreased TNF-α in the cerebrospinal fluid of nondemented APOE-ε4 carriers
46/100 ✓ Peer-reviewed Genetics Neuropsychopharmacology reports
Key finding: CSF levels of apoE2, apoE3, and apoE4 were significantly higher (all nominal P < 10 × 10-5 , false discovery rate < 0.001) and those of tumor necrosis factor-α (TNF-α) were significantly lower (nominal P = 1.39 × 10-6 , false discovery rate < 0.001) in APOE-ε4 carriers than in noncarriers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-19
How to do things with (thousands of) words: Computational approaches to discourse analysis in Alzheimer's disease
41/100 ✓ Peer-reviewed Digital health tools Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: The study of Alzheimer's disease (AD), and preclinical Mild Cognitive Impairment (MCI), suggests that changes in discourse (connected speech or writing) may be key to early detection of disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-19
Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis
85/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: In this meta-analysis of randomized clinical trials, blood pressure lowering with antihypertensive agents compared with control was significantly associated with a lower risk of incident dementia or cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-18
Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer's disease
50/100 ✓ Peer-reviewed Tau biomarkers Aging
Key finding: To investigate whether the CSF Ng can be used for diagnosis, prognosis, and monitoring of AD, we examined 111 cognitively normal (CN) controls, 193 mild cognitive impairment (MCI) patients and 95 AD patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-17
[The cognitive-behavioural impact of hypertension]
39/100 ✓ Peer-reviewed Risk factors Hipertension y riesgo vascular
Key finding: Arterial hypertension is considered the main modifiable vascular risk factor that causes silent damage to brain vessels. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-17
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Aging cell
Key finding: Biological network analysis further revealed H3K9me3-landscaped epigenomes to be mainly involved in synaptic transmission, neuronal differentiation, and cell motility. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-05-16
Characteristics and Outcomes of Dementia Patients Who Receive Inpatient Palliative Care Consultation
52/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Among 927 hospitalized patients with dementia, 17% received IPCC (N = 157). +4 more findings
Full summary, score breakdown and related studies → Original source
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