Newest studies

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

47/100 ✓ Peer-reviewed Cognitive tests and assessment The Journal of comparative neurology

Key finding: We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia from a cohort of people enrolled in the Religious Orders Study. +3 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

The mini-cog: a cognitive 'vital signs' measure for dementia screening in multi-lingual elderly

51/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: The Mini-Cog, a composite of three-item recall and clock drawing, was developed as a brief test for discriminating demented from non-demented persons in a community sample of culturally, linguistically, and educationally heterogeneous older adults. +3 more findings

• Diagnosis

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Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions

59/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

Key finding: Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of these disorders. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cognition and synaptic plasticity in diabetes mellitus

46/100 ✓ Peer-reviewed Risk factors Trends in neurosciences

Key finding: Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Phonological and articulatory impairment in Alzheimer's disease: a case series

47/100 ✓ Peer-reviewed Digital health tools Brain and language

Key finding: Analysis of their conversational speech, single-word production, and performance of highly familiar series speech tasks such as counting revealed false start errors, phonological paraphasias, and/or articulatory difficulty.

Full summary, score breakdown and related studies → Original source

Are memory complaints predictive for dementia? A review of clinical and population-based studies

56/100 ✓ Peer-reviewed How common it is International journal of geriatric psychiatry

Key finding: Memory complaints in elderly people should no longer be considered merely as an innocent age-related phenomenon or a symptom of depression. +1 more finding

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Neuropathologic substrates of ischemic vascular dementia

59/100 ✓ Peer-reviewed Caregiving Journal of neuropathology and experimental neurology

Key finding: Ischemic vascular dementia (IVD) is a relatively uncommon entity, in the course of which multiple ischemic brain lesions result in progressive cognitive and memory impairment. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging

59/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Incidence of parkinsonism and PD increased with age, PD was the most common type of parkinsonism, and men had a risk of developing PD twice that of women. +1 more finding

• Diagnosis
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Statins and the risk of dementia

68/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)

Key finding: The study encompassed 284 cases with dementia and 1080 controls.

• Risk Factors

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Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease

55/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: CST3 is a susceptibility gene for late-onset AD, especially in patients aged 75 years and older. +1 more finding

• Genetics

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Identifying subgroups of the general population that may be susceptible to short-term increases in particulate air pollution: a time-series study in Montreal, Quebec

40/100 ✓ Peer-reviewed Risk factors PubMed

Key finding: The objectives of the study were (1) to determine whether concentrations of particles in the ambient air of Montreal, Quebec, were associated with daily all-cause and cause-specific mortality in the period 1984 to 1993, and (2) to determine whether groups of the population had higher than average risks of death from exposure to particles. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Medicinal Plants and Phytomedicines. Linking Plant Biochemistry and Physiology to Human Health

36/100 ✓ Peer-reviewed Risk factors PLANT PHYSIOLOGY

Key finding: The beneficial medicinal effects of plant materials typically result from the combinations of secondary products present in the plant. +4 more findings

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High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation

36/100 ✓ Peer-reviewed Genetics Electrophoresis

Key finding: Recent studies have demonstrated the need for complementing cellular genomic information with specific information on expressed proteins, or proteomics, since the correlation between the two is poor.

• Brain Biology

Full summary, score breakdown and related studies → Original source

The detection of dementia in the primary care setting

50/100 ✓ Peer-reviewed Disparities Archives of internal medicine

Key finding: Dementia is often unrecognized and undocumented in private practice settings.

• Care Services

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Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging

52/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry

Key finding: Relative to normal controls, patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

40/100 ✓ Peer-reviewed Biomarkers Brain research

Key finding: Basal ganglia involvement in HIV-1 infection may be responsible for some of the psychomotor symptoms associated with HIV dementia. +4 more findings

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The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: A number of studies indicate that prolonged, major depression is associated with a selective loss of hippocampal volume that persists long after the depression has resolved. +1 more finding

• Brain Biology

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Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

Key finding: An extensive literature stretching back decades has shown that prolonged stress or prolonged exposure to glucocorticoids-the adrenal steroids secreted during stress-can have adverse effects on the rodent hippocampus. +4 more findings

• Brain Scans

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Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

49/100 ✓ Peer-reviewed Risk factors Archives of Neurology

There is a lower prevalence of diagnosed probable AD in patients taking 2 different 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors-lovastatin and pravastatin.

• Risk Factors

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Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study

62/100 ✓ Peer-reviewed Caregiving Arteriosclerosis, thrombosis, and vascular biology

Key finding: The z-score sum was higher in demented subjects than in nondemented subjects, indicating a higher risk factor burden (0.74 versus -0.06, respectively; P=0. 008). +1 more finding

• Risk Factors

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Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias

59/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Moderate and severe head injuries in young men may be associated with increased risk of AD and other dementias in late life. +3 more findings

• Risk Factors

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Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: a double-blind, randomized, placebo-controlled trial. The HGEU Study Group

66/100 ✓ Peer-reviewed Treatments Archives of general psychiatry

Key finding: Patients with Alzheimer disease (AD) commonly exhibit psychosis and behavioral disturbances that impair patient functioning, create caregiver distress, and lead to institutionalization.

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism

43/100 ✓ Peer-reviewed Disparities American journal of human genetics

Key finding: Sequence analysis of the chimpanzee APOE gene showed that it was most closely related to human epsilon4-type haplotypes, differing from the human consensus sequence at 67 synonymous (54 substitutions and 13 indels) and 9 nonsynonymous fixed positions. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Measuring the thickness of the human cerebral cortex from magnetic resonance images

57/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences

Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Olfactory Deficits in Patients With Mild Cognitive Impairment Predict Alzheimer’s Disease at Follow-Up

47/100 ✓ Peer-reviewed Risk factors American Journal of Psychiatry

Key finding: Olfaction scores were lower in patients with mild cognitive impairment than in healthy comparison subjects. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source