Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,876–12,900 of 27,380 studies, newest first · page 516 of 1096.
May 2019 14
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2019-05-01
Understanding the factors associated with patients with dementia achieving their preferred place of death: a retrospective cohort study
69/100 ✓ Peer-reviewed End-of-life care Age and ageing
Key finding: Little is known about preferred place of death, or the factors associated with achieving this, for people with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA)
41/100 ✓ Peer-reviewed Clinical safety The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: A standardized assessment battery that captures shared characteristics of mobility and cognition seen in aging and neurodegeneration may increase comparability across research studies, detection of subtle or common reversible factors, and accelerate research progress in dementia, falls, and aging-related disabilities.
Full summary, score breakdown and related studies → Original source
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2019-05-01
Single-cell transcriptomic analysis of Alzheimer’s disease
64/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: Across six major brain cell types, we identified transcriptionally distinct subpopulations, including those associated with pathology and characterized by regulators of myelination, inflammation, and neuron survival. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study
54/100 ✓ Peer-reviewed Long-term cohort studies Aging
Key finding: Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia
43/100 ✓ Peer-reviewed TREM2 and immune genetics Cell reports
Key finding: However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Caregiving Across Diverse Populations: New Evidence From the National Study of Caregiving and Hispanic EPESE
47/100 ✓ Peer-reviewed Disparities Innovation in aging
Key finding: Caregiving intensity is related to health for non-Latino White CGs and African American dementia CGs.
Full summary, score breakdown and related studies → Original source
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2019-05-01
Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults
57/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Sensory impairments were common: 28% had visual impairment, 35% had hearing loss, 22% had poor smell, 12% had touch insensitivity; 26% had more than two impairments, and 5.6% had more than three sensory impairments. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-01
The Association Between Gait Speed and Cognitive Status in Community-Dwelling Older People: A Systematic Review and Meta-analysis
70/100 ✓ Peer-reviewed Prevention and risk The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: The strength of evidence for an association between gait speed and cognition was demonstrated by the number and consistency of results, as well as quality of the studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data
75/100 ✓ Peer-reviewed Prevention and risk The Lancet. Global health
Key finding: The overall weighted PAF for potentially modifiable risk factors for dementia was 39·5% (95% CI 37·5-41·6) in China (n=2162 participants), 41·2% (39·1-43·4) in India (n=2004), and 55·8% (54·9-56·7) in our Latin American sample (n=12 865). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-05-01
Obesity: global epidemiology and pathogenesis
53/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Endocrinology
Key finding: Obesity is also associated with unemployment, social disadvantages and reduced socio-economic productivity, thus increasingly creating an economic burden.
Full summary, score breakdown and related studies → Original source
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2019-05-01
Blood Pressure Lowering With Nilvadipine in Patients With Mild-to-Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension
61/100 ✓ Peer-reviewed Treatments Journal of the American Heart Association
Key finding: This study suggests that initiation of a low dose of antihypertensive treatment does not significantly increase the risk of OH in patients with mild-to-moderate Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Effect of Milk and Other Dairy Products on the Risk of Frailty, Sarcopenia, and Cognitive Performance Decline in the Elderly: A Systematic Review
63/100 ✓ Peer-reviewed Treatments Advances in nutrition (Bethesda, Md.)
Key finding: Consumption of milk at midlife may be negatively associated with verbal memory performance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults
66/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Early tau deposition was elevated in women compared with men in individuals on the Alzheimer disease trajectory. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-01
Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes
72/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Among the 1453 participants in the Framingham dementia study sample, the mean (SD) age was 75 (7) years; 792 (54.5%) were female. +2 more findings
Full summary, score breakdown and related studies → Original source
April 2019 11
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2019-04-30
Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials
41/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.
Full summary, score breakdown and related studies → Original source
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2019-04-30
Inflammatory biomarkers in Alzheimer's disease plasma
61/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI.
Full summary, score breakdown and related studies → Original source
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2019-04-30
Prediction of Alzheimer's disease dementia with MRI beyond the short-term: Implications for the design of predictive models
42/100 ✓ Peer-reviewed Digital health tools NeuroImage. Clinical
Key finding: Our results indicate that 23% of the stable MCI at 2 years progressed in the next three years and that MRI volumetric measures are good predictors of conversion to AD dementia even at the mid-term, showing a better specificity and AUC as follow-up time increases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-29
Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy
41/100 ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: It is frequently accompanied by Alzheimer's disease and causes dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-29
Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq
46/100 ✓ Peer-reviewed TREM2 and immune genetics Cancer medicine
Key finding: Molecular cues from the tumor microenvironment promote the differentiation of immature myeloid cells toward an immunosuppressive phenotype. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-28
Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes
39/100 ✓ Peer-reviewed Disease mechanisms Autophagy
Key finding: Abnormal accumulation of proteins is a hallmark of a variety of neurological diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-28
Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults
59/100 ✓ Peer-reviewed Prevention trials Nutrients
Key finding: In an additional analysis stratifying the sample by weight status, the association between sleep quality and high adherence to the Mediterranean diet was observed only among normal/overweight individuals but not in obese participants. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-26
Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
41/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in physiology
Key finding: The importance of these cells for neuronal survival has previously been studied in co-culture experiments and the search for neurotrophic factors (NTFs) initiated after finding that the addition of conditioned media from astrocyte cultures could support the survival of primary neurons in vitro . +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-25
Pancreatic islet (of Langerhans) revisited
39/100 ✓ Peer-reviewed Drug development Histology and histopathology
Key finding: The increasing prevalence of obesity, diabetes and Alzheimer's disease in the population (three conditions that are linked to pancreatic islet function), the islet has been playing a significant role in endocrinological and metabolic studies searching how we can protect the pancreatic islet and its cell content, or how we can regenerate it.
Full summary, score breakdown and related studies → Original source
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2019-04-25
Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations
45/100 ✓ Peer-reviewed Vascular contributions Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: It is generally accepted that endothelial dysfunction, including blood-brain barrier (BBB) failure, is pivotal in the pathophysiology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-25
Prolong treatment with Trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type
35/100 ✓ Peer-reviewed Biomarkers Neurotoxicology
Key finding: Alzheimer disease has been well associated with mitochondrial dysfunctions. +2 more findings
Full summary, score breakdown and related studies → Original source
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