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A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia
Ash S, Nevler N, Phillips J, Irwin DJ, McMillan CT, Rascovsky K, Grossman M.. Brain and language, 2019-05-07
Topic: Risk, prevention and care in population studies
We examined longitudinal change in language expression during a semi-structured speech sample in 48 patients with primary progressive aphasia (PPA) or behavioral variant frontotemporal dementia (bvFTD) and related this to longitudinal neuroimaging of cortical thickness available in 25 of these patients. All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD. These patient groups also declined on several neuropsychological measures, but there was no correlation between decline in speech expression and decline in neuropsychological performance. Longitudinal decline in grammaticality, assessed by the number of well-formed sentences produced, was associated with longitudinal progression of gray matter atrophy in left frontal operculum/insula and bilateral temporal cortex.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ash, S., Nevler, N., Phillips, J., Irwin, D. J., McMillan, C. T., Rascovsky, K., et al. (2019). A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia. Brain and language. https://doi.org/10.1016/j.bandl.2019.04.006
Vancouver
Ash S, Nevler N, Phillips J, Irwin DJ, McMillan CT, Rascovsky K, et al. A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia. Brain and language. 2019. doi:10.1016/j.bandl.2019.04.006. PMID: 31075725.
BibTeX
@article{ash2019-31075725,
author = {Ash, S. and Nevler, N. and Phillips, J. and Irwin, D. J. and McMillan, C. T. and Rascovsky, K. and Grossman, M.},
title = {{A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia}},
journal = {Brain and language},
year = {2019},
doi = {10.1016/j.bandl.2019.04.006},
pmid = {31075725},
url = {https://doi.org/10.1016/j.bandl.2019.04.006}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD.
- Longitudinal decline in grammaticality, assessed by the number of well-formed sentences produced, was associated with longitudinal progression of gray matter atrophy in left frontal operculum/insula and bilateral temporal cortex.
Why it matters
In this longitudinal study, all patient groups declined significantly on measures of speech fluency and grammar, with nonfluent/agrammatic PPA declining more than other variants and bvFTD. Decline in grammaticality was linked to progression of gray matter atrophy in left frontal operculum/insula and bilateral temporal cortex, but there was no correlation between speech decline and neuropsychological performance decline.
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Study details
- Study designlongitudinal study
- Participants48
- Evidence strengthModerate
How this study scored 55/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain and language) |
| Journal's citation record | 2 / 4 | Brain and Language: journal h-index 214 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 48 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 48 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.3 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Murray Grossman: h-index 119 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31075725) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.bandl.2019.04.006
- PubMed: 31075725
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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