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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,726–12,750 of 27,380 studies, newest first · page 510 of 1096.

June 2019 25

  1. 2019-06-27

    A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system Cell metabolism

    Key finding: Here, using metabolic profiling, we found that exposure to amyloid-β triggers acute microglial inflammation accompanied by metabolic reprogramming from oxidative phosphorylation to glycolysis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-06-27

    Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

    ✓ Peer-reviewed TREM2 and immune genetics Cell

    Key finding: Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-06-27

    Brain age in bipolar disorders: Effects of lithium treatment

    ✓ Peer-reviewed Digital health tools The Australian and New Zealand journal of psychiatry

    Key finding: Bipolar disorders were associated with greater, whereas Li treatment with lower discrepancy between brain and chronological age. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-06-27

    Prevalence of depression among the elderly (60 years and above) population in India, 1997-2016: a systematic review and meta-analysis

    ✓ Peer-reviewed Disparities BMC public health

    Key finding: Fifty-one studies from 16 States of India were included as 56 datasets, which estimated the prevalence of depression among Indian elderly population as 34.4% (95% CI: 29.3-39.7).

    Full summary, score breakdown and related studies → Original source

  5. 2019-06-26

    Understanding the Role of Systemic Inflammation in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system ACS chemical neuroscience

    Key finding: Systemic inflammation, which is marked by increased blood levels of circulating proinflammatory cytokines and chemokines, may occur as a result of events such as infection, chronic disease, and physical and psychological stress, but may also occur outside the context of these conditions as a result of subclinical processes such as cellular senescence. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-06-25

    The use of zebrafish (Danio rerio) as biomedical models

    ✓ Peer-reviewed Disease mechanisms Animal Frontiers

    Key finding: Animal models provide consistency and validity of research results from in vitro studies or studies with rodents. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-06-25

    Approach Toward Diabetes Treatment in the Elderly

    ✓ Peer-reviewed Drug development Sisli Etfal Hastanesi tip bulteni

    Key finding: As a result, in elderly diabetics, an inadequate treatment or excessive treatment and individualizing the treatment should be the most appropriate approach.

    Full summary, score breakdown and related studies → Original source

  8. 2019-06-25

    Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

    ✓ Peer-reviewed Drug development Scientific reports

    Key finding: We have previously shown that delivery of an anti-tau antibody in a single-chain variable fragment (scFv) format to the brain is increased with SUS allowing for an enhanced therapeutic effect. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2019-06-24

    A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation

    ✓ Peer-reviewed TREM2 and immune genetics Dementia and neurocognitive disorders

    Key finding: Therapeutic strategies such as stratification (i.e., subgrouping of patients having similar clinical characteristics or genetic background) and personalized medicine could be set as new directions for developing effective drugs for AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-06-24

    Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

    ✓ Peer-reviewed Risk factors Lancet (London, England)

    Key finding: We compared the observed results with expected values estimated based on the Socio-demographic Index (SDI).

    Full summary, score breakdown and related studies → Original source

  11. 2019-06-24

    TREM2 function impedes tau seeding in neuritic plaques

    ✓ Peer-reviewed TREM2 and immune genetics Nature neuroscience

    Key finding: Here we show that germline knockout of Trem2 or the TREM2 R47H variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2019-06-22

    Do the posterior midline cortices belong to the electrophysiological default-mode network?

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: Our results identified the reconstruction method as the critical factor influencing PMC functional connectivity, which was significantly dampened by the Beamformer. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2019-06-22

    Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

    ✓ Peer-reviewed Drug development Molecules (Basel, Switzerland)

    Key finding: In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Aβ and tau.

    Full summary, score breakdown and related studies → Original source

  14. 2019-06-21

    Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

    ✓ Peer-reviewed Down syndrome and Alzheimer's Frontiers in neuroscience

    Key finding: Nevertheless, building on these findings, recent studies have provided an increasingly rich harvest of genetic, molecular and cellular data that are creating unprecedented opportunities to both understand and treat AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-06-20

    Connections Between Insomnia and Cognitive Aging

    ✓ Peer-reviewed Risk factors Neuroscience bulletin

    Key finding: Here, we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia, magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure, and interventional studies that have explored whether the treatment of insomnia can improve cognitive outcomes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2019-06-20

    Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

    ✓ Peer-reviewed Vascular contributions Science (New York, N.Y.)

    Key finding: We found that in humans with cognitive decline, amyloid β (Aβ) constricts brain capillaries at pericyte locations.

    Full summary, score breakdown and related studies → Original source

  17. 2019-06-20

    A comprehensive study of mobile-health based assistive technology for the healthcare of dementia and Alzheimer's disease (AD)

    ✓ Peer-reviewed Prevention trials Health care management science

    Key finding: The main groups are (1) activities of daily living (ADL) based cognitive training, (2) monitoring, (3) dementia screening, (4) reminiscence and socialization, (5) tracking, and (6) caregiver support. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-06-20

    Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model

    ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)

    Key finding: Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2019-06-20

    Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice

    ✓ Peer-reviewed TREM2 and immune genetics FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: We generated an embryonic deletion of Trem2 (whole body deletion) and induced hippocampal- and cortical-specific knockdown of microglial Trem2 at different stages of the AD process in amyloid precursor protein/Psen1 mice by adeno-associated virus (AAV) infection. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2019-06-19

    Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

    ✓ Peer-reviewed Disease mechanisms International journal of tryptophan research : IJTR

    Key finding: Prior to the production of NAD + , various intermediate compounds with neuroactivity (kynurenic acid, quinolinic acid) or antioxidant activity (3-hydroxykynurenine, picolinic acid) are synthesized. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2019-06-19

    Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

    ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage. Clinical

    Key finding: A key finding of the current study is a significant acceleration in the rate of hippocampal volume loss in middle age, more pronounced in females than in males.

    Full summary, score breakdown and related studies → Original source

  22. 2019-06-18

    Anosognosia Is Associated With Greater Caregiver Burden and Poorer Executive Function in Huntington Disease

    ✓ Peer-reviewed Caregiving Journal of geriatric psychiatry and neurology

    Key finding: Of the 38 patients recruited, 10 (26.3%) met criteria for anosognosia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2019-06-18

    Acquired cerebral amyloid angiopathy: An emerging concept

    ✓ Peer-reviewed Vascular contributions Progress in molecular biology and translational science

    Key finding: These findings suggest that transmission of Aβ seeds through dura mater grafts and other contaminated materials could lead to development of CAA.

    Full summary, score breakdown and related studies → Original source

  24. 2019-06-18

    Visual impairment in aging and cognitive decline: experience in a Memory Clinic

    ✓ Peer-reviewed Risk factors Scientific reports

    Key finding: Patients with Dementia, compared to those with SCD and MCI, presented worse visual acuity (p < 0.001), used less visual correction (p = 0.02 and p < 0.001, respectively) and fewer ophthalmological treatments (p = 0.004 and p < 0.001, respectively) and underwent fewer ocular surgeries (p = 0.009 and p < 0.001, respectively).

    Full summary, score breakdown and related studies → Original source

  25. 2019-06-17

    Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

    ✓ Peer-reviewed Risk factors Neurotoxicology

    Key finding: In these models, PM2.5 concentration was associated with smaller left hippocampal volume. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →