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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,601–12,625 of 27,380 studies, newest first · page 505 of 1096.

August 2019 16

  1. 2019-08-01

    The pro-remyelination properties of microglia in the central nervous system

    ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neurology

    Key finding: Microglial activation is a common feature of neurological disorders, and although in some instances this activation can be damaging, protective and regenerative functions of microglia have been revealed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-08-01

    Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

    ✓ Peer-reviewed TREM2 and immune genetics Molecular cell

    Key finding: Despite this, the global landscape of intercellular signaling in mammalian liver has not been elucidated. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-08-01

    TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models

    ✓ Peer-reviewed Risk genes beyond APOE FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: However, the potential role of TREM2 effect on synucleinopathy has not been characterized. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-08-01

    Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Science translational medicine

    Key finding: We therefore examined whether soluble TREM2 (sTREM2) concentrations in cerebrospinal fluid (CSF) were associated with reduced rates of cognitive decline and clinical progression in subjects with AD or mild cognitive impairment (MCI). +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-08-01

    The role of zinc, copper, manganese and iron in neurodegenerative diseases

    ✓ Peer-reviewed Lewy body dementia Neurotoxicology

    Key finding: Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2019-08-01

    Neurosyphilis

    ✓ Peer-reviewed Disparities Seminars in neurology

    Key finding: The early stages include asymptomatic meningitis, symptomatic meningitis, gumma, and meningovascular syphilis, while the late stages include dementia paralytica and tabes dorsalis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-08-01

    Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia

    ✓ Peer-reviewed Disparities JAMA

    Key finding: Late-life declines in blood pressure following prolonged hypertension may be associated with poor cognitive outcomes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2019-08-01

    Alzheimer's pathology targets distinct memory networks in the ageing brain

    ✓ Peer-reviewed Caregiving Brain : a journal of neurology

    Key finding: Post-mortem studies indicate that in ageing and Alzheimer's disease tau tangles deposit early in the transentorhinal cortex, a region located in the anterior-temporal lobe that is critical for object memory. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2019-08-01

    White matter hyperintensities: relationship to amyloid and tau burden

    ✓ Peer-reviewed Caregiving Brain : a journal of neurology

    Key finding: The objectives of this study were to investigate the topographic patterns of white matter hyperintensities associated with Alzheimer's disease biomarkers measured using PET. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-08-01

    Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study

    ✓ Peer-reviewed Getting a diagnosis JAMA internal medicine

    Key finding: Exposure to several types of strong anticholinergic drugs is associated with an increased risk of dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-08-01

    Age-Related Hearing Loss

    ✓ Peer-reviewed Prevention and risk Cold Spring Harbor perspectives in medicine

    Key finding: This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2019-08-01

    Association of Lifestyle and Genetic Risk With Incidence of Dementia

    ✓ Peer-reviewed Prevention and risk JAMA

    Key finding: Among older adults without cognitive impairment or dementia, both an unfavorable lifestyle and high genetic risk were significantly associated with higher dementia risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2019-08-01

    The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

    ✓ Peer-reviewed Genetics Science translational medicine

    Key finding: Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-08-01

    Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions

    ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology

    Key finding: Significant regions were entered into a stepwise multiple regression analysis to investigate the independent correlation of each biomarker to baseline regional CMRGlc and its progression in patients with MCI.

    Full summary, score breakdown and related studies → Original source

  15. 2019-08-01

    Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: An antecedent rise in Aβ was associated with subsequent changes in tau (1.07 flortaucipir standardized uptake value ratios [SUVr]/PiB-SUVr; 95% CI, 0.13-3.46; P = .02). +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2019-08-01

    High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Plasma Aβ42/Aβ40, especially when combined with age and APOE ε4 status, accurately diagnoses brain amyloidosis and can be used to screen cognitively normal individuals for brain amyloidosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

July 2019 9

  1. 2019-07-31

    Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults

    ✓ Peer-reviewed Genetics Journal of the American Heart Association

    Key finding: APOE-ε4 carrier status appears to modify the cross-sectional association between cardiac output and neuropsychological performance such that lower cardiac output relates to poorer performances among carriers of the ε4 allele. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-07-31

    Layer-Wise Relevance Propagation for Explaining Deep Neural Network Decisions in MRI-Based Alzheimer's Disease Classification

    ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

    Key finding: Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer's disease (AD) detection based on structural magnetic resonance imaging (MRI) data. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2019-07-31

    Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: Lower Aß-42 levels were associated with a reported decline in memory and language abilities, and with the following SCD-plus features: onset of subjective decline within 5 years, confirmation of cognitive decline by an informant, and decline-related worries. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-07-31

    Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: During a mean follow-up of 12.1 years, 1,520 individuals developed dementia, 1,194 of whom had AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-07-31

    Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

    ✓ Peer-reviewed Genetics Nature reviews. Neurology

    Key finding: Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2019-07-30

    Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

    ✓ Peer-reviewed Inflammation and the immune system The EMBO journal

    Key finding: Neuroinflammation has emerged as an additional pathological component. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-07-30

    Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

    ✓ Peer-reviewed TREM2 and immune genetics Scientific reports

    Key finding: The objective of this study is to engineer brain region-specific organoids from hiPSCs incorporated with isogenic microglia-like cells in order to enhance immune function. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2019-07-29

    A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases

    ✓ Peer-reviewed Risk factors Nephrology Dialysis Transplantation

    Key finding: As a result, kidney disease has been largely overlooked by health authorities and governments in most countries [9]. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2019-07-29

    Added value of amyloid PET in individualized risk predictions for MCI patients

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: The combined model (Harrell's C = 0.82 [0.78-0.86]) was significantly superior to demographics (β = 0.100, P < .001), magnetic resonance imaging (β = 0.037, P = .011), and PET only models (β = 0.053, P = .003).The models can be used to calculate individualized risk, for example, a female MCI patient (age = 60, APOE ε4 positive, Mini-Mental State Examination = 25, hippocampal volume = 5.8 cm3, amyloid PET positive) has 35% (19-57) risk in one year and 85% (64-97) risk in three years. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →