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Alzheimer's disease: risk factors and potentially protective measures
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG.. Journal of biomedical science, 2019-05-09
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills deficiencies, which are often accompanied by behavioral disorders such as apathy, aggressiveness and depression. The presence of extracellular plaques of insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein (P-tau) in the neuronal cytoplasm is a remarkable pathophysiological cause in patients' brains. Approximately 70% of the risk of developing AD can be attributed to genetics. However, acquired factors such as cerebrovascular diseases, diabetes, hypertension, obesity and dyslipidemia increase the risk of AD development. The aim of the present minireview was to summarize the pathophysiological mechanism and the main risk factors for AD. As a complement, some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.
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APA 7th
Silva, M. V. F., Loures, C. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Carvalho, M. D. G. (2019). Alzheimer's disease: risk factors and potentially protective measures. Journal of biomedical science. https://doi.org/10.1186/s12929-019-0524-y
Vancouver
Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG. Alzheimer's disease: risk factors and potentially protective measures. Journal of biomedical science. 2019. doi:10.1186/s12929-019-0524-y. PMID: 31072403.
BibTeX
@article{silva2019-31072403,
author = {Silva, M. V. F. and Loures, C. M. G. and Alves, L. C. V. and de Souza, L. C. and Borges, K. B. G. and Carvalho, M. D. G.},
title = {{Alzheimer's disease: risk factors and potentially protective measures}},
journal = {Journal of biomedical science},
year = {2019},
doi = {10.1186/s12929-019-0524-y},
pmid = {31072403},
url = {https://doi.org/10.1186/s12929-019-0524-y}
}
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Key findings
- As a complement, some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.
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Study details
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of biomedical science) |
| Journal's citation record | 2 / 4 | Journal of Biomedical Science: journal h-index 151 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 940 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 104.4 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 6 / 6 | Cited 47.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 4 / 4 | Cited 477 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author María das Graças Carvalho Ferriani: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidade Federal de Minas Gerais: institution h-index 527 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31072403) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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Read the original
- DOI: 10.1186/s12929-019-0524-y
- PubMed: 31072403
- Original source →
- Free full text: Journal of Biomedical Science →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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