Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,351–15,375 of 27,380 studies, newest first · page 615 of 1096.
February 2017 25
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2017-02-05
Survival after dementia diagnosis in five racial/ethnic groups
57/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Survival after dementia diagnosis differs by race/ethnicity, with shortest survival among whites and longest among Asian Americans. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-05
Factors associated with the quality of life of family carers of people with dementia: A systematic review
69/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The quality and level of evidence supporting each theme varied. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-04
Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease
39/100 ✓ Peer-reviewed Risk factors Progress in molecular biology and translational science
Key finding: Among them, SIRT3 is exclusively present in mitochondria, playing a significant role in metabolic adaptation.
Full summary, score breakdown and related studies → Original source
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2017-02-04
Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology
39/100 ✓ Peer-reviewed Tau biomarkers Journal of psychiatric research
Key finding: Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-03
Alzheimer disease: CSF biomarkers for Alzheimer disease - approaching consensus
39/100 ✓ Peer-reviewed Tau biomarkers Nature reviews. Neurology
Key finding: A European working group has provided a new set of recommendations for the use of cerebrospinal fluid (CSF) biomarkers in the diagnostic evaluation of Alzheimer disease and mild cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-03
Prevalence and determinants of undetected dementia in the community: a systematic literature review and a meta-analysis
68/100 ✓ Peer-reviewed Getting a diagnosis BMJ open
Key finding: The pooled rate of undetected dementia was 61.7% (95% CI 55.0% to 68.0%).
Full summary, score breakdown and related studies → Original source
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2017-02-02
CJD mimics and chameleons
41/100 ✓ Peer-reviewed End-of-life care Practical neurology
Key finding: We have based this pragmatic review on the experiences of a specialist prion referral centre in the UK, which, unsurprisingly, is strongly biased towards seeing patients with CJD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-02
MRI-Based Classification Models in Prediction of Mild Cognitive Impairment and Dementia in Late-Life Depression
49/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in aging neuroscience
Key finding: Late-life depression (LLD) is associated with development of different types of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02 month only
Narrative collisions, sociocultural pressures and dementia: the relational basis of personhood reconsidered
39/100 ✓ Peer-reviewed Caregiving Sociology of health & illness
Key finding: It is concluded that a sociologically-informed perspective can help to reinforce the academic understanding of personhood.
Full summary, score breakdown and related studies → Original source
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2017-02-01
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
39/100 ✓ Peer-reviewed Disease mechanisms Cerebral cortex (New York, N.Y. : 1991)
Key finding: Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02 month only
Association Between Lithium Use and Risk of Alzheimer's Disease
71/100 ✓ Peer-reviewed Drug development The Journal of clinical psychiatry
Key finding: We identified 63,347 cases with Alzheimer's disease and 126,694 controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02 month only
[Amyloid positron-emission-tomography with [18 F]-florbetaben in the diagnostic workup of dementia patients]
46/100 ✓ Peer-reviewed Brain scans and imaging Der Nervenarzt
Key finding: 17 out of 33 patients were scored as FBB-PET positive. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
41/100 ✓ Peer-reviewed Inflammation and the immune system Redox biology
Key finding: To this end, we generated Gpx4BIKO mouse, a mouse model with conditional deletion in forebrain neurons of glutathione peroxidase 4 (Gpx4), a key regulator of ferroptosis, and showed that treatment with tamoxifen led to deletion of Gpx4 primarily in forebrain neurons of adult Gpx4BIKO mice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease
55/100 ✓ Peer-reviewed Drug development JAMA neurology
Key finding: However, several drugs prescribed for other conditions have been associated with reducing its risk. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78)
41/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology
Key finding: Molecular defects in this gene have been causally associated with Kufor-Rakeb syndrome (#606693), an autosomal recessive form of juvenile-onset parkinsonism, and neuronal ceroid lipofuscinosis (#606693), a neurodegenerative disorder characterized by the intracellular accumulation of autofluorescent lipopigments. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
56/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: The findings suggest that detection of αSyn oligomers by αSyn-PMCA in the CSF of patients affected by PD may offer a good opportunity for a sensitive and specific biochemical diagnosis of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Markers of neuroinflammation associated with Alzheimer's disease pathology in older adults
52/100 ✓ Peer-reviewed Biomarkers Brain, behavior, and immunity
Key finding: Studies on markers of inflammation in subjects with mild cognitive impairment or AD dementia provided inconsistent results. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Sex differences in the association between AD biomarkers and cognitive decline
57/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain imaging and behavior
Key finding: Previous autopsy work has suggested that, in the presence of AD neuropathology, females are more susceptible to the clinical manifestation of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
57/100 ✓ Peer-reviewed Inflammation and the immune system Nature medicine
Key finding: Furthermore, α-synuclein contributes to the fibrilization of amyloid-b and tau, two key proteins in Alzheimer's disease, which suggests a central role for α-synuclein toxicity in neurodegeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants
56/100 ✓ Peer-reviewed Long-term cohort studies European heart journal
Key finding: Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease
48/100 ✓ Peer-reviewed TREM2 and immune genetics Current opinion in lipidology
Key finding: APOE4 genotype is the strongest genetic risk factor for Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-01
Epidemiology of Parkinson's disease
50/100 ✓ Peer-reviewed Lewy body dementia Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Several environmental factors are associated with increased risk of PD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-01
Vascular Cognitive Impairment
55/100 ✓ Peer-reviewed Brain scans and imaging Circulation research
Key finding: Vascular cognitive impairment refers to all forms of cognitive disorder associated with cerebrovascular disease, regardless of the specific mechanisms involved. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-01
Natural history of pure autonomic failure: A United States prospective cohort
56/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: Patients presenting with pure autonomic failure are at high risk of phenoconverting to a manifest CNS synucleinopathy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-01
Validation of olfactory deficit as a biomarker of Alzheimer disease
52/100 ✓ Peer-reviewed Genetics Neurology. Clinical practice
Key finding: Olfactory identification deficit is a useful screening tool for AD-related amnestic disorder, with sensitivity and specificity comparable to other established biomarkers, with benefits such as ease of administration and low cost.
Full summary, score breakdown and related studies → Original source
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