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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Down syndrome and Alzheimer's

Topic: Brain proteins, microglia and lab models

We place these findings in the context of the selective, but by no means unique, involvement of BFCNs and their trophic dependence on NGF signaling and speculate as to how pathogenesis in these neurons is initiated, amplified and ultimately results in their dysfunction and death. Finally, we address current attempts to prevent and/or treat AD in light of advances in understanding pathogenetic mechanisms and suggest that studies in the DS population may provide unique insights into AD pathogenesis and treatment.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Chen, X. Q., & Mobley, W. C. (2019). Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Frontiers in neuroscience. https://doi.org/10.3389/fnins.2019.00446

Vancouver

Chen XQ, Mobley WC. Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Frontiers in neuroscience. 2019. doi:10.3389/fnins.2019.00446. PMID: 31133787.

BibTeX

@article{chen2019-31133787,
  author  = {Chen, X. Q. and Mobley, W. C.},
  title   = {{Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.00446},
  pmid    = {31133787},
  url     = {https://doi.org/10.3389/fnins.2019.00446}
}

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Key findings

We place these findings in the context of the selective, but by no means unique, involvement of BFCNs and their trophic dependence on NGF signaling and speculate as to how pathogenesis in these neurons is initiated, amplified and ultimately results in their dysfunction and death.
Finally, we address current attempts to prevent and/or treat AD in light of advances in understanding pathogenetic mechanisms and suggest that studies in the DS population may provide unique insights into AD pathogenesis and treatment.

Why it matters

This review discusses how basal forebrain cholinergic neurons and their dependence on NGF signaling may be involved in Alzheimer pathogenesis, and suggests that studying people with Down syndrome could give useful insights. It addresses current attempts to prevent and treat Alzheimer's disease but reports no new treatment results.

Study details

Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in neuroscience)
Journal's citation record	2 / 4	Frontiers in Neuroscience: journal h-index 226 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 176 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	19.6 citations a year over 9 year(s) since 2019
Impact for its field and year	4 / 6	Cited 14.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	3 / 4	Cited 51 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author William Cary Mobley: h-index 84 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31133787)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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