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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,226–12,250 of 27,380 studies, newest first · page 490 of 1096.

December 2019 25

  1. 2019-12-09

    Elevation of plasma soluble amyloid precursor protein beta in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Archives of gerontology and geriatrics

    Key finding: The plasma level of sAPPβ was significantly increased in AD patients than in cognitively healthy controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-12-09

    Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Consistent with their unique ontology, microglia may express specific physiological markers, which have been partly described in recent years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-12-09

    Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia (New York, N. Y.)

    Key finding: CSF synaptic biomarkers, particularly NPTX2, which regulates synaptic homeostasis, relate to cognition and predict progression in AD beyond Aβ1-42 and Tau. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2019-12-09

    Racial disparities and temporal trends in dementia misdiagnosis risk in the United States

    ✓ Peer-reviewed Disparities Alzheimer's & dementia (New York, N. Y.)

    Key finding: Our results suggest that efforts to reduce racial disparities in underdiagnosis are warranted. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2019-12-09

    Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research

    ✓ Peer-reviewed Biomarkers Biomedicines

    Key finding: The application of amyloid, tau, and neurodegeneration biomarkers, including new biomarkers-such as Tau positron emission tomography, neurofilament light chain (blood and Cerebrospinal fluid (CSF) biomarker of axonal degeneration) and neurogranin (CSF biomarker of synaptic functioning)-to clinical trials allows more precise staging of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-12-08

    Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

    ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

    Key finding: In this review, we discuss how different forms of synaptic plasticity, including homeostatic and anti-homeostatic mechanisms, could be directly involved in generating specific brain network characteristics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-12-06

    The microbiome-gut-brain axis in acute and chronic brain diseases

    ✓ Peer-reviewed Disease mechanisms Current opinion in neurobiology

    Key finding: The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2019-12-06

    Cognitive symptoms of Alzheimer's disease: clinical management and prevention

    ✓ Peer-reviewed Treatments BMJ (Clinical research ed.)

    Key finding: Memantine has a smaller benefit on cognition overall which is limited to the moderate to severe stages, and the combination of a cholinesterase inhibitor and memantine may have additional efficacy.

    Full summary, score breakdown and related studies → Original source

  9. 2019-12-06

    Anticholinergic Drugs in Geriatric Psychopharmacology

    ✓ Peer-reviewed Clinical safety Frontiers in neuroscience

    Key finding: This review presents different aspects of the use of anticholinergics in old age with a focus in psychogeriatric patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-12-06

    Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network

    ✓ Peer-reviewed Long-term cohort studies IEEE transactions on bio-medical engineering

    Key finding: Although several pioneering studies have been devoted to automated AD diagnosis based on resting-state functional magnetic resonance imaging (rs-fMRI), their performance is somewhat limited due to non-effective mining of spatial-temporal dependency. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-12-05

    Education does not protect cognitive function from brain pathology in the ADNI 2 cohort

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: However, few studies have demonstrated that education statistically moderates the effects of pathology on cognition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2019-12-05

    Intrinsic functional connectivity, CSF biomarker profiles and their relation to cognitive function in mild cognitive impairment

    ✓ Peer-reviewed Tau biomarkers Acta neuropsychiatrica

    Key finding: Recent research suggests that, in addition to established biomarkers such as CSF Aß42, total tau and hyperphosphorylated tau, resting state connectivity established by functional magnetic resonance imaging might also be a feasible biomarker for prodromal stages of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2019-12-05

    Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer's disease (AD) relies on dichotomous biomarker cut-off values. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-12-05

    Predicting dementia with routine care EMR data

    ✓ Peer-reviewed Digital health tools Artificial intelligence in medicine

    Key finding: The results show that the combined model is generalizable across multiple institutions and is able to predict dementia within one year of its onset with an accuracy of nearly 80% despite the fact that it was trained using routine care data.

    Full summary, score breakdown and related studies → Original source

  15. 2019-12-04

    Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial

    ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

    Key finding: This pilot study showed that functional tasks exercise using simulated functional tasks as a means of combined cognitive and exercise program is feasible and beneficial in improving the memory and functional status of older adults with mild cognitive impairment as well as reducing the care-related burdens of their caregivers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2019-12-04

    Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Molecular brain

    Key finding: Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2019-12-04

    Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Aging cell

    Key finding: Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in regulating amyloid-beta (Aβ) pathology is still poorly understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-12-04

    Risk factors, costs and complications of delayed hospital discharge from internal medicine wards at a Canadian academic medical centre: retrospective cohort study

    ✓ Peer-reviewed Digital health tools BMC health services research

    Key finding: Delayed discharge is associated with higher hospital costs and complication rates especially nosocomial infections. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2019-12-04

    Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Increased concentrations of baseline plasma t-tau may predict in vivo structural BFCS atrophy progression in older adults at risk for AD, independently of β-amyloid status and APOE genotype. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2019-12-03

    Classification and Visualization of Alzheimer’s Disease using Volumetric Convolutional Neural Network and Transfer Learning

    ✓ Peer-reviewed Brain scans and imaging Scientific Reports

    Key finding: Recently, deep-learning-based approaches have been proposed for the classification of neuroimaging data related to Alzheimer's disease (AD), and significant progress has been made. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2019-12-03

    Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

    ✓ Peer-reviewed Vascular contributions Neuron

    Key finding: Our findings suggest that low-frequency arteriolar oscillations drive drainage of solutes.

    Full summary, score breakdown and related studies → Original source

  22. 2019-12-02

    Racial Disparity in Cerebrospinal Fluid Amyloid and Tau Biomarkers and Associated Cutoffs for Mild Cognitive Impairment

    ✓ Peer-reviewed Biomarkers JAMA network open

    Key finding: Data from 362 study participants were analyzed (mean [SD] age, 65.6 [7.9] years), of whom 152 (42.0%) were African American, 230 (63.5%) were women, and 189 (52.2%) had MCI. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2019-12-02

    Exergaming Executive Functions: An Immersive Virtual Reality-Based Cognitive Training for Adults Aged 50 and Older

    ✓ Peer-reviewed Prevention trials Cyberpsychology, behavior and social networking

    Key finding: Prior research suggests that both exergaming and virtual reality (VR)-based training programs could improve executive functions in older adults. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2019-12-02

    Associations of Regional Brain Structural Differences With Aging, Modifiable Risk Factors for Dementia, and Cognitive Performance

    ✓ Peer-reviewed Long-term cohort studies JAMA network open

    Key finding: Identifying brain regions associated with risk factors for dementia could guide mechanistic understanding of risk factors associated with Alzheimer disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-12-02

    Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

    ✓ Peer-reviewed Tau biomarkers JAMA network open

    Key finding: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →