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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,101–13,125 of 27,380 studies, newest first · page 525 of 1096.

February 2019 25

  1. 2019-02-28

    Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    ✓ Peer-reviewed Risk factors Nature genetics

    Key finding: We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-02-27

    Advance care planning in dementia: recommendations for healthcare professionals

    ✓ Peer-reviewed End-of-life care Palliative care

    Key finding: The process of advance care planning in dementia is far from straightforward; as dementia progresses, the ability to consider future thoughts and actions becomes compromised, thus affecting decision-making abilities. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-02-27

    The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain

    ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

    Key finding: Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including ALS, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2019-02-27

    RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: We present an optogenetic approach to reliably induce TDP-43 proteinopathy under spatiotemporal control. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-02-26

    The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People

    ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

    Key finding: A 2-year lifestyle intervention was able to maintain the daily functioning of the at-risk older population. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-02-26

    Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data

    ✓ Peer-reviewed Lewy body dementia European journal of epidemiology

    Key finding: Further research is required to explore the geographic generalisability of these findings.

    Full summary, score breakdown and related studies → Original source

  7. 2019-02-26

    Lifestyle multidomain intervention, omega-3 supplementation, or both for reducing the risk of developing clinically relevant depressive symptoms in older adults with memory complaints? Secondary analysis from the MAPT trial

    ✓ Peer-reviewed Treatments Experimental gerontology

    Key finding: A study with a more intensive multidomain intervention might bring further insights on this topic. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2019-02-22

    Advance Care Planning and Advance Directives: A Multimedia Education Program in Community-Dwelling Older Adults

    ✓ Peer-reviewed End-of-life care Journal of applied gerontology : the official journal of the Southern Gerontological Society

    Key finding: The study showed that 100% of participants in the intervention group (two community centers, n = 52) selected hospice program care for end-of-life care and signed ADs, whereas those in the control group were less likely to do both (p < .001).

    Full summary, score breakdown and related studies → Original source

  9. 2019-02-22

    A Nanoplasmonic Biosensor for Ultrasensitive Detection of Alzheimer's Disease Biomarker Using a Chaotropic Agent

    ✓ Peer-reviewed Biomarkers ACS sensors

    Key finding: However, with current technology, the accuracy of the blood-plasma-based methods is relatively low compared to the traditional methods because the concentration of AD biomarkers in blood plasma is incredibly low, and diverse interference is present in blood plasma, which hinders precise detection. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2019-02-22

    Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: In this in vivo study, we have demonstrated that microglial activation quantified using [ 11 C]PBR28 PET was associated with higher gray matter volume and higher hippocampal volume in patients with MCI. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-02-21

    Disturbed homocysteine metabolism is associated with cancer

    ✓ Peer-reviewed Down syndrome and Alzheimer's Experimental & molecular medicine

    Key finding: While increased homocysteine levels can cause symptoms such as osteoporosis and eye lens dislocation, high homocysteine levels are most closely associated with cardiovascular complications. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2019-02-21

    Digital biomarkers for Alzheimer's disease: the mobile/ wearable devices opportunity

    ✓ Peer-reviewed Digital health tools NPJ digital medicine

    Key finding: A growing body of evidence indicates that cognitive, behavioral, sensory, and motor changes may precede clinical manifestations of AD by several years.

    Full summary, score breakdown and related studies → Original source

  13. 2019-02-21

    Glial activation and inflammation along the Alzheimer's disease continuum

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-02-21

    Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein

    ✓ Peer-reviewed Tau biomarkers Scientific reports

    Key finding: The aim of this study was to examine previously implicated genetic markers in and near IL1RAP in relation to AD risk, CSF tau and Aβ biomarkers, as well as cognitive decline, in a case (AD)-control study and an age homogenous population-based cohort. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-02-19

    The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

    ✓ Peer-reviewed Genetics The Lancet. Neurology

    Key finding: Emerging evidence suggests that these morphological changes reflect functional alterations that affect disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2019-02-19

    Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in neuroinformatics

    Key finding: In its third phase, the Alzheimer's Disease Neuroimaging Initiative (ADNI3) is collecting data across multiple sites and scanners using different dMRI acquisition protocols, to better understand disease effects. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2019-02-19

    Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

    ✓ Peer-reviewed Digital health tools Scientific reports

    Key finding: In the Alzheimer's disease (AD) continuum, the prodromal state of mild cognitive impairment (MCI) precedes AD dementia and identifying MCI individuals at risk of progression is important for clinical management. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-02-18

    Dynamic DNA Methylation During Aging: A "Prophet" of Age-Related Outcomes

    ✓ Peer-reviewed Genetics Frontiers in genetics

    Key finding: Currently, a growing number of studies have shown that dynamic DNA methylation throughout human lifetime exhibits strong correlation with age and age-related outcomes.

    Full summary, score breakdown and related studies → Original source

  19. 2019-02-18

    Polygenic risk and hazard scores for Alzheimer's disease prediction

    ✓ Peer-reviewed Genetics Annals of clinical and translational neurology

    Key finding: Polygenic Risk Score significantly predicted the risk associated with age at AD onset when SNPs were preselected for association to AD at P ≤ 0.001. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2019-02-18

    Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio

    ✓ Peer-reviewed Biomarkers Biochemical and biophysical research communications

    Key finding: Here, we treated AD model mice with iron-containing water and found that Aβ42 deposition in the brain was significantly inhibited, along with a decrease in iron deposition. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2019-02-18

    The Effectiveness of Vitamin E Treatment in Alzheimer's Disease

    ✓ Peer-reviewed Clinical safety International journal of molecular sciences

    Key finding: In this paper we review the studies with and without positive results in Alzheimer's disease and we discuss the reasons why vitamin E as treatment sometimes has positive results on cognition but at others, it does not.

    Full summary, score breakdown and related studies → Original source

  22. 2019-02-18

    Diabetes and Aging: From Treatment Goals to Pharmacologic Therapy

    ✓ Peer-reviewed Clinical safety Frontiers in endocrinology

    Key finding: Old patients with diabetes have a higher risk of common geriatric syndromes, including frailty, cognitive impairment and dementia, urinary incontinence, traumatic falls and fractures, disability, side effects of polypharmacy, which have an important impact on quality of life and may interfere with anti-diabetic treatment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2019-02-18

    Prevalence of mental disorders in China: a cross-sectional epidemiological study

    ✓ Peer-reviewed How common it is The lancet. Psychiatry

    Key finding: Anxiety disorders were the most common class of disorders both in the 12 months before the interview (weighted prevalence 5·0%, 4·2-5·8) and in lifetime (7·6%, 6·3-8·8). +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2019-02-17

    Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

    ✓ Peer-reviewed Genetics Brain pathology (Zurich, Switzerland)

    Key finding: Data from Genome Wide Association Studies (GWAS) identified a number of gene variants that endow a significant risk of developing AD and several of these encode proteins expressed in microglia and proteins that are implicated in the immune response. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-02-15

    WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis

    ✓ Peer-reviewed Vascular contributions Neurology

    Key finding: Presence and severity of WMH are associated with substantially increased risk of dementia, functional impairment, stroke recurrence, and mortality after ischemic stroke. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →