Newest studies

Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

Key finding: Over a median follow-up of 13 years, 5,304 participants developed dementia. +3 more findings

• Risk Factors
• Prevention
• Lifestyle

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Speech Timing Measures Are Not Interchangeable Across Elicitation Methods in Senior Living Residents

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv (preprint)

Key finding: Twelve senior living residents completed four 60-second tasks: category fluency, two picture descriptions, and a self-generated narrative. +4 more findings

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia?

61/100 ✓ Peer-reviewed Drug development Neurology Genetics

Key finding: Mary Poppins famously asserted that "a spoonful of sugar helps the medicine go down," but this bon mot is likely wrong in almost every way.

• Treatments
• Risk Factors

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Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries

35/100 ✓ Peer-reviewed Drug development Neurology Genetics

Key finding: Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used for type 2 diabetes (T2D) and obesity, have demonstrated pleiotropic effects, including cardiovascular benefits, with mounting evidence also suggesting potential beneficial effects on brain health.

• Risk Factors

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Sleep Health in Adults with Intellectual Disability: Recent Advances and Persistent Evidence Gaps

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Current Treatment Options in Neurology

Key finding: Recent Findings Recent observational data in adults with Down syndrome indicate that obstructive sleep apnoea is associated with adverse cardiometabolic, mortality and Alzheimer disease outcomes. +1 more finding

• Lifestyle
• Digital Tools

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Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Clinical Medicine

Key finding: Seizures are a frequent comorbidity in individuals with Down syndrome and can exert significant negative consequences on cognitive capacity and quality of life.

• Down Syndrome
• Genetics

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Dementia Language Models: a generalizable and controllable representation of cognitive impairment

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment bioRxiv

Key finding: We introduce Dementia Language Models (DeLMs) – generalizable and controllable representations of cognitive impairment through language – alongside an evaluation framework for establishing their validity and clinical grounding. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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DNA Methylation Concordance Between Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Human Brain Tissue in Neurodegenerative Diseases

16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia Preprints.org

Key finding: PCA suggested that the preservation method was a major driver of variation, with PC1 explaining 24.2–48.5% of the variance, while PC2 captured additional variation (6.7–14.3%). +3 more findings

• Other Dementias

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Micro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Transcriptomic analyses revealed activation of senescence-associated secretory phenotype (SASP) pathways. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Review of Alzheimer’s Pathophysiology, Diagnostic Methods, and Multimodal Techniques

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Preprints.org

Key finding: There is a better chance for potential treatments to work in the preliminary stages as no significant neuronal damage has occurred in its initial stages, which is why early detection is critical.

• Diagnosis
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Together, these findings demonstrate that the 5xFAD brain retains modest molecular responsiveness to prolonged voluntary exercise but may be unable to mount a sufficiently robust or coordinated response to produce broad neuroprotective effects. +1 more finding

• Brain Biology
• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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LSD-pipeline: Causal Inference of miRNA Network Effects in Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Several miRNAs with no significant direct association with AD showed significant effects when estimated through their target networks, while others significant in direct analysis were not supported at the network level, underscoring the value of network-level analysis. +1 more finding

• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Reducing Neutrophil Sialic Acid Residues Alleviates Cerebral Hypoperfusion in Alzheimer’s Models

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

Key finding: Elevated terminal sialylation of neutrophil glycoproteins contributes to capillary stalling and cerebral hypoperfusion in AD.

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Aging and Alcohol Withdrawal Escalate CNS Hyperexcitability Across the Lifespan

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk Research Square

Key finding: Aging and alcohol significantly increased CNS hyperexcitability in an age, strain, and sex dependent manner, demonstrating alcohol exacerbates aging related CNS hyperexcitability.

• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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When Insomnia Becomes an Economic Disease: Linking Phenotype, Comorbidity, Treatment, and Societal Cost—An Evidence-Based Narrative Review

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

Key finding: Insomnia disorder affects approximately 10–20% of adults and is usually chronic. +4 more findings

• Policy
• Risk Factors
• Treatments

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Remote Digital Cognitive Assessment in a Trial-Ready Alzheimer’s Cohort: A Scalable Approach for Early Intervention Studies

48/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

Key finding: Despite this, remote measures demonstrated excellent reliability (ICCs > 0.90 after 10 sessions) and strong construct validity, with tasks loading onto memory, attention, and executive function domains. +4 more findings

• Diagnosis
• Clinical Trials

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White Matter Slow-4 fALFF as a Complementary Marker in the Multimodal Alzheimer’s Disease Biomarker Landscape

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: WM fALFF was significantly associated with GFAP (partial RZ = 5.35%), amyloid PET (partial RZ = 2.17%), tau PET (partial RZ = 3.52%), executive function (partial RZ = 2.61%), and mPACC (partial RZ = 3.53%). +3 more findings

• Biomarkers
• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: We found that eCIRP levels were significantly elevated in the cerebrospinal fluid (CSF) and plasma of AD patients compared with age-matched non-AD subjects, as well as in hTau.P301S mice (a model of AD tauopathy) compared with wildtype control mice.

• Biomarkers
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration

45/100 ✓ Peer-reviewed Vascular contributions Cell

Key finding: The strongest genetic AD risk factor, apolipoprotein E4 (APOE4), is associated with cerebrovascular degeneration, including vascular amyloid deposition and fibrosis. +1 more finding

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Study of Ancestry, Health, Environment, and Late-Life Neurodegeneration (SAHEL)

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Planned analyses will integrate gut microbiota profiling, retinal imaging, and brain magnetic resonance imaging to investigate biological pathways and markers associated with healthy aging and cognitive outcomes.

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Elevation in Plasma p-tau217 Concentrations Among Blood Donors: An Exploratory Cross-Sectional Study

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: Plasma p-tau217 concentrations were positively associated with plasma TNF- (Kendalls {tau} = 0.339; P < .001) and IL-6 (Kendalls {tau} = 0.310; P < .001) concentrations. +4 more findings

• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cognition in Cardiovascular Disease

30/100 ✓ Peer-reviewed Treatments Current Neurology and Neuroscience Reports

Key finding: Acute cerebrovascular events once dominated efforts to protect the brain from cardiovascular disease.

• Treatments
• Risk Factors

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Neuroinflamación como diana terapéutica en la enfermedad de Alzheimer: avances clínicos y perspectivas futuras

29/100 ✓ Peer-reviewed Genetics Ciencia Latina Revista Científica Multidisciplinar

Key finding: También se documentó la participación de astrocitos, vías como NF-κB, MAPK, JAK/STAT e inflamasomas, así como interacciones entre neuroinflamación, tau y APOE. +4 more findings

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Parkinson’s Disease Onset in Light of Acquired Irreversible Piezo2 Channelopathy

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Preprints.org

Key finding: Not a single common initiating cause had been attributed to these neurodegenerative diseases due to their multifactorial disease background. +4 more findings

• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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High-Dimensional Multi-Omic Mapping of Post-Mortem Human Brain Using Iterative Indirect Immunofluorescence Imaging on Xenium-Processed Tissues

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv

Key finding: Immunofluorescence staining of FFPE tissue following Xenium processing also preserves cellular morphology, allowing the morphological complexity of distinct cell types to be captured and quantitated, especially for glial cells with highly ramified processes. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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