Newest studies

Impact of PET Reconstruction on Amyloid-β Quantitation in Cross-Sectional and Longitudinal Analyses

61/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: In the cross-sectional study, CLs in both the Aβ- and the Aβ+ groups were impacted by the FWHM of the reconstruction method. +4 more findings

• Brain Scans

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Clinical Practice Guideline: Age-Related Hearing Loss

41/100 ✓ Peer-reviewed Digital health tools Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Key finding: It is associated with various sociodemographic factors and health risks including dementia, depression, cardiovascular disease, and falls. +1 more finding

• Risk Factors

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Neuroinflammation in dementia: A meta-analysis of PET imaging studies

52/100 ✓ Peer-reviewed Inflammation and the immune system Medicine

Key finding: This study summarizes the existing literature on TSPO expression in specific regions of the brain in patients with dementia, and also provides some preliminary evidence on the possible association between neuroinflammation and dementia. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains

57/100 ✓ Peer-reviewed Tau biomarkers Brain : a journal of neurology

Key finding: Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascent Alzheimer's disease (AD) pathology. +3 more findings

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Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial

71/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: This randomized clinical trial demonstrated the positive effects of rTMS on cognitive and functional performance, and the plastic changes in the hippocampal-cortical network. +4 more findings

• Clinical Trials

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Dementia Prevention and Treatment: A Narrative Review

62/100 ✓ Peer-reviewed Treatments JAMA internal medicine

Key finding: Although current prevention and treatment approaches to dementia have been less than optimally successful, substantial investments in dementia research will undoubtedly provide new answers to reducing the burden of dementia worldwide.

• Treatments
• Prevention
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Quantitative Brain Amyloid PET

52/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Yet, there are significant challenges and hurdles to overcome before it can be implemented into widespread clinical practice.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

67/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology

Key finding: Across the brain, people with Down syndrome had greater concentrations of tau for a given level of amyloid compared with people with autosomal-dominant Alzheimer's disease. +2 more findings

• Down Syndrome

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Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death

70/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: Of 92 383 participants, 60 582 (65.6%) were women and the mean (SD) age was 56.4 (8.0) years. +2 more findings

• Risk Factors
• Lifestyle
• Genetics

Full summary, score breakdown and related studies → Original source

APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease

61/100 ✓ Peer-reviewed Genetics Nature Medicine

Key finding: Nearly all APOE4 homozygotes in the postmortem dataset showed Alzheimer's brain pathology from age 55 onward, versus about half of non-carriers +2 more findings

• Genetics

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Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and Aβ42/40 ratio to identify presence of brain amyloid

65/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: 583 participants with suspected Alzheimer's; 53% were amyloid-PET positive +3 more findings

• Biomarkers

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Proteostasis in neurodegenerative diseases

43/100 ✓ Peer-reviewed Disease mechanisms Advances in clinical chemistry

Key finding: The ubiquitin-proteasome system (UPS) and autophagy are major cellular pathways for degrading proteins. +4 more findings

• Brain Biology

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Alzheimer's and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline

68/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Brain volume analyses included 622 participants (mean age ± SD: 70.9 ± 10.2) with an average of 3.3 MRI scans over 4.7 years. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Qualitative Assessment of Food Adulterants for Food Safety in Grocery Store at Avinashi (Tirupur District)

25/100 ✓ Peer-reviewed Risk factors Food Science and Nutrition

Key finding: Food is any substance, composed of carbohydrates, water, fats and proteins, which can be eaten or drunk by animals, including humans, for nutrition or pleasure. +1 more finding

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2024 Alzheimer's disease facts and figures

62/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These figures reflect a decline in the number of caregivers compared with a decade earlier, as well as an increase in the amount of care provided by each remaining caregiver. +1 more finding

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Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease

55/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We found eight flortaucipir covariance patterns which were reproducible and overlapped with relevant gene expression maps. +4 more findings

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Quantification of neurofilament light and glial fibrillary acidic protein in finger-prick blood

46/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: Biomarker concentrations in plasma and finger-prick dried plasma spot samples were significantly positively correlated (neurofilament light ρ = 0.57; GFAP ρ = 0.58, P < 0.001). +2 more findings

• Biomarkers

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Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study

44/100 ✓ Peer-reviewed Brain scans and imaging Neuroradiology

Key finding: 14 out of 16 regional conversions from [18F]Flutemetamol SUVr to Centiloid successfully passed the quality control, showing good reliability and relative variance, especially precuneus/posterior cingulate and prefrontal regions with good stability for Centiloid scaling. +4 more findings

Full summary, score breakdown and related studies → Original source

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We identified sex differences for several classes of metabolites, such as glycerophospholipids, sphingolipids, and amino acids. +4 more findings

• Genetics
• Brain Biology

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α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

54/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: No asymptomatic participant and only 11% (3/27) of the symptomatic patients tested SAA positive. +4 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

The association between neighborhood deprivation and DNA methylation in an autopsy cohort

35/100 ✓ Peer-reviewed Risk factors Aging

Key finding: Previous research has found that living in a disadvantaged neighborhood is associated with poor health outcomes. +4 more findings

• Genetics
• Brain Biology

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Neighborhood Racial and Ethnic Segregation and the Risk of Dementia in Older Adults Living with Kidney Failure

46/100 ✓ Peer-reviewed Risk factors Journal of the American Society of Nephrology

Key finding: Key Points Regardless of race and ethnicity, older adults with kidney failure residing in or receiving care at dialysis facilities located in high-segregation neighborhoods were at a 1.63-fold and 1.53-fold higher risk of dementia diagnosis, respectively. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Epigenetic modifications of DNA and RNA in Alzheimer's disease

43/100 ✓ Peer-reviewed Risk genes beyond APOE Frontiers in molecular neuroscience

Key finding: Investigating the epigenetic mechanisms associated with AD is essential for increasing understanding of pathology and identifying biomarkers for diagnosis and treatment.

• Genetics

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Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: After adjusting for age, health status, and young adult general cognitive ability, plasma NfL level was only significantly associated with processing speed and white matter hyperintensity (WMH) volume, but not with other cognitive or neuroimaging measures. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Dementia Care in Rural Appalachia: Multilevel Analysis of Individual- and County-Level Factors

38/100 ✓ Peer-reviewed Risk factors The Gerontologist

Key finding: Conversely, longer travel times to service providers were linked to use of fewer community-based services (B = -0.21, p < .001). +4 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source