Newest studies

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

55/100 ✓ Peer-reviewed Lewy body dementia Cell

Key finding: Our findings identify a link between stress granule assembly and nucleocytoplasmic transport, two fundamental cellular processes implicated in the pathogenesis of C9ORF72-mediated ALS/FTD and other neurodegenerative diseases.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association

38/100 ✓ Peer-reviewed Prevention trials Circulation

Key finding: Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. +1 more finding

• Prevention
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma phospho‐tau181 increases with Alzheimer's disease clinical severity and is associated with tau‐ and amyloid‐positron emission tomography

54/100 ✓ Peer-reviewed Tau biomarkers Alzheimer s & Dementia

Plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

44/100 ✓ Peer-reviewed TREM2 and immune genetics Biochemical and biophysical research communications

Key finding: Furthermore, microglia could polarize into classic inflammatory M1 and immunosuppressive M2 phenotype. +3 more findings

• Brain Biology
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

The exosome of adipose-derived stem cells reduces β-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer's disease

38/100 ✓ Peer-reviewed Biomarkers Brain research

Key finding: Many studies have suggested that amyloid beta (Aβ) peptides have a pivotal role in AD progression, by mitochondrial dysfunction of neuronal cells. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

41/100 ✓ Peer-reviewed Drug development The Journal of pathology

Key finding: The results illuminate mechanisms of neuroprotection by liraglutide, and indicate that GLP-1 receptor activation may be harnessed to protect brain insulin receptors and synapses in AD. © 2018 The Authors.

• Brain Biology
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Motor and Cognitive Trajectories Before Dementia: Results from Gait and Brain Study

65/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society

Key finding: Prospective cohort study with 5 years of follow-up. +3 more findings

Full summary, score breakdown and related studies → Original source

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

51/100 ✓ Peer-reviewed Getting a diagnosis Cold Spring Harbor perspectives in biology

Key finding: Most clinicians who care for the elderly are not trained to diagnose these conditions, perhaps other than typical Alzheimer's disease (AD). +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Effects of Exercise on Vascular Function, Structure, and Health in Humans

43/100 ✓ Peer-reviewed Prevention and risk Cold Spring Harbor perspectives in medicine

Key finding: The clinical implications of these physiological adaptations are profound. +4 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

45/100 ✓ Peer-reviewed Genetics Nature Genetics

Key finding: Our results demonstrate that our polygenic approach is a powerful way to leverage gene expression data for interpreting GWAS signal.

• Genetics

Full summary, score breakdown and related studies → Original source

Amyloid PET Positivity in Different Primary Progressive Aphasia Phenotypes

46/100 ✓ Peer-reviewed Brain scans and imaging Clinical nuclear medicine

Key finding: Among the 12 patients with PPA syndrome, 8 (66.7%) were considered as amyloid positive. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

An epigenetic biomarker of aging for lifespan and healthspan

41/100 ✓ Peer-reviewed Disease mechanisms Aging

Key finding: Based on an in-depth transcriptional analysis in sorted cells, we find that increased epigenetic, relative to chronological age, is associated with increased activation of pro-inflammatory and interferon pathways, and decreased activation of transcriptional/translational machinery, DNA damage response, and mitochondrial signatures. +1 more finding

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Neuronal Cell Death

38/100 ✓ Peer-reviewed Inflammation and the immune system Physiological reviews

Key finding: However, we now know that there are at least a dozen ways for neurons to die, that blocking a particular mechanism of cell death may not prevent the cell from dying, and that non-neuronal cells also contribute to neuronal death. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

41/100 ✓ Peer-reviewed Treatments Neural regeneration research

Key finding: Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β. +4 more findings

• Treatments
• Prevention
• Diagnosis

Full summary, score breakdown and related studies → Original source

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

52/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: Age-related hippocampal sclerosis may account for a significant proportion of elderly participants with amnestic dementia. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Label-free detection of β-amyloid peptides (Aβ40 and Aβ42): a colorimetric sensor array for plasma monitoring of Alzheimer's disease

38/100 ✓ Peer-reviewed Biomarkers Nanoscale

Key finding: Different aggregation behaviors of nanoparticles through their conjugation with Aβ42 and Aβ40 followed by the coordination of Aβ42 and Aβ40 with Cu(ii) led to diverse spectral and color changes. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Unrecognized Cardiovascular Emergencies Among Medicare Patients

69/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine

Key finding: There were 1 561 940 patients, including 17 963 hospitalized for ruptured AAA, 304 980 for AMI, 1 181 648 for stroke, 19 675 for aortic dissection, and 37 674 for SAH. +2 more findings

• Policy
• Risk Factors

Full summary, score breakdown and related studies → Original source

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

41/100 ✓ Peer-reviewed Disease mechanisms Neural regeneration research

Key finding: A significant contributing factor to the progression of the disease appears to be the progressive accumulation of amyloid-β42 (Aβ42), a small hydrophobic peptide. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

The Impact of Changes in Population Health and Mortality on Future Prevalence of Alzheimer's Disease and Other Dementias in the United States

41/100 ✓ Peer-reviewed Prevention and risk The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Prevention of chronic disease may generate health and longevity benefits but does not reduce burden of dementia. +1 more finding

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cerebral Microbleeds: Imaging and Clinical Significance

54/100 ✓ Peer-reviewed Brain tissue and pathology Radiology

Key finding: CMBs are detected with increasing frequency because of the more widespread use of high magnetic field strength and of newer dedicated MR imaging techniques such as three-dimensional gradient-echo T2*-weighted and SW imaging. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

54/100 ✓ Peer-reviewed Lewy body dementia Cell

Key finding: Our findings reveal two regulatory mechanisms of liquid-phase homeostasis that are disrupted in FUS-associated neurodegeneration.

• Other Dementias

Full summary, score breakdown and related studies → Original source

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

59/100 ✓ Peer-reviewed Lewy body dementia Cell

Key finding: Indeed, significant hypomethylation, which occurs in FUS-associated frontotemporal lobar degeneration (FTLD), induces FUS condensation into stable intermolecular β-sheet-rich hydrogels that disrupt RNP granule function and impair new protein synthesis in neuron terminals. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease

66/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: However, the extent to which increasing age, Aβ, and ε4 are associated with memory decline remains unclear, and the age at which memory decline begins for Aβ-positive ε4 carriers and noncarriers has not been determined. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

64/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD, as well as the multifactorial etiology of dementia.

Full summary, score breakdown and related studies → Original source

Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial

79/100 ✓ Peer-reviewed Prevention and risk JAMA neurology

Key finding: The APOE ε4 carriers and noncarriers were not significantly different at baseline (except for serum cholesterol level). +4 more findings

• Genetics
• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source