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Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study
Liang-Tsai Yeh, Chuan-Yi Tang, Shun-Fa Yang, Han-Wei Yeh, Ying-Tung Yeh, Yu-Hsun Wang, Ming-Chih Chou, Chao-Bin Yeh et al.. International journal of environmental research and public health, 2019-05-09
Topic: Drug trials: efficacy and safety
This study investigated the association of statin use with sepsis risk in patients with dementia. This retrospective cohort study was conducted in Taiwan by using data from the National Health Insurance Research Database. We identified and enrolled 308 patients with newly diagnosed dementia who used statin after dementia diagnosis. These patients were individually propensity score matched (1:1) according to age, sex, hypertension, hyperlipidemia, diabetes, cerebrovascular disease, renal disease, liver disease, asthma, malignancy, parkinsonism, and dementia drugs used (donepezil, rivastigmine, galantamine, and memantine) with 251 controls (statin non-users). A Cox proportional hazard model was used to estimate the adjusted hazard ratio for sepsis in statin users and non-users. After adjustment for other confounding factors, the incidence of sepsis in statin users was 1.42-fold higher than that in non-users (95% confidence interval = 0.81-2.5). In conclusion, our analysis showed no positive association of sepsis with statin use in patients with dementia.
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APA 7th
Yeh, L.-T., Tang, C.-Y., Yang, S.-F., Yeh, H.-W., Yeh, Y.-T., Wang, Y.-H., et al. (2019). Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study. International journal of environmental research and public health. https://doi.org/10.3390/ijerph16091626
Vancouver
Yeh L.-T, Tang C.-Y, Yang S.-F, Yeh H.-W, Yeh Y.-T, Wang Y.-H, et al. Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study. International journal of environmental research and public health. 2019. doi:10.3390/ijerph16091626. PMID: 31075943.
BibTeX
@article{yeh2019-31075943,
author = {Yeh, Liang-Tsai and Tang, Chuan-Yi and Yang, Shun-Fa and Yeh, Han-Wei and Yeh, Ying-Tung and Wang, Yu-Hsun and Chou, Ming-Chih and Yeh, Chao-Bin and others},
title = {{Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study}},
journal = {International journal of environmental research and public health},
year = {2019},
doi = {10.3390/ijerph16091626},
pmid = {31075943},
url = {https://doi.org/10.3390/ijerph16091626}
}
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Key findings
- In conclusion, our analysis showed no positive association of sepsis with statin use in patients with dementia.
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Study details
- Study designcohort study
- Participants308
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of environmental research and public health) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 308 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31075943) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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