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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,826–12,850 of 27,380 studies, newest first · page 514 of 1096.

May 2019 25

  1. 2019-05-22

    An update on genetic frontotemporal dementia

    ✓ Peer-reviewed Prevention and risk Journal of neurology

    Key finding: Grey matter changes on MRI and hypometabolism on FDG-PET are seen at least 10 years before symptom onset with white matter abnormalities seen earlier, but the pattern and exact timing of changes differ between different genetic groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-05-21

    Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

    ✓ Peer-reviewed Genetics Nature Communications

    Key finding: Furthermore, AD neurons have a large cluster of significantly hypomethylated enhancers in the DSCAML1 gene that targets BACE1. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2019-05-21

    APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications

    Key finding: Recent research has identified specific microglial interactions with amyloid plaques that exert important protective functions including attenuation of early pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-05-21

    The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study

    ✓ Peer-reviewed Disparities Diabetes care

    Key finding: Diabetes status, poor glycemic control, and longer diabetes duration were associated with worse cognitive outcomes over a median follow-up of 5 years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-05-20

    Autophagy Dysfunction in Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities

    ✓ Peer-reviewed Disease mechanisms Biological psychiatry

    Key finding: Interestingly, autophagy-activating compounds have also shown some promising results in both clinical trials and preclinical studies.

    Full summary, score breakdown and related studies → Original source

  6. 2019-05-20

    Emerging drugs for progressive supranuclear palsy

    ✓ Peer-reviewed Drug development Expert opinion on emerging drugs

    Key finding: Progressive supranuclear palsy (PSP) is a common cause of atypical parkinsonism and a rapidly progressive disease that greatly burdens both patients and caregivers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-05-20

    The Limitations of Poor Broadband Internet Access for Telemedicine Use in Rural America: An Observational Study

    ✓ Peer-reviewed Risk factors Annals of Internal Medicine

    Full summary, score breakdown and related studies → Original source

  8. 2019-05-20

    A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Digital health

    Key finding: We used records of 2 784 138 patients for the calculation of cumulative incidence and of 3 872 451 patients for the calculation of period prevalence and median age at diagnosis of these conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2019-05-19

    Cohort Profile: The National Health and Aging Trends Study (NHATS)

    ✓ Peer-reviewed Risk factors International Journal of Epidemiology

    Key finding: For self-care and mobility activities, respondents are asked whether in the past month they used specific assistive devices (e.g. grab bar, walker) while doing a particular activity, whether they had difficulty doing the activity by themselves when using named devices, frequencies compared with a year ago and whether they received help. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-05-18

    Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-05-18

    Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Our results encourage an independent validation cohort study to confirm the indication that the plasma Aβ 1-40 /Aβ 1-42 ratio, assessed via Simoa, may improve future standard of care and clinical trial design. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2019-05-17

    Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

    ✓ Peer-reviewed TREM2 and immune genetics Scientific reports

    Key finding: Using a newly developed, highly sensitive reporter cell model, consisting of Jurkat T cells stably overexpressing a reporter gene and a gene encoding TREM2DAP12 fusion protein, we show here that TREM2-dependent signal transduction in response to apoptotic Neuro2a cells is mediated by aminophospholipid ligands, phosphatidylserine and phosphatidylethanolamine, which are not exposed on the intact cell surface, but become exposed upon apoptosis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2019-05-17

    New approaches to studying early brain development in Down syndrome

    ✓ Peer-reviewed Digital health tools Developmental medicine and child neurology

    Key finding: It is a complex condition which results in multiple lifelong health problems, including varying degrees of intellectual disability and delays in speech, memory, and learning.

    Full summary, score breakdown and related studies → Original source

  14. 2019-05-16

    Assessing the Preparedness of the Health Care System Infrastructure in Six European Countries for an Alzheimer's Treatment

    ✓ Peer-reviewed Mild cognitive impairment Rand health quarterly

    Key finding: Based on results from early-stage clinical trials, therapeutic development has focused on the hypothesis that Alzheimer's dementia must be prevented rather than cured, because candidate treatments have not been able to reverse the course of dementia.

    Full summary, score breakdown and related studies → Original source

  15. 2019-05-15

    Brain MRI findings related to Alzheimer's disease in older African American adults

    ✓ Peer-reviewed Disparities Progress in molecular biology and translational science

    Key finding: Unfortunately, while current evidence suggests that African Americans exhibit poorer brain health late in life based on brain MRI measurements, several other aspects of brain MRI markers in this population are unclear, including trajectories of brain MRI markers leading up to old age, relationships between traditional brain health risk factors and brain MRI findings, and the status of brain MRI markers as correlates of cognitive impairment.

    Full summary, score breakdown and related studies → Original source

  16. 2019-05-15

    Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

    ✓ Peer-reviewed Drug development eNeuro

    Key finding: Currently there is no effective therapy available for cognitive impairments in Down syndrome (DS), one of the most prevalent forms of intellectual disability in humans associated with the chromosomes 21 trisomy. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2019-05-15

    Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline

    ✓ Peer-reviewed Digital health tools Nature communications

    Key finding: Networks achieve strong plaque classification on a 10-WSI hold-out set (0.993 and 0.743 areas under the receiver operating characteristic and precision recall curve, respectively). +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-05-14

    Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Against combined Bielschowsky silver staining and immunohistochemistry histopathological scores, statistical parametric mapping had 96% sensitivity, 96% specificity, and 95% accuracy, whereas magnetic resonance-less CapAIBL standardized uptake value ratioWhole Cerebellum had 94% sensitivity, 96% specificity, and 95% accuracy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2019-05-13

    EEG evidence of compensatory mechanisms in preclinical Alzheimer’s disease

    ✓ Peer-reviewed Brain scans and imaging Brain

    Key finding: Neurodegeneration was associated with a widespread increase of median spectral frequency. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2019-05-13

    LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

    ✓ Peer-reviewed Prevention trials Biochemical Society transactions

    Key finding: Mutations in the genes encoding for alpha-synuclein (aSyn), LRRK2, and tau have been associated with familial and sporadic forms of the disease. aSyn is the major component of Lewy bodies and Lewy neurites, which are pathognomonic protein inclusions in PD.

    Full summary, score breakdown and related studies → Original source

  21. 2019-05-13

    C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo

    ✓ Peer-reviewed Disease mechanisms Nature neuroscience

    Key finding: We established an inducible mouse model of poly(GR) toxicity in which (GR) 80 gradually accumulates in cortical excitatory neurons. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2019-05-13

    Small vessel disease: mechanisms and clinical implications

    ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology

    Key finding: Research in humans has identified several manifestations of cerebral microvessel endothelial dysfunction including blood-brain barrier dysfunction, impaired vasodilation, vessel stiffening, dysfunctional blood flow and interstitial fluid drainage, white matter rarefaction, ischaemia, inflammation, myelin damage, and secondary neurodegeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2019-05-12

    NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

    ✓ Peer-reviewed Genetics Biochimica et biophysica acta. Proteins and proteomics

    Key finding: A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.

    Full summary, score breakdown and related studies → Original source

  24. 2019-05-11

    Microglia-mediated neuroinflammation in neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Seminars in cell & developmental biology

    Key finding: However, when there is a neuronal injury or other insult, depending on the type and magnitude of stimuli, microglia will be activated to secrete either proinflammatory factors that enhance cytotoxicity or anti-inflammatory neuroprotective factors that assist in wound healing and tissue repair. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-05-11

    Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

    ✓ Peer-reviewed TREM2 and immune genetics British journal of pharmacology

    Key finding: Recently, the role of microglia in disease, particularly AD, has gained great interest, following the identification of several disease risk-associated genes that are highly expressed in microglia. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →