Newest studies

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

43/100 ✓ Peer-reviewed Disease mechanisms Theranostics

Key finding: PBM treatment significantly improved the typical AD pathologies of memory loss, amyloid plaques, tau hyperphosphorylation, neuronal degeneration, spine damage, and synaptic loss. +4 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

48/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

Key finding: Previous studies have reported less overall neuronal loss, less gliosis, and fewer comorbidities in these individuals. +2 more findings

• Digital Tools
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Verbal Fluency in Metabolic Syndrome

48/100 ✓ Peer-reviewed Risk factors Brain sciences

Key finding: A significant difference in performance was found between the patients and controls, both in the phonetic (p < 0.01) and semantic fluency trials (p < 0.001).

• Risk Factors

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Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: All CSF p-tau biomarkers were accurate predictors of cognitive impairment but CSF p-tau217 demonstrated the largest fold-changes in AD patients in comparison to non-AD dementias and cognitively unimpaired individuals. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage

50/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: CSF NfL is a non-specific marker of aging and white matter integrity with limited sensitivity to specific markers of AD. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial

77/100 ✓ Peer-reviewed Clinical safety Journal of cachexia, sarcopenia and muscle

Key finding: The Vivifrail exercise programme provided significant benefits in functional capacity over usual-care. +2 more findings

• Clinical Trials

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Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment

61/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience

Key finding: The loss of occlusal support may lead to cognitive dysfunction through the reduction of chewing-related stimuli, aggravation of nerve damage, and long-term inflammatory stress.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Assisted Living Residents With Dementia: Being Out in the World and Negotiating Connections

41/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist

Key finding: We identified the centrality of "being out in the world and negotiating connections," which characterizes residents' experiences with the outside world as a process of "working out" engagement with nature, others, and the community. +4 more findings

• Care Services

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The relationship between cognitive engagement and better memory in midlife

55/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Educational attainment and leisure activity engagement were individually associated with memory performance. +4 more findings

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Occupational complexity and cognition in the FINGER multidomain intervention trial

55/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher levels of occupational complexity were associated with better baseline cognition. +4 more findings

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Deep residual inception encoder-decoder network for amyloid PET harmonization

55/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Significantly stronger between-tracer correlations (P < .001) were observed after harmonization for both global amyloid burden indices and voxel-wise measurements in the training cohort and the external testing cohort. +2 more findings

• Brain Scans

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Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging

70/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Lower CSF Aβ42, and higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II ≥ 13), and clinical anxiety (BAI ≥ 10), as well as NPI-Q-assessed anxiety, apathy, and nighttime behavior. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Slowing gait speed precedes cognitive decline by several years

70/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. +3 more findings

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Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Brain amyloidosis differentiated several measures, especially EDTA plasma pTa u 181 A β 42 ( d = 1.29). +3 more findings

• Biomarkers

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Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: retrospective cohort study

67/100 ✓ Peer-reviewed Health systems and care delivery BMJ

Key finding: Among individuals who were diagnosed with SARS-CoV-2, 32% (27 698 of 87 337) sought medical attention in the post-acute period for one or more new or persistent clinical sequelae, which was 11% higher than the 2020 comparison group. +4 more findings

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A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease

55/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer's disease (AD), are largely unknown. +3 more findings

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Software development for quantitative analysis of brain amyloid PET

41/100 ✓ Peer-reviewed Brain scans and imaging Brain and behavior

Key finding: When whole cerebellum or whole cerebellum plus brainstem was chosen as the reference area, an excellent correlation was found between the CL scale calculated by this software and the CL scale published by GAAIN. +3 more findings

• Brain Scans

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Exposure to air pollution and risk of incident dementia in the UK Biobank

56/100 ✓ Peer-reviewed Long-term cohort studies Environmental research

Key finding: Air pollution may cause inflammatory and oxidative stress damage to the brain, leading to neurodegenerative disease. +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Stratification of the Gut Microbiota Composition Landscape across the Alzheimer's Disease Continuum in a Turkish Cohort

48/100 ✓ Peer-reviewed Digital health tools mSystems

Key finding: Our results provide a framework for precision nutrition approaches aiming to modulate the AD gut microbiota. +1 more finding

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Effects of Cognitive Reserve in Alzheimer's Disease and Cognitively Unimpaired Individuals

57/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: The proposed marker was associated with years of education and modulated the effect of pathological burden on cognitive performance in the AD spectrum. +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea

41/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: We found that hearing loss can exacerbate ARHL, damaging sensory-neural cochlear epithelium and causing synaptopathy.

• Risk Factors

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Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

41/100 ✓ Peer-reviewed Drug development European journal of nuclear medicine and molecular imaging

Key finding: PBB5 showed specific binding to recombinant K18 tau fibrils by fluorescence assay, to post-mortem Alzheimer's disease brain tissue homogenate by competitive binding against [11C]PBB3 and to tau deposits (AT-8 positive) in post-mortem corticobasal degeneration and progressive supranuclear palsy brains. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Portable electrochemical micro-workstation platform for simultaneous detection of multiple Alzheimer's disease biomarkers

40/100 ✓ Peer-reviewed Cognitive tests and assessment Mikrochimica acta

Key finding: The integrated electrochemical microarray is mainly used for droplet sample manipulation and signal generation. +4 more findings

• Biomarkers

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Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

43/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

Key finding: Lateral ventricle administration, but not caudal vein injection of BMSC-exos improved AD-like behaviors in the STZ-injected mouse model, as indicated by the increased number of rearing, increased frequency to the central area, and increased duration and distance traveled in the central area in the OFT, and improved preference index of the novel object in the NOR. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The accuracy and robustness of plasma biomarker models for amyloid PET positivity

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Increasing variation greatly impacted the performance of plasma Aβ42/40 in discriminating Aβ status.

• Biomarkers

Full summary, score breakdown and related studies → Original source