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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,951–7,975 of 27,380 studies, newest first · page 319 of 1096.

February 2023 25

  1. 2023-02-13

    Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Brain : a journal of neurology

    Key finding: Our results reveal alternative splicing patterns of PSEN2 specific to sporadic Alzheimer's disease, including a human-specific cryptic exon present in intron 9 of PSEN2 as well as a 77 bp intron retention product before exon 6 that are both significantly elevated in sporadic Alzheimer's disease samples, alongside a significantly lower percentage of canonical full-length PSEN2 transcripts versus familial Alzheimer's disease samples and controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-02-13

    Alzheimer's Disease: An Updated Overview of Its Genetics

    ✓ Peer-reviewed Genetics International journal of molecular sciences

    Key finding: Nonetheless, multiple genes have been associated with the different neuropathological events involved in LOAD, such as the pathological processing of Amyloid beta (Aβ) peptide and Tau protein, as well as synaptic and mitochondrial dysfunctions, neurovascular alterations, oxidative stress, and neuroinflammation, among others. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2023-02-13

    Reporting Down syndrome on the death certificate for Alzheimer disease/unspecified dementia deaths

    ✓ Peer-reviewed Down syndrome and Alzheimer's PloS one

    Key finding: The findings of this study highlight the importance of accurate mortality data for studying and addressing population health trends. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2023-02-12

    Aducanumab for the treatment of Alzheimer's disease: a systematic review

    ✓ Peer-reviewed Treatments Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

    Key finding: Studies reported that aducanumab reduced brain amyloid-beta plaques in a time- and dose-dependent manner (dose-response, P < 0.05) and a slowed decline in cognition (22% reduction) in the high-dose treated group, difference of -0.39 versus placebo in Clinical Dementia Rating Scale Sum Boxes (95% CI, -0.69 to -0.09; P = 0.012) along with a reduced amyloid positron emission tomography standard uptake value ratio score (P < 0.001) and plasma p181-tau (phosphorylated tau) level.

    Full summary, score breakdown and related studies → Original source

  5. 2023-02-11

    Retinal pathological features and proteome signatures of Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Acta neuropathologica

    Key finding: Quantitative examination of superior and inferior temporal retinas from mild cognitive impairment (MCI) and AD patients compared to those with normal cognition (NC) revealed significant increases in amyloid β-protein (Aβ 42 ) forms and novel intraneuronal Aβ oligomers (AβOi), which were closely associated with exacerbated retinal macrogliosis, microgliosis, and tissue atrophy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-02-10

    Air pollution and traffic noise interact to affect cognitive health in older Mexican Americans

    ✓ Peer-reviewed Risk factors Environment international

    Key finding: In total, 104 incident dementia and 159 incident dementia/CIND cases were identified during the 10 years of follow-up. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2023-02-10

    Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: Although poor sleep quality and extreme sleep durations have been associated with brain atrophy and dementia, it is unclear whether sleep disturbances contribute to neural injury in the absence of neurodegeneration and cognitive impairment.

    Full summary, score breakdown and related studies → Original source

  8. 2023-02-10

    Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

    Key finding: Our study indicates that EEG can be used as a useful screening tool for the diagnosis and disease progression evaluation of MCI and AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2023-02-09

    Cardiovascular disease, associated risk factors, and risk of dementia: An umbrella review of meta-analyses

    ✓ Peer-reviewed Risk factors Frontiers in epidemiology

    Key finding: Twenty-five meta-analyses published between 2007 and 2021 were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-02-08

    Aggregation of Disordered Proteins Associated with Neurodegeneration

    ✓ Peer-reviewed Brain tissue and pathology International journal of molecular sciences

    Key finding: Mutations, posttranslational modifications, and truncations are common molecular underpinnings in the formation of aberrant protein conformations that seed aggregation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2023-02-08

    The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer's Disease

    ✓ Peer-reviewed Risk factors Frontiers in neuroendocrinology

    Key finding: Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men.

    Full summary, score breakdown and related studies → Original source

  12. 2023-02-08

    The dynamics of plasma biomarkers across the Alzheimer's continuum

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: This study is the first to delineate the trajectories of plasma biomarkers throughout the Alzheimer's continuum in the Chinese population, providing important implications for future trials targeting plasma GFAP to facilitate AD prevention and treatment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2023-02-08

    Effects of Patient Comorbidities and Demographics on Episode-of-Care Costs Following Total Shoulder Arthroplasty

    ✓ Peer-reviewed Health systems and care delivery The Journal of the American Academy of Orthopaedic Surgeons

    Key finding: Overall, 1,452 shoulder arthroplasty patients were identified (1,402 Medicare and 50 private payer patients). +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-02-08

    Risk of Discharge to Lower-Quality Nursing Homes Among Hospitalized Older Adults With Alzheimer Disease and Related Dementias

    ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

    Key finding: The sample included 2 619 464 patients (mean [SD] age, 81.3 [8.6] years; 61% women; 87% were White; 8% were Black; 22% with ADRD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-02-08

    Classification and staging of Parkinson's disease using video-based eye tracking

    ✓ Peer-reviewed Digital health tools Parkinsonism & related disorders

    Key finding: Biomarkers of saccade, pupil, and blink were extracted from video-based eye tracking to create a classifier with high sensitivity to the landscape of PD cognitive and motor dysfunction. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2023-02-07

    Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation

    ✓ Peer-reviewed Inflammation and the immune system Annual review of immunology

    Key finding: The complement system is an ancient collection of proteolytic cascades with well-described roles in regulation of innate and adaptive immunity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-02-07

    Quantitative comparative analysis of amyloid PET images using three radiopharmaceuticals

    ✓ Peer-reviewed Brain scans and imaging Annals of nuclear medicine

    Key finding: In the negative images of the HS group, the contrast between the white matter and the gray matter was high in the FMM PET images, while striatal uptake was relatively higher in the FPN PET images. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2023-02-07

    Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Our data reveal that ApoE4 is far more disordered and extended than previously thought and retains significant conformational heterogeneity after binding lipids. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-02-07

    Association of serum neurofilament light chain and glial fibrillary acidic protein levels with cognitive decline in Parkinson's disease

    ✓ Peer-reviewed Biomarkers Brain research

    Key finding: We observed significantly higher serum NfL and GFAP levels in PD patients than in HC (p < 0.001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-02-06

    Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond

    ✓ Peer-reviewed Drug development Endocrinology and metabolism (Seoul, Korea)

    Key finding: The evidence-base arising from head-to-head comparative effectiveness studies in people with type 2 diabetes, as well as the recommendations by professional guidelines suggest that GLP1 receptor agonists should replace more traditional treatment options such as sulfonylureas and dipeptidyl-peptidase 4 (DPP4) inhibitors. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2023-02-06

    Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

    ✓ Peer-reviewed Genetics Nature neuroscience

    Key finding: Alzheimer's disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2023-02-06

    Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study

    ✓ Peer-reviewed Prevention trials European journal of neurology

    Key finding: Mediterranean diet adherence is associated with lower increase in pPD probability over time and lower possible/probable pPD and PD/DLB incidence in older Mediterranean people. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2023-02-03

    Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments

    ✓ Peer-reviewed Down syndrome and Alzheimer's Frontiers in neuroscience

    Key finding: This study examines cortical organoids generated from a panel of isogenic trisomic and disomic iPSC lines (subclones) as a model of early fetal brain development in Down syndrome (DS). +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2023-02-03

    Interpretable machine learning for dementia: A systematic review

    ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Future work should incorporate clinicians to validate explanation methods and make conclusive inferences about dementia-related disease pathology.

    Full summary, score breakdown and related studies → Original source

  25. 2023-02-02

    Endothelial Dysfunction in Neurodegenerative Diseases

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Therefore, in the present study, we reviewed the role of vascular dysfunction in aging and neurodegenerative diseases, particularly AD and VaD. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →