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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,326–9,350 of 27,380 studies, newest first · page 374 of 1096.

January 2022 25

  1. 2022-01-12

    Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: The neuropathologic changes underlying Alzheimer disease (AD) start before overt cognitive symptoms arise, but it is not well-known how they relate to the first subtle cognitive changes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-01-12

    Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

    ✓ Peer-reviewed TREM2 and immune genetics The EMBO journal

    Key finding: To understand the contribution of microglial hyperactivation to pathology, we used genetic and pharmacological approaches to suppress TREM2-dependent transition of microglia from a homeostatic to a disease-associated state. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-01-11

    Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

    ✓ Peer-reviewed Disease mechanisms Frontiers in physiology

    Key finding: Lactate is then transferred to neurons where it is used, after conversion to pyruvate, as a rapid energy substrate, and also as a signal that modulates neuronal excitability, homeostasis, and the expression of survival and plasticity genes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-01-11

    Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

    ✓ Peer-reviewed Disease mechanisms Gut

    Key finding: These findings support that a complex gut microbiome is required for behavioural defects, microglia activation and AD pathologies, the gut microbiome contributes to pathologies in an AD mouse model and that dysbiosis of the human microbiome might be a risk factor for AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-01-11

    Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

    ✓ Peer-reviewed TREM2 and immune genetics Communications biology

    Key finding: The underlying mechanisms remain poorly understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-01-10

    CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

    ✓ Peer-reviewed Disease mechanisms IBRO neuroscience reports

    Key finding: In the present study, we demonstrated that inhibition of kinase activity of CaMKII by KN-62 decreases nSOCE amplitude in soma of primary hippocampal neurons. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-01-10

    Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease

    ✓ Peer-reviewed Genetics Alzheimer's research & therapy

    Key finding: Through this approach, we identified 103 ARGs validated by various levels of pathobiological evidence in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2022-01-10

    GLP-1a: Going beyond Traditional Use

    ✓ Peer-reviewed Drug development International journal of molecular sciences

    Key finding: The results showed that GLP-1 agonists can benefit defined off-medication motor scores in Parkinson's Disease and improve emotional well-being.

    Full summary, score breakdown and related studies → Original source

  9. 2022-01-10

    Lewy body disease or diseases with Lewy bodies?

    ✓ Peer-reviewed Disease mechanisms NPJ Parkinson's disease

    Key finding: Molecular-genetic data indicate that not only in PD but also in DLB, a unique genetic architecture can be ascertained, predisposing to the development of specific disease phenotypes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2022-01-09

    The role of inflammasomes in vascular cognitive impairment

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

    Key finding: There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progression. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2022-01-08

    Practical application of Alzheimer's Disease Neuroimaging Initiative plasma P‐tau181 reference data to support diagnosis of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers International Journal of Geriatric Psychiatry

    Key finding: There were significant differences in plasma p‐tau181 values between Controls and those with AD at all ages up to 85 years. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-01-08

    Racial/Ethnic Disparities in Length of Life after Dementia Diagnosis: an 18-Year Follow-up Study of Medicare Beneficiaries

    ✓ Peer-reviewed Disparities Lancet regional health. Americas

    Key finding: Hispanics and Asians diagnosed with dementia had 40% lower mortality risk and African Americans had 13% lower mortality risk than Whites. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-01-07

    Mechanistic insight into the role of metformin in Alzheimer's disease

    ✓ Peer-reviewed Drug development Life sciences

    Key finding: Emerging evidence has revealed the impact of metformin in patients suffering from AD.

    Full summary, score breakdown and related studies → Original source

  14. 2022-01-07

    Serum neurofilament light chain level as a predictor of cognitive stage transition

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: The study shows that higher serum NFL tertile levels correlate with increased risk of cognitive stage transition in both MCI and CU participants. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-01-07

    Plasma MCP-1 and changes on cognitive function in community-dwelling older adults

    ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

    Key finding: Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-01-07

    Benefits and Cost of a $35 Insulin Cost-Sharing Cap for Medicare Patients

    ✓ Peer-reviewed Health systems and care delivery Not indexed

    Key finding: Additionally, it is unknown whether the benefits of this cap would vary between Medicare patients with type 1 versus type 2 diabetes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2022-01-06

    Can exercise training teach us how to treat Alzheimer's disease?

    ✓ Peer-reviewed Prevention trials Ageing research reviews

    Key finding: Physical inactivity is a significant modifiable risk factor for AD, estimated to contribute to 12.7% of AD cases worldwide. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2022-01-06

    Computerized cognitive training in people with depression: a protocol for a systematic review and meta-analysis

    ✓ Peer-reviewed Cognitive tests and assessment Systematic reviews

    Key finding: To the best of our knowledge, this will be the first systematic review and meta-analysis of narrowly defined CCT across clinical populations with depression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2022-01-06

    Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

    ✓ Peer-reviewed Digital health tools Nature biomedical engineering

    Key finding: Our findings suggest the existence of a conserved mechanism of memory loss across the AD models, this mechanism being mediated by defective mitophagy.

    Full summary, score breakdown and related studies → Original source

  20. 2022-01-06

    Vision impairment and cognitive decline among older adults: a systematic review

    ✓ Peer-reviewed Risk factors BMJ open

    Key finding: Our systematic review indicates that a majority of studies examining the vision-cognition relationship report that VI is associated with more cognitive decline, cognitive impairment or dementia among older adults. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2022-01-06

    The Impact of Systemic Inflammation on Alzheimer's Disease Pathology

    ✓ Peer-reviewed Treatments Frontiers in immunology

    Key finding: In order to be able to design more rational and effective treatments, our understanding of the mechanisms behind the pathogenesis and progression of AD urgently needs to be improved. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2022-01-06

    Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

    ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

    Key finding: Further, individuals with a high likelihood of AD showed significantly higher p-tau217 area fraction in 4 different brain areas (entorhinal cortex, inferior temporal gyrus, and superior frontal gyrus) compared to those with Primary age related tauopathy or other non-AD tauopathies. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-01-06

    Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Neuron

    Key finding: We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE study and in a validation cohort of the F.ACE Alzheimer Center Barcelona. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-01-06

    A Systematic Review of Smartphone and Tablet Use by Older Adults With and Without Cognitive Impairment

    ✓ Peer-reviewed Digital health tools Innovation in aging

    Key finding: There was some evidence that the use of smartphones and tablets could aid cognitive function in older adults without cognitive impairment, particularly executive function and processing speed.

    Full summary, score breakdown and related studies → Original source

  25. 2022-01-06

    Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

    ✓ Peer-reviewed Caregiving The Lancet. Public health

    Key finding: Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →