Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,701–21,725 of 27,380 studies, newest first · page 869 of 1096.
January 2009 23
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2009-01-01
Microglial activation and amyloid deposition in mild cognitive impairment: a PET study
53/100 ✓ Peer-reviewed Inflammation and the immune system Neurology
Key finding: Activated microglia may play a role in the pathogenesis of Alzheimer disease (AD) as they cluster around beta-amyloid (Abeta) plaques. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Oxysterols as markers of neurological disease--a review
35/100 ✓ Peer-reviewed Tau biomarkers Scandinavian journal of clinical and laboratory investigation
Key finding: To maintain homeostasis, the excess of cholesterol is converted into the more hydrophilic oxysterol 24S-hydroxycholesterol by the neuron-specific enzyme CYP46A1. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo
46/100 ✓ Peer-reviewed Mild cognitive impairment Behavioural neurology
Key finding: PIB binds specifically to fibrillar beta-amyloid (Abeta) deposits, and is a sensitive marker for Abeta pathology in cognitively normal older individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
47/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology
Key finding: These findings suggest that either microglial activation is limited to later stages of severe AD or [11C](R)-PK11195 is too insensitive to detect the level of microglial activation associated with mild to moderate AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Neuroanatomy and pathology of sporadic Parkinson's disease
41/100 ✓ Peer-reviewed Risk factors Advances in anatomy, embryology, and cell biology
Key finding: The alpha-synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric nervous systems.
Full summary, score breakdown and related studies → Original source
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2009-01-01
The neuropathology of older persons with and without dementia from community versus clinic cohorts
55/100 ✓ Peer-reviewed How common it is Journal of Alzheimer's disease : JAD
Key finding: Community-based persons with clinical AD had less severe AD pathology (p<0.001) and had more cerebral infarcts (p<0.001) compared to clinic-based persons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Postoperative delirium in the elderly: risk factors and outcomes
53/100 ✓ Peer-reviewed How common it is Annals of surgery
Key finding: During the study period, 144 patients were enrolled before major abdominal (40%), thoracic (53%), or vascular (7%) operations. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
The impact of cognitive impairment on rehabilitation outcomes in elderly patients admitted with a femoral neck fracture: a systematic review
53/100 ✓ Peer-reviewed Disparities Journal of geriatric physical therapy (2001)
Key finding: Eleven studies met the inclusion criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Use of antipsychotics among elderly nursing home residents with dementia in the US: an analysis of National Survey Data
39/100 ✓ Peer-reviewed Disparities Drugs & aging
Key finding: However, recent data suggest that the risk of adverse effects may offset the benefits of atypical agents in patients with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Improving access to dementia care: development and evaluation of a rural and remote memory clinic
41/100 ✓ Peer-reviewed Disparities Aging & mental health
Key finding: The availability, accessibility and acceptability of services are critical factors in rural health service delivery. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Family caregivers of people with dementia
48/100 ✓ Peer-reviewed Caregiving Dialogues in clinical neuroscience
Key finding: Psychosocial interventions have been demonstrated to reduce caregiver burden and depression and delay nursing home admission.
Full summary, score breakdown and related studies → Original source
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2009-01-01
Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter?
54/100 ✓ Peer-reviewed Brain scans and imaging Dialogues in clinical neuroscience
Key finding: A significant proportion of older adults experience precipitous cognitive decline that negatively impacts functional activities. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Bone density and brain atrophy in early Alzheimer's disease
45/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Mean BMD was lower in the early AD group (1.11 +/- 0.13) compared to the non-demented control group (1.16 +/- 0.12, p = 0.02), independent of age, gender, habitual physical activity, smoking, depression, estrogen replacement, and apolipoprotein E4 carrier status. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Factors associated with resistance to dementia despite high Alzheimer disease pathology
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Larger brain and hippocampal volumes were associated with preserved cognitive function during life despite a high burden of Alzheimer disease (AD) pathologic lesions at death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited
55/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD
Key finding: Persons with dementia cost the Medicare program (in 2003) $7,135 more than controls (P < 0.001) when using claims to identify dementia, compared to $5,684 more when using ADAMS (P < 0.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
50/100 ✓ Peer-reviewed Getting a diagnosis Journal of neuropathology and experimental neurology
Key finding: Neither the clinical nor the pathological aspects of AD evolve in a linear manner, but thepredictable sequence of AD pathology allows for stage-based correlations with cognitive deterioration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
The treatment of hyperhomocysteinemia
49/100 ✓ Peer-reviewed Prevention and risk Annual review of medicine
Key finding: Although combined folic acid and B-vitamin therapy substantially reduces homocysteine levels, results from randomized placebo-controlled clinical trials testing the effect of vitamin therapy on outcome in these diseases have generally fallen short of expectations. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-01-01
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
54/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD
Key finding: Coffee drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E epsilon4 allele and depressive symptoms. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Vascular risk factors and dementia: how to move forward?
57/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD).
Full summary, score breakdown and related studies → Original source
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2009-01-01
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
53/100 ✓ Peer-reviewed Prevention and risk Dialogues in clinical neuroscience
Key finding: More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial
66/100 ✓ Peer-reviewed Treatments Neurology
Key finding: This double-blind randomized controlled trial of vitamin therapy demonstrates a strong correlation between serum tHcy and plasma Abeta40 concentrations in subjects with ischemic stroke. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-01-01
Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature
60/100 ✓ Peer-reviewed Genetics Alzheimer disease and associated disorders
Key finding: In this review, the evidence that single clinically defined cardiovascular risk factors are significantly associated with incident AD is inconsistent at best. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-01-01
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
49/100 ✓ Peer-reviewed Genetics American journal of human genetics
Key finding: Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect. +1 more finding
Full summary, score breakdown and related studies → Original source
December 2008 2
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2008-12-31
Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics
45/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of disease
Key finding: Using [11C]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-12-30
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation
62/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: We show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases. +2 more findings
Full summary, score breakdown and related studies → Original source
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