Newest studies

Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins

43/100 ✓ Peer-reviewed Disease mechanisms Science advances

Key finding: These findings substantiate a "20S pathway" of proteostasis that directly alleviates protein aggregation and oxidative stress, offering a promising therapeutic angle for neurodegenerative diseases.

• Brain Biology

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Anti-amyloid monoclonal antibody therapies in Alzheimer's disease - a scoping review

41/100 ✓ Peer-reviewed Treatments Neuroscience

Key finding: Across the sample, reductions in amyloid burden were frequently reported (10 trials), with a smaller subset of studies reporting significant cognitive and functional improvements (4 trials), primarily lecanemab and aducanumab in addition to one pooled analysis of solanezumab.

• Treatments

Full summary, score breakdown and related studies → Original source

Previous parity differentially influences cognition in later life depending on dementia status

40/100 ✓ Peer-reviewed Brain tissue and pathology npj Dementia

Key finding: Among females with dementia, higher parity was associated with reduced episodic memory but enhanced executive function performance, whereas a greater son-to-daughter ratio was associated with reduced executive function performance. +1 more finding

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Safety and effectiveness of lecanemab in Chinese patients with early Alzheimer’s disease: Evidence from a multidimensional real-world study

45/100 ✓ Peer-reviewed Cognitive tests and assessment Chinese Medical Journal

Key finding: A total of 64 patients were enrolled in this ongoing real-world study. +4 more findings

• Side Effects
• Treatments

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Associations of cholinergic white matter hyperintensity volume with cognitive decline and incident dementia in older adults: a cohort study

49/100 ✓ Peer-reviewed Cognitive tests and assessment BMC Geriatrics

Key finding: During follow-up, cholinergic WMHV was associated with an annual decline of Mini-Mental State Examination (MMSE) (β coefficient, -0.239; P = 0.004), and incident dementia (HR = 3.54; 95%CI: 2.05-6.10). +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Supporting informal caregivers of dementia patients in China: action needed

37/100 ✓ Peer-reviewed Caregiving Frontiers in Psychology

Key finding: Beyond these practical challenges, caregivers often endure significant physical exhaustion and sleep deprivation from the unrelenting demands of caregiving, which can lead to chronic fatigue and deteriorating health (Liu et al., 2022; Mao et al., 2024). +4 more findings

• Caregiving

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Problem-solving training to improve caregiver burden and depressive symptoms among dementia caregivers: personal and clinical factors of responders vs. non-responders

43/100 ✓ Peer-reviewed Caregiving Frontiers in Public Health

Key finding: We previously demonstrated that PST/DSJ improved caregiver burden and depressive symptoms among caregivers of adults with Alzheimer’s Disease and related dementias (ADRD), regardless of the number of sessions or boosters received. +4 more findings

• Caregiving

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Nursing Interventions in Palliative Care for Advanced Dementia: A Systematic Review of Symptom, Relief, Comfort, and Caregiver Support

75/100 ✓ Peer-reviewed End-of-life care Journal of multidisciplinary healthcare

Key finding: Twenty-three studies from 12 countries were included (8 cluster RCTs, 9 individual RCTs, 6 non-randomized trials). +4 more findings

• End-of-Life Care
• Caregiving

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Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration

43/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration

Key finding: Recent advancements in single-cell sequencing and genome-wide analyses have revealed higher mutation burdens in neurons, particularly in AD-related genes such as Presenilin 1 (PSEN1), Presenilin 2 (PSEN2) and amyloid precursor protein (APP).

• Genetics
• Brain Biology

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Genome-wide association study provides insights into the genetic basis of Lewy body dementia

75/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: We further integrated LBD GWAS with multi-omics datasets, and identified 85 LBD risk genes that were enriched in eight functional clusters including 51 statistically significant pathways (e.g., SYT16 was enriched in the phospholipid binding pathway). +4 more findings

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Machine learning-based estimation of the mild cognitive impairment stage using multimodal physical and behavioral measures

50/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific reports

Key finding: We evaluated the classification performance across various models, including support vector machines, random forest, multilayer perceptron, and convolutional neural network, using unimodal and multimodal datasets. +4 more findings

• Diagnosis
• Early Stage
• Digital Tools

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Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study

41/100 ✓ Peer-reviewed Vascular contributions The British Journal of Psychiatry

Key finding: In the overall cohort (28 403 risperidone users and 136 324 mtatched controls), risperidone was associated with increased risk of stroke (adjusted hazard ratio: 1.28; 95% CI: 1.20-1.37). +4 more findings

• Risk Factors

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Primary age-related tauopathy

50/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica

Key finding: Primary age-related tauopathy (PART) was proposed in 2014 as a neuropathological term to describe patients with Alzheimer's-type medial temporal lobe neurofibrillary degeneration in the absence of significant β-amyloid pathology.

• Brain Biology

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Silodosin as a Novel Inhibitor of Acetylcholinesterase, Butyrylcholinesterase, and BETA-Secretase 1: In Vitro and In Silico Studies

37/100 ✓ Peer-reviewed Risk genes beyond APOE ACS Omega

Key finding: Previous studies have shown that silodosin has the structural requirements for the inhibition of those three enzymes (AChE, BuChE, and BACE-1), which suggests that it can be useful as a multitarget candidate to treat Alzheimer patients. +4 more findings

• Brain Biology

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Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review

41/100 ✓ Peer-reviewed Risk factors Journal of Clinical Medicine

Key finding: Dementia is defined as a substantial decline in cognitive function, and it is inherently associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, and vascular dementia.

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Disparities in Access to Deep Brain Stimulation

39/100 ✓ Peer-reviewed Disparities Stereotactic and Functional Neurosurgery

Key finding: Deep brain stimulation (DBS) is a well-established treatment for several neurological and neuropsychiatric conditions, including movement disorders such as Parkinson's disease, essential tremor, and dystonia, as well as Gilles de la Tourette's syndrome, epilepsy, and obsessive-compulsive disorder.

• Health Equity

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Hypoglycemia as a risk factor for dementia in diabetes: A systematic review

46/100 ✓ Peer-reviewed Getting a diagnosis Advanced Neurology

Key finding: Diabetes is a global health concern associated with complications such as cognitive decline and dementia. +3 more findings

• Risk Factors

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Large Language Models: A Paradigm Shift for Dementia Diagnosis and Care

37/100 ✓ Peer-reviewed Getting a diagnosis British Journal of Hospital Medicine

Key finding: Whilst research into their applications is in its infancy, LLMs can harness vast datasets and powerful algorithms, with significant potential to enhance diagnostic accuracy in dementia, monitor symptom progression, and provide personalised care recommendations.

• Diagnosis

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Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases

47/100 ✓ Peer-reviewed Prevention and risk JACC Advances

Key finding: A total of 9,656 (13.5%) participants had at least 1 CMD at baseline. +4 more findings

• Lifestyle
• Risk Factors

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Transkript zur Episode „Lecanemab“

26/100 ✓ Peer-reviewed Treatments EvidenzUpdate

Key finding: Sind sie die Gamechanger oder vielleicht doch nur Hype? +4 more findings

• Treatments

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Leaving no one behind: findings from stakeholder discussions in Maryland on supporting persons living alone with dementia

26/100 ✓ Peer-reviewed Risk factors Planning Practice and Research

Key finding: Individuals living alone with dementia are rising rapidly, yet this group remains largely unrecognized in dementia care planning. +4 more findings

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Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells

43/100 ✓ Peer-reviewed Inflammation and the immune system Scientific reports

Key finding: Probenecid (Prob), a sulfonamide derivative, has demonstrated neuroprotective and anti-inflammatory properties. +2 more findings

• Brain Biology

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Life-Course Burden of Blood Pressure Is Associated With Midlife Cognitive Function

68/100 ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)

Key finding: Trajectories of systolic BP were separated markedly around 25 to 45 years of age, with the group below the median of cognition score having higher levels of systolic BP than the group above the median. +4 more findings

• Risk Factors

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HSV-1 as a Potential Driver of Alzheimer’s Disease

36/100 ✓ Peer-reviewed Disease mechanisms Pathogens

Key finding: As life expectancy continues to increase worldwide, HSV-1 should remain a focus to minimize its associated health complications within the aging population. +4 more findings

• Brain Biology

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Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv : the preprint server for health sciences

Key finding: The cross-ancestry Bayesian PRS model demonstrated the highest predictive performance in non-European populations. +2 more findings

• Genetics

Scored 25 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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