Newest studies

Impact of APOE genotype on prion-type propagation of tauopathy

41/100 ✓ Peer-reviewed Genetics Acta neuropathologica communications

Key finding: Compared to the parental PS19 mice with mouse Apoe alleles, PS19 mice expressing human APOE alleles generally responded to K18-tau seeding with more intense AT8 immunoreactive phosphorylated tau athology. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

57/100 ✓ Peer-reviewed Biomarkers Cell reports. Medicine

Key finding: Blood neurofilament light (NfL) shows promise as a biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study

45/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: An interquartile range increase in 20-year PM2.5 was associated with a 20% higher risk of dementia (95% confidence interval [CI]: 5%, 37%) and an increased risk of mixed VaD/AD but not AD alone. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease

48/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: Regression analyses were run within cohorts to identify variables associated with retrosplenial or inferior parietal FDG standard uptake value ratios. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Exploration of salient risk factors involved in mild cognitive impairment

41/100 ✓ Peer-reviewed Tau biomarkers The European journal of neuroscience

Key finding: Although MCI affects individuals differently, there are specific indicators of risk commonly associated with the development of MCI. +2 more findings

• Early Stage
• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood-Based Biomarkers for Alzheimer's Disease Diagnosis and Progression: An Overview

43/100 ✓ Peer-reviewed Biomarkers Cells

Key finding: Fluid biomarker discovery for AD is a rapidly expanding field of research aimed at anticipating disease diagnosis and following disease progression over time. +4 more findings

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Quantification of amyloid beta and tau PET without a structural MRI

71/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The best-performing MRI-free approaches had high continuous and dichotomous agreement with MRI-dependent SUVRs for Aβ PET and temporal flortaucipir (R2 ≥0.95; ± agreement ≥92%) and for Alzheimer's disease-related effect sizes; agreement was slightly lower for entorhinal flortaucipir and longitudinal slopes. +1 more finding

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

A Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment: Instrument Validation Study

50/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR aging

Key finding: BrainCheck was able to distinguish between diagnoses of dementia, MCI, and NC, providing a potentially reliable tool for early detection of cognitive impairment.

• Diagnosis
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Effects of Changes in Multiple Chronic Conditions on Medical Costs among Older Adults in South Korea

42/100 ✓ Peer-reviewed Health systems and care delivery Healthcare

Key finding: Out-of-pocket cost was significantly higher among older adults with multiple chronic conditions (p < 0.0001). +2 more findings

• Policy

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Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke

55/100 ✓ Peer-reviewed Inflammation and the immune system Circulation research

Key finding: Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. +3 more findings

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Health status and risk profiles for brain aging of rural-dwelling older adults: Data from the interdisciplinary baseline assessments in MIND-China

64/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (New York, N. Y.)

Key finding: The mean age was 70.9 years (standard deviation, 5.9), 57.2% were women, 40.6% were illiterate, and 88.3% were farmers. +1 more finding

• Health Equity
• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Post-Stroke Cognitive Impairment and Dementia

61/100 ✓ Peer-reviewed Prevention and risk Circulation research

Key finding: Understanding the complex interaction between an acute stroke event and preexisting brain pathology remains a priority and will be critical for developing strategies for personalized prediction, prevention, targeted interventions, and rehabilitation. +4 more findings

Full summary, score breakdown and related studies → Original source

Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline

55/100 ✓ Peer-reviewed Brain scans and imaging Scientific reports

Key finding: Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD). +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

45/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. +3 more findings

• Genetics
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica communications

Key finding: Many of these proteins were more significantly enriched in amyloid plaques than Aβ. +3 more findings

• Brain Biology
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study

66/100 ✓ Peer-reviewed Prevention trials BMJ (Clinical research ed.)

Key finding: A healthy lifestyle was associated with a longer life expectancy among men and women, and they lived a larger proportion of their remaining years without Alzheimer's dementia. +1 more finding

• Lifestyle

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Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults

57/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Blood pressure variability is an emerging risk factor for cognitive decline and dementia, but mechanisms remain unclear. +3 more findings

• Biomarkers
• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

47/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cardiovascular medicine

Key finding: This review aims to summarize the novel insights into the origins, consequences, and molecular mechanisms of foam cells in atherosclerotic plaques. +3 more findings

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Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab

43/100 ✓ Peer-reviewed Treatments Frontiers in aging neuroscience

Key finding: Later, all efforts for AD treatments with targeting the pathogenic factors were unsuccessful over the past decades, which suggested that the pathogenesis of AD is complex. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

47/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: Inhibition of microglial NF-κB in aged PS19 mice rescued tau-mediated learning and memory deficits, restored overall transcriptomic changes while increasing neuronal tau inclusions. +1 more finding

• Brain Biology
• Side Effects

Full summary, score breakdown and related studies → Original source

Current trends in blood biomarker detection and imaging for Alzheimer's disease

40/100 ✓ Peer-reviewed Biomarkers Biosensors & bioelectronics

Key finding: Blood tests are less invasive, more accessible than lumbar puncture for cerebrospinal fluid collection, and are an ideal source of biomarkers. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology

Key finding: The data indicate that synaptic alterations belong to the earliest AD-associated events in DS and highlight the value of serum beta-synuclein as a potential early marker of AD.

• Down Syndrome
• Biomarkers

Full summary, score breakdown and related studies → Original source

Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

57/100 ✓ Peer-reviewed Disparities Environment international

Key finding: Long-term exposure to PM 2.5 , NO 2 , and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment

41/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

Key finding: The pathogenic variant, PSEN1 p.G417S, has been reported to be associated with spastic paraparesis and cotton wool plaques in Japan. +1 more finding

• Genetics
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis

74/100 ✓ Peer-reviewed Clinical safety Journal of translational medicine

Key finding: The results of the present systematic review and meta-analysis revealed that the prevalence of OD is high in different populations and its trend has been increasing in recent years. +4 more findings

Full summary, score breakdown and related studies → Original source