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Slowing gait speed precedes cognitive decline by several years
Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Johan Skoog, Lina Rydén, Hanna Wetterberg, Xinxin Guo, Simona Sacuiu et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022-02-09
Topic: Brain imaging, connectivity and assessment
Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ1- 42 concentrations at the 2009 visit had lost more gait speed compared to previous examinations. Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.
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APA 7th
Skillbäck, T., Blennow, K., Zetterberg, H., Skoog, J., Rydén, L., Wetterberg, H., et al. (2022). Slowing gait speed precedes cognitive decline by several years. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12537
Vancouver
Skillbäck T, Blennow K, Zetterberg H, Skoog J, Rydén L, Wetterberg H, et al. Slowing gait speed precedes cognitive decline by several years. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12537. PMID: 35142034.
BibTeX
@article{skillback2022-35142034,
author = {Skillbäck, Tobias and Blennow, Kaj and Zetterberg, Henrik and Skoog, Johan and Rydén, Lina and Wetterberg, Hanna and Guo, Xinxin and Sacuiu, Simona and others},
title = {{Slowing gait speed precedes cognitive decline by several years}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12537},
pmid = {35142034},
url = {https://doi.org/10.1002/alz.12537}
}
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Key findings
- Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations.
- Baseline gait speed could significantly predict CDR change from baseline to follow-up.
- Subjects with pathological CSF Aβ1- 42 concentrations at the 2009 visit had lost more gait speed compared to previous examinations.
- Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.
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Study details
- Study designcohort study
- Participants287
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 287 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35142034) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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