Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 9,451–9,475 of 27,380 studies, newest first · page 379 of 1096.
January 2022 18
-
2022-01-01
Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts
60/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer's disease : JAD
Key finding: Poor social health is likely associated with cognitive decline and risk of dementia; however, studies show inconsistent results. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Etiology, risk factors, treatments and current status of Alzheimer's disease in Mexico
27/100 ✓ Peer-reviewed Drug development Gaceta medica de Mexico
Key finding: As regards diagnosis, advances in molecule detection techniques at femtomolar scales have allowed to distinguish between healthy and diseased subjects at relatively early stages, although there is still much to be done. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Making the Case for the Accelerated Withdrawal of Aducanumab
39/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD
Key finding: Aducanumab has not demonstrated benefit to patients, failed to meet regulatory guidelines, and is likely to cause both individual and societal harm.
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Limited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer Disease
43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders
Key finding: However, longitudinal change in self-reported spatial navigation ability in preclinical AD has yet to be examined. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies
66/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: Alzheimer disease comorbid pathologic characteristics are common and are associated with more rapid cognitive decline in patients with dementia with Lewy bodies (DLB); therefore, it is anticipated that plasma p-tau concentrations may have utility in assessing cognitive impairment in individuals with this disorder. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial
68/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Analysis was performed on 115 participants as the full analysis set (probiotic 55, placebo 60). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain
53/100 ✓ Peer-reviewed Mild cognitive impairment Journal of extracellular vesicles
Key finding: A protein module enriched in astrocyte-specific EV markers was most significantly associated with the AD pathology and cognitive impairment, suggesting an important role in AD progression. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future
43/100 ✓ Peer-reviewed Digital health tools Journal of neuropathology and experimental neurology
Key finding: Such advancements include improving microscopy and staining techniques, refining diagnostic criteria for the disease, and increased appreciation for disease heterogeneity both in neuroanatomic location of abnormalities as well as overlap with other brain diseases; for example, Lewy body disease and vascular dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood
42/100 ✓ Peer-reviewed Digital health tools Journal of integrative neuroscience
Key finding: Emerging evidence suggests that some of these effects are similar to those seen in adults with symptoms of mild cognitive impairment (MCI) in the early stages of dementia, including impaired concentration, orientation, acquisition of recent memories (anterograde amnesia), recall of past memories (retrograde amnesia), social functioning, and self-care. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Culture, Ethnicity, and Level of Education in Alzheimer's Disease
48/100 ✓ Peer-reviewed Disparities Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Key finding: Studies have found significant effects of culture, preferred language, country of origin, race, and ethnicity on cognitive test performance, although the definition of those grouping terms varies across studies. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Omega-3 Supplementation for the Prevention of Cognitive Decline in Older Adults: Does It Depend on Homocysteine Levels?
61/100 ✓ Peer-reviewed Treatments The journal of nutrition, health & aging
Key finding: This study shows that Hcy levels could modify the association between red blood cell n-3 PUFA and executive function. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2022-01-01
The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy - A Pooled Analysis of Two Randomized Controlled Trials
44/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: Cardiovascular risk factors and lifestyle factors are associated with an increased risk of cognitive decline and dementia in observational studies, and have been targeted by multidomain interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population
55/100 ✓ Peer-reviewed Treatments JAMA cardiology
Key finding: Of 102 607 individuals in the study, 56 559 (55%) were women (median age, 58 years [IQR, 47-67 years]). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease
83/100 ✓ Peer-reviewed Treatments JAMA neurology
Key finding: Of 3285 included participants, the mean (SD) age was 70.4 (7.45) years; 1706 participants (52%) were female, 2661 (81%) had mild cognitive impairment due to Alzheimer disease, and 1777 (54%) used symptomatic medications for Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Amyloid PET: A Questionable Single Primary Surrogate Efficacy Measure on Alzheimer Immunotherapy Trials
44/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: In vivo evidence indicates that PET quantification of amyloid deposition is distorted and misrepresents effects of anti-amyloid treatments due to lack of specificity of the PET imaging probe, effects of amyloid-related imaging abnormalities, spill-over from high white matter signals, and questionable quantification models.
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study
55/100 ✓ Peer-reviewed Biomarkers The journal of nutrition, health & aging
Key finding: Age-related frailty and disease-related frailty may represent different degrees of frailty severity on a biological level. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2022 no date recorded — placed by publication year
Education, Occupational Complexity, and Incident Dementia: A COSMIC Collaborative Cohort Study
70/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's Disease
Key finding: Using datasets from a wide range of geographical regions, we found that both early life education and adulthood occupational complexity were independently predictive of dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2022-01-01
Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease
82/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: Alzheimer's disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
December 2021 7
-
2021-12-31
Causal association of cognitive reserve on Alzheimer's disease with putative sex difference
45/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: AD was associated with lower PRS for premorbid cognitive performance, intelligence, and educational attainment. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2021-12-31
Reproducibility and replicability of high-frequency, in-home digital biomarkers in reducing sample sizes for clinical trials
45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)
Key finding: For the reproducibility, identical P-values and slope estimates were found with both digital biomarkers and neuropsychological test measures between the previous and current studies. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2021-12-31
Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
43/100 ✓ Peer-reviewed Drug development RNA biology
Key finding: RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently undruggable with small molecule-based drugs or monoclonal antibodies. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2021-12-31
Possible association between PM2.5 and neurodegenerative diseases: A systematic review
62/100 ✓ Peer-reviewed Inflammation and the immune system Environmental research
Key finding: Selected studies have highlighted how PM 2.5 exposure can be associated with the onset of neurodegenerative diseases (AD, PD, MS, VaD). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2021-12-30
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
43/100 ✓ Peer-reviewed Risk factors Molecules (Basel, Switzerland)
Key finding: Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2021-12-28
Me & My Wishes: Concordance of End-of-Life Preferences between Residents with Dementia, Family, and Staff
77/100 ✓ Peer-reviewed Health systems and care delivery Journal of palliative medicine
Key finding: Thirty-six resident videos were shared with family (N = 50) and staff (N = 38) during care plan meetings. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2021-12-28
TUBE Project: Transport-Derived Ultrafines and the Brain Effects
41/100 ✓ Peer-reviewed Risk factors International journal of environmental research and public health
Key finding: Moreover, the role of the semivolatile fraction of the emissions has been neglected. +4 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →