Home › Research › Biomarkers
Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers
Erin M Jonaitis, Henrik Zetterberg, Rebecca Langhough Koscik, Tobey J Betthauser, Carol A Van Hulle, Kirk Hogan, Laura Hegge, Gwendlyn Kollmorgen et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2022-02-09
Topic: Plasma and spinal-fluid biomarkers
Results suggested bias due to tube type, but crosswalks are possible for some analytes, with excellent model fit for NfL ( R 2 = 0.94), adequate for amyloid ( R 2 = 0.40-0.69), and weaker for t-tau ( R 2 = 0.04-0.42) and p - ta u 181 ( R 2 = 0.22-0.29). Brain amyloidosis differentiated several measures, especially EDTA plasma pTa u 181 A β 42 ( d = 1.29). AD biomarker concentrations vary by tube type. However, correlations for some biomarkers support harmonization across types, suggesting cautious optimism for use in banked blood.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jonaitis, E. M., Zetterberg, H., Koscik, R. L., Betthauser, T. J., Van Hulle, C. A., Hogan, K., et al. (2022). Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12266
Vancouver
Jonaitis EM, Zetterberg H, Koscik RL, Betthauser TJ, Van Hulle CA, Hogan K, et al. Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers. Alzheimer's & dementia (Amsterdam, Netherlands). 2022. doi:10.1002/dad2.12266. PMID: 35155728.
BibTeX
@article{jonaitis2022-35155728,
author = {Jonaitis, Erin M and Zetterberg, Henrik and Koscik, Rebecca Langhough and Betthauser, Tobey J and Van Hulle, Carol A and Hogan, Kirk and Hegge, Laura and Kollmorgen, Gwendlyn and others},
title = {{Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2022},
doi = {10.1002/dad2.12266},
pmid = {35155728},
url = {https://doi.org/10.1002/dad2.12266}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Results suggested bias due to tube type, but crosswalks are possible for some analytes, with excellent model fit for NfL ( R 2 = 0.94), adequate for amyloid ( R 2 = 0.40-0.69), and weaker for t-tau ( R 2 = 0.04-0.42) and p - ta u 181 ( R 2 = 0.22-0.29).
- Brain amyloidosis differentiated several measures, especially EDTA plasma pTa u 181 A β 42 ( d = 1.29).
- AD biomarker concentrations vary by tube type.
- However, correlations for some biomarkers support harmonization across types, suggesting cautious optimism for use in banked blood.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants38
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 38 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35155728) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Biomarkers
Also tagged “p-tau217”
692 studies in the library carry the topic tag “p-tau217”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 692 tagged studies.