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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,176–9,200 of 27,380 studies, newest first · page 368 of 1096.

February 2022 25

  1. 2022-02-22

    TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

    ✓ Peer-reviewed TREM2 and immune genetics eLife

    Key finding: Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-02-22

    The Humanistic and Economic Burden of Alzheimer's Disease

    ✓ Peer-reviewed Mild cognitive impairment Neurology and therapy

    Key finding: As a result of these progressive deficits in cognitive, emotional, and physical function, AD dementia can cause functional disability and loss of independence. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-02-21

    Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study)

    ✓ Peer-reviewed Clinical trials BMJ open

    Key finding: Specifically, recent studies suggest that increased plasma concentrations of lipoprotein-Aβ compromise the brain microvasculature, resulting in extravasation and retention of the lipoprotein-Aβ moiety. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2022-02-21

    Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?

    ✓ Peer-reviewed Drug development Frontiers in neuroscience

    Key finding: With an increasing number of glaucoma patients and disease progression despite treatment, it is paramount to develop new and effective therapeutics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-02-21

    Immersive Virtual Reality-Based Cognitive Intervention for the Improvement of Cognitive Function, Depression, and Perceived Stress in Older Adults With Mild Cognitive Impairment and Mild Dementia: Pilot Pre-Post Study

    ✓ Peer-reviewed Prevention trials JMIR serious games

    Key finding: Both groups showed significant improvements in all cognitive function measurements (P<.001). +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-02-21

    Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model

    ✓ Peer-reviewed Prevention trials Food & function

    Key finding: Alzheimer's disease (AD) is the most prevalent form of dementia affecting people worldwide Therefore, the current research aimed to investigate potential therapeutic benefits of Salvia officinalis (SOL) cultivated in Jordan and Salvia microphylla (SML) cultivated in Egypt with regard to acetylcholinesterase activity, β-amyloid deposition and oxidative stress associated with scopolamine-induced AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2022-02-20

    Mechanical Ventilation and Survival in Patients With Advanced Dementia in Medicare Advantage

    ✓ Peer-reviewed Health systems and care delivery Journal of pain and symptom management

    Key finding: Enrollment in MA was associated with increased IMV use (Adjusted Odds Ratio(AOR)=1.11, 95% CI: 1.04-1.18), 30- (Adjusted Hazard Ratio(AHR)=1.09, 95% CI: 1.05-1.12) and 365-day mortality (AHR=1.12, 95% CI: 1.08-1.16) compared to TM. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2022-02-18

    Structural Basis for Chaperone-Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP

    ✓ Peer-reviewed Prevention trials Angewandte Chemie (International ed. in English)

    Key finding: Our findings thus provide mechanistic insight into the chaperone-independent engagement of a disordered protein by its E3 ligase.

    Full summary, score breakdown and related studies → Original source

  9. 2022-02-18

    Plasma p-tau231, p-tau181, PET Biomarkers, and Cognitive Change in Older Adults

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: Plasma p-tau231 showed more robust associations with PET biomarkers than p-tau181 in presymptomatic individuals.

    Full summary, score breakdown and related studies → Original source

  10. 2022-02-17

    Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies

    ✓ Peer-reviewed Biomarkers Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: Moreover, plasma P-tau levels are associated with tracer uptake on tau- and amyloid-PET as well as with brain atrophy, cognitive measures and longitudinal changes of these parameters.

    Full summary, score breakdown and related studies → Original source

  11. 2022-02-17

    Site of death among individuals with and without dementia in 2016–2018

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

    Key finding: Individuals living with dementia often have limited capacity to express their care preferences at the final stage of life, and therefore, are at risk of receiving end-of-life care that may not align with their preferences.1 While most people prefer to be at home in their final days of life,2 research has shown that individuals with dementia are less likely to die in a home or community setting compared to those without dementia.3, 4 Studies also suggest that the percentage of individuals with dementia who died in a home or community setting has been increasing over time.5, 6 This study sought to update the literature by examining the association between dementia status and site of death, and by comparing the trends in site of death between decedents with and without dementia using recent national data. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-02-17

    The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

    ✓ Peer-reviewed Drug development Nature reviews. Drug discovery

    Key finding: However, four anti-Aβ antibodies have been shown to mediate the removal of amyloid plaque from brains of patients with AD, and the FDA has recently granted accelerated approval to one of these, aducanumab, using reduction of amyloid plaque as a surrogate end point. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-02-17

    Applications of artificial intelligence to aid early detection of dementia: A scoping review on current capabilities and future directions

    ✓ Peer-reviewed Digital health tools Journal of biomedical informatics

    Key finding: Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period before significant cognitive decline occurs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-02-16

    Prevalence, content and significance of advance care planning in nursing home patients

    ✓ Peer-reviewed End-of-life care Scandinavian journal of primary health care

    Key finding: Of the study population, 97% had a limited care plan (ACP I) documented. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-02-16

    Stress-Busting Program for Family Caregivers: Validation of the Spanish version using biomarkers and quality-of-life measures

    ✓ Peer-reviewed Caregiving Research in nursing & health

    Key finding: Hispanic family caregivers of people with dementia experience higher levels of stress compared to non-Hispanic white caregivers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-02-16

    Differences in Odor Identification in Early-Onset and Late-Onset Depression

    ✓ Peer-reviewed Risk factors Brain sciences

    Key finding: LOD patients exhibited lower OI scores than EOD patients and normal controls (NCs). +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2022-02-16

    Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

    Key finding: Previous studies showed that balancing microglia M1/M2 polarization had a promising therapeutic prospect in neurodegenerative diseases. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2022-02-16

    Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model

    ✓ Peer-reviewed Disease mechanisms Science translational medicine

    Key finding: Here, we showed that astrocytic α2-Na + /K + adenosine triphosphatase (α2-NKA) is elevated in postmortem human brain tissue from AD and progressive nuclear palsy, a primary tauopathy. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2022-02-16

    Function and therapeutic value of astrocytes in neurological diseases

    ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Drug discovery

    Key finding: Astrocyte dysfunction is found in numerous diseases, including multiple sclerosis, Alzheimer disease, Parkinson disease, Huntington disease and neuropsychiatric disorders. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2022-02-16

    Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies Hypertension (Dallas, Tex. : 1979)

    Key finding: On long-term follow-up (median 15 years; minimum-maximum, 0-20), participants developed cardiometabolic disease (hypertension [1255 events]; diabetes [381 events]), chronic kidney disease (529 events), dementia (235 events), cardiovascular disease (684 events) a +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2022-02-16

    Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: CSF biomarkers, including P-tau, T-tau, Aβ 42 , Aβ 40 , and NFL, support in vivo identification of AD neuropathology and correlate with FTLD neuropathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2022-02-15

    MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

    ✓ Peer-reviewed Treatments Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive decline as the primary clinical feature. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-02-14

    Association between the self-reported duration and quality of sleep and cognitive function among middle-aged and older adults in China

    ✓ Peer-reviewed Risk factors Journal of affective disorders

    Key finding: Sleep duration had an inverted U-shape relationship with cognitive scores (P <.001); and sleep quality had a positive linear relationship with cognitive scores (P <.001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-02-14

    Genome-wide association study of brain arteriolosclerosis

    ✓ Peer-reviewed Genetics Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: B-ASC is associated with cognitive impairment and increased likelihood of clinical dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-02-14

    A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

    ✓ Peer-reviewed Genetics Nature

    Key finding: We discover two subtypes of human pericytes, marked by solute transport and extracellular matrix (ECM) organization; and define perivascular versus meningeal fibroblast specialization. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →