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Stratification of the Gut Microbiota Composition Landscape across the Alzheimer's Disease Continuum in a Turkish Cohort
Yıldırım S, Nalbantoğlu ÖU, Bayraktar A, Ercan FB, Gündoğdu A, Velioğlu HA, Göl MF, Soylu AE et al.. mSystems, 2022-02-08
Topic: Amyloid, tau and blood-test diagnosis
Our results provide a framework for precision nutrition approaches aiming to modulate the AD gut microbiota. Recent studies demonstrated that gut dybiosis can influence normal brain function through the so-called "gut-brain axis." Modulation of the gut microbiota, therefore, has drawn strong interest in the clinic in the management of the disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yıldırım, S., ÖU, N., Bayraktar, A., Ercan, F. B., Gündoğdu, A., Velioğlu, H. A., et al. (2022). Stratification of the Gut Microbiota Composition Landscape across the Alzheimer's Disease Continuum in a Turkish Cohort. mSystems. https://doi.org/10.1128/msystems.00004-22
Vancouver
Yıldırım S, ÖU N, Bayraktar A, Ercan FB, Gündoğdu A, Velioğlu HA, et al. Stratification of the Gut Microbiota Composition Landscape across the Alzheimer's Disease Continuum in a Turkish Cohort. mSystems. 2022. doi:10.1128/msystems.00004-22. PMID: 35133187.
BibTeX
@article{yldrm2022-35133187,
author = {Yıldırım, S. and ÖU, Nalbantoğlu and Bayraktar, A. and Ercan, F. B. and Gündoğdu, A. and Velioğlu, H. A. and Göl, M. F. and Soylu, A. E. and others},
title = {{Stratification of the Gut Microbiota Composition Landscape across the Alzheimer's Disease Continuum in a Turkish Cohort}},
journal = {mSystems},
year = {2022},
doi = {10.1128/msystems.00004-22},
pmid = {35133187},
url = {https://doi.org/10.1128/msystems.00004-22}
}
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Key findings
- Our results provide a framework for precision nutrition approaches aiming to modulate the AD gut microbiota.
- Recent studies demonstrated that gut dybiosis can influence normal brain function through the so-called "gut-brain axis." Modulation of the gut microbiota, therefore, has drawn strong interest in the clinic in the management of the disease.
Why it matters
This study examined gut microbiota composition across the Alzheimer's disease continuum in a Turkish cohort. The authors state their results provide a framework for precision nutrition approaches aiming to modulate the Alzheimer's disease gut microbiota.
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Study details
- Participants27
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (mSystems) |
| Journal's citation record | 1 / 4 | MSystems: journal h-index 119 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 27 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 63 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 3.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 38 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Lütfü Hanoğlu: h-index 32 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | King's College London: institution h-index 1,348 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35133187) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
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