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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,826–9,850 of 27,380 studies, newest first · page 394 of 1096.

September 2021 25

  1. 2021-09-07

    Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis

    ✓ Peer-reviewed Disease mechanisms Cerebellum (London, England)

    Key finding: This revealed dendritic defects (P = 0.03), reduced C9orf72 in human patients (P = 0.005) and DPR-related neuronal loss (P = 0.0006) but no neuromuscular junction abnormalities (P = 0.29) or cerebellar neuronal loss (P = 0.23). +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-09-07

    A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

    ✓ Peer-reviewed Brain tissue and pathology Nature genetics

    Key finding: Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-09-07

    Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study

    ✓ Peer-reviewed Long-term cohort studies Frontiers in neurology

    Key finding: Plasma-based biomarkers would be potential biomarkers for early diagnosis of Alzheimer's disease (AD) because they are more available and cost-effective than cerebrospinal fluid (CSF) or neuroimaging. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-09-07

    Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Although all p-tau variants increased across the AD continuum, p-tau217 Lilly showed the greatest dynamic range (13-fold increase vs 1.9-5.4-fold increase for other p-tau variants for AD dementia vs non-AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2021-09-06

    GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH

    ✓ Peer-reviewed Drug development Frontiers in endocrinology

    Key finding: Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-09-06

    Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice

    ✓ Peer-reviewed Disease mechanisms Brain, behavior, and immunity

    Key finding: We observed that FMT from 5xFAD mice into normal C57BL/6 mice (5xFAD-FMT) decreased adult hippocampal neurogenesis and brain-derived neurotrophic factor expression and increased p21 expression, resulting in memory impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-09-06

    Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals

    ✓ Peer-reviewed Biomarkers Brain communications

    Key finding: We demonstrated that higher amyloid burden as measured by both CSF amyloid beta 42/40 ratio and non-displaceable binding potential in the posterior cingulate cortex was associated with lower functional connectivity in the default mode network. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-09-05

    Medical and nursing home costs: From cognitively unimpaired through dementia

    ✓ Peer-reviewed Costs and economics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Costs/follow-up day distributions differed significantly across cognitive categories. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-09-05

    Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models

    ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-09-04

    Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease

    ✓ Peer-reviewed Biomarkers Movement disorders : official journal of the Movement Disorder Society

    Key finding: Plasma NfL is a useful prognostic biomarker for PD, predicting clinical conversion to mild cognitive impairment or dementia. © 2021 International Parkinson and Movement Disorder Society.

    Full summary, score breakdown and related studies → Original source

  11. 2021-09-03

    Self-reported dual sensory impairment, dementia, and functional limitations in Medicare beneficiaries

    ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

    Key finding: Overall, 7124 participants representative of Medicare beneficiaries 65 years or older were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-09-03

    Longitudinal association of apolipoprotein E and sleep with incident dementia

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: During a median of 10.8 years follow-up, sleeping more or fewer than 7 hours was associated with a higher dementia risk (hazard ratio [HR] for 5 vs 7 hours: 1.35, 95% confidence interval [CI] 1.11-1.64; HR for 9 vs 7 hours: 1.59; 95% CI 1.37-1.85) as was daytime napping (HR for often/all of the time vs never/rarely: 1.67; 95% CI 1.37-2.03). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-09-03

    Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

    ✓ Peer-reviewed Tau biomarkers Molecular psychiatry

    Key finding: We analyzed gene expression data derived from autopsied brains donated by 982 individuals including 135 APOE ɛ2/ɛ3 carriers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-09-02

    Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease

    ✓ Peer-reviewed TREM2 and immune genetics The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    Key finding: Loss-of-function variants of TREM2 are associated with an increased risk of AD.

    Full summary, score breakdown and related studies → Original source

  15. 2021-09-02

    APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis

    ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Here, we report that the acute exposure of primary cortical neurons or synaptoneurosomes to APOE4 leads to a significant decrease in global protein synthesis.

    Full summary, score breakdown and related studies → Original source

  16. 2021-09-02

    Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial

    ✓ Peer-reviewed Cognitive tests and assessment The lancet. Healthy longevity

    Key finding: Between March 1, 2016, and March 12, 2020, 383 patients were enrolled and randomly assigned to the intervention or control group. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-09-02

    Association of postoperative delirium with cognitive outcomes: A meta-analysis

    ✓ Peer-reviewed Clinical safety Journal of clinical anesthesia

    Key finding: Main results Eighteen studies were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-09 month only

    The Relationship Between States' Staffing Regulations And Hospitalizations Of Assisted Living Residents

    ✓ Peer-reviewed Health systems and care delivery Health affairs (Project Hope)

    Key finding: We found that increased regulatory specificity for direct care workers (for example, a change from requiring "sufficient" direct care worker staffing to requiring a specific staffing ratio or level) was associated with a 4 percent reduction in the monthly risk for hospitalization among residents in our sample and a 6 percent reduction among the subgroup with dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-09-01

    Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study

    ✓ Peer-reviewed Risk factors The Lancet. Infectious diseases

    Key finding: This prospective, community-based, nested, case-control study used self-reported data (eg, on demographics, geographical location, health risk factors, and COVID-19 test results, symptoms, and vaccinations) from UK-based, adult (≥18 years) users of the COVID Symptom Study mobile phone app. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-09-01

    European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment

    ✓ Peer-reviewed Clinical safety European stroke journal

    Key finding: We found no evidence around routine cognitive screening following stroke but recognise the importance of targeted cognitive assessment.

    Full summary, score breakdown and related studies → Original source

  21. 2021-09-01

    The Effectiveness of e-Health Solutions for Aging With Cognitive Impairment: A Systematic Review

    ✓ Peer-reviewed Prevention trials The Gerontologist

    Key finding: Because technology is developing at a fast pace, the aim of this review was to present an overview of the research regarding the effectiveness of these solutions.

    Full summary, score breakdown and related studies → Original source

  22. 2021-09-01

    Admissions to High‐Quality Nursing Homes from Community: Racial Differences and Medicaid Policy Effects

    ✓ Peer-reviewed Risk factors Health Services Research

    Key finding: Key independent variables included the interaction of NH quality (measured by 5‐star rating) and race (i.e. black versus white), and interaction of NH quality, race, and state Medicaid dementia‐related add‐on policies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-09-01

    Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline

    ✓ Peer-reviewed Long-term cohort studies The Journal of clinical endocrinology and metabolism

    Key finding: Chronic obesity is associated with several complications, including cognitive impairment and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-09-01

    β-Amyloid in Cerebrospinal Fluid: How to Keep It Floating (Not Sticking) by Standardization of Preanalytic Processes and Collection Tubes

    ✓ Peer-reviewed Tau biomarkers The journal of applied laboratory medicine

    Key finding: Phosphorylated tau (pTau), total tau (tTau), and β-amyloid (Aβ) are established cerebrospinal fluid (CSF) biomarkers used to help diagnose Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-09-01

    Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies

    ✓ Peer-reviewed Tau biomarkers Journal of neuropathology and experimental neurology

    Key finding: Autopsy studies have identified a spectrum of tau pathologies in ET and tau isoforms have not been examined in ET. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →