Newest studies

Racial and Ethnic Disparities in Advance Care Planning: Assessing the Role of Subjective Life Expectancy

52/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Black and Hispanic older adults have significantly lower rates of ACP relative to Whites. +4 more findings

• Health Equity

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Sibling Deaths, Racial/Ethnic Disadvantage, and Dementia in Later Life

41/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Discrete-time hazard regression results show that sibling loss in mid-to-late life is associated with up to 54% higher risk for dementia. +4 more findings

• Health Equity

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Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment

41/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

Key finding: While the mechanisms for NLRP3 activation are not fully understood, it has been demonstrated that, after detection of protein aggregates, NLRP3 induces pro-inflammatory cytokines, such as interleukin 18 (IL-18) or interleukin 1β (IL-1β), that further potentiate AD progression. +1 more finding

• Brain Biology
• Treatments

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Stage-independent biomarkers for Alzheimer's disease from the living retina: an animal study

41/100 ✓ Peer-reviewed Brain scans and imaging Scientific reports

Key finding: Optical coherence tomography (OCT) is now common and widely available and has been used to image the retina of AD patients and healthy controls to search for biomarkers of neurodegeneration. +4 more findings

• Biomarkers
• Brain Biology

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Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease

66/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: We found that 50 of 313 (∼16%) FTP scans had high levels of skull signal. +4 more findings

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An accurate fully automated panel of plasma biomarkers for Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The high accuracies for Aβ pathology and future AD dementia using fully automated instruments are promising for implementing plasma biomarkers in clinical trials and clinical routine. +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

64/100 ✓ Peer-reviewed Biomarkers Nature medicine

Key finding: Previous biofluid data suggest that phosphorylated tau231 (p-tau231) could indicate incipient Aβ pathology, but a comprehensive comparison with other putative blood biomarkers is lacking. +2 more findings

• Biomarkers
• Early Stage

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Plasma P-Tau181 for the Discrimination of Alzheimer’s Disease from Other Primary Dementing and/or Movement Disorders

39/100 ✓ Peer-reviewed Biomarkers Biomolecules

Key finding: Plasma (but not serum) pT181-Tau showed a significant increase in Alzheimer’s disease and correlated significantly with cerebrospinal fluid amyloid and pT181-Tau. +1 more finding

• Biomarkers

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Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice

40/100 ✓ Peer-reviewed Disease mechanisms Brain, behavior, and immunity

Key finding: Our current study revealed that Indoles (including indole, indole-3-acetic acid and indole-3-propionic acid) upregulated the production of aryl hydrocarbon receptor (AhR), inhibited the activation of the NF-κB signal pathway as well as the formation of the NLRP3 inflammasome, reduced the release of inflammatory cytokines, including TNF-α, IL-6, IL-1β and IL-18, alleviating the inflammatory response of APP/PS1 mice. +1 more finding

• Brain Biology
• Digital Tools

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Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease

55/100 ✓ Peer-reviewed Brain scans and imaging Molecular psychiatry

Key finding: We observed that higher CSF GFAP levels were associated with elevated Aβ-PET but not tau-PET load. +3 more findings

• Biomarkers
• Brain Scans
• Brain Biology

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Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

48/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in aging neuroscience

Key finding: Prior research shows that females are more impacted by MCI than males. +3 more findings

• Early Stage

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Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

41/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in cellular and infection microbiology

Key finding: Pg OMVs impaired memory and learning ability of mice and decreased tight junction-related gene expression ZO-1, occludin, claudin-5, and occludin protein expression in the hippocampus. +4 more findings

• Brain Biology

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Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study

66/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry

Key finding: DNS-br total score and majority of the 11 DNS-br neurocognitive subdomain scores were significantly associated with FDG-PET resilience signature, PIB ratio, cerebral gray matter and white matter volume after adjusting for multiple testing. +4 more findings

• Brain Scans
• Digital Tools

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Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology

41/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

Key finding: The three visits prior to death revealed decline of language measures, with marked progression of atrophy. +2 more findings

• Brain Biology
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Alzheimer's disease medication use and adherence patterns by race and ethnicity

55/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Among newly diagnosed ADRD patients (n = 1299), 26% filled an ADRD prescription ≤90 days and 36% ≤365 days after diagnosis. +4 more findings

• Health Equity
• Treatments

Full summary, score breakdown and related studies → Original source

Excess Mortality Among Assisted Living Residents With Dementia During the COVID-19 Pandemic

57/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: Of the 286,350 residents in 2019 and the 273,601 in 2020 identified in these cohorts, approximately 31% had a diagnosis of ADRD. +4 more findings

• Care Services

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Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies

60/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: ARIA-E can also occur spontaneously in cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare autoimmune encephalopathy associated with increased CSF levels of anti-Aβ autoantibodies. +4 more findings

• Brain Biology
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Using Alzheimer's disease blood tests to accelerate clinical trial enrollment

43/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Incorporating AD blood tests into screening for AD clinical trials may reduce the time and financial cost of enrollment.

• Clinical Trials
• Biomarkers

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Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias

50/100 ✓ Peer-reviewed Brain tissue and pathology Parkinsonism & related disorders

Key finding: Age of acquisition of nouns (p = 0.034, |d| = 0.77) and lexical density (p = 0.0064, |d| = 0.72) were reduced in SYN + AD, and together showed excellent discrimination for SYN + AD vs. +4 more findings

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Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts

54/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: Identification of the precise, time-dependent composition of inflammatory cells may provide clues for the establishment of new biomarkers and therapeutic approaches targeting post-MI HF. +3 more findings

• Genetics
• Brain Biology

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Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America

41/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer's research & therapy

Key finding: We identified five novel variants in the presenilin1 (PSEN1) gene from Brazilian and Mexican families. +4 more findings

• Genetics

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TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages

43/100 ✓ Peer-reviewed TREM2 and immune genetics mBio

Key finding: A recent study showed that TREM2 is a receptor for mycolic acids in the mycobacterial cell wall and inhibits macrophage activation.

• Genetics

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Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

58/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity

Key finding: The phenotypes, localization, and functions of each population in different contexts have yet to be resolved. +3 more findings

• Brain Biology

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A Web-Based Platform (CareVirtue) to Support Caregivers of People Living With Alzheimer Disease and Related Dementias: Mixed Methods Feasibility Study

55/100 ✓ Peer-reviewed Treatments JMIR aging

Key finding: Care networks ranged from 1 to 8 members. +4 more findings

• Clinical Trials
• Caregiving

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Metformin and Dementia Risk: A Systematic Review with Respect to Time Related Biases

73/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease reports

Key finding: Seventeen studies were identified: thirteen cohort studies, two case-control studies, and two nested case-control studies. +4 more findings

• Risk Factors

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