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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,226–9,250 of 27,380 studies, newest first · page 370 of 1096.

February 2022 25

  1. 2022-02-07

    Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases

    ✓ Peer-reviewed Disease mechanisms Journal of cell science

    Key finding: Recent advances have revealed common pathological changes in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis with related frontotemporal dementia (ALS/FTD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-02-07

    Cholesterol metabolism in aging simultaneously altered in liver and nervous system

    ✓ Peer-reviewed Long-term cohort studies Aging

    Key finding: Studies in rodents showed that aging led to cholesterol accumulation in the liver and decrease in the brain with reduced cholesterol synthesis and increased levels of cholesterol 24-hydroxylase, an enzyme responsible for removing cholesterol from the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-02-07

    Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment

    ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

    Key finding: Intracranial atherosclerotic stenosis (ICAS) is one of the most frequent causes of stroke worldwide and confers one of the greatest risks of recurrent stroke compared with other causes of stroke.

    Full summary, score breakdown and related studies → Original source

  4. 2022-02-07

    Screening for deficits on intrinsic capacity domains and associated healthcare costs

    ✓ Peer-reviewed Treatments Archives of gerontology and geriatrics

    Key finding: This study showed that some deficits on IC domains, as measured by simple screening tests and questions, can be associated with higher healthcare costs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-02-07

    Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Over 10 years of close clinical dementia surveillance in this cohort study, loneliness was associated with increased dementia risk; this tripled in adults whose baseline risk would otherwise be relatively low on the basis of age and genetic risk, representing a majority of the US population. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-02-06

    A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-02-05

    TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?

    ✓ Peer-reviewed Disease mechanisms Cell calcium

    Key finding: Dysfunctional lysosomal proteins and enzymes result in the lysosomal accumulation of undigested macromolecules, e.g. lipids, glycoproteins, glycosaminoglycans, or gangliosides.

    Full summary, score breakdown and related studies → Original source

  8. 2022-02-05

    Metformin in Alzheimer's disease: An overview of potential mechanisms, preclinical and clinical findings

    ✓ Peer-reviewed Drug development Biochemical pharmacology

    Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-02-05

    The Potential Role of Gut Microbiota in Alzheimer's Disease: From Diagnosis to Treatment

    ✓ Peer-reviewed Disease mechanisms Nutrients

    Key finding: Gut microbiota is emerging as a key regulator of many disease conditions and its dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-02-05

    Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: The role of physical exercise in the prevention of Alzheimer's disease (AD) has been widely studied. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2022-02-04

    Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis

    ✓ Peer-reviewed Brain tissue and pathology Neurology

    Key finding: A total of 408 participants were included (n = 221 were LATE-NC+/HS-, n = 145 were LATE-NC+/HS+, and n = 42 were LATE-NC-/HS+). +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-02-04

    TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration

    ✓ Peer-reviewed Brain tissue and pathology NeuroImage. Clinical

    Key finding: FTLD-TDP was associated with faster atrophy rates in the inferior temporal lobe and temporal pole compared to all non-FTLD TDP-43 groups. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-02-04

    Cognitively stimulating environments and cognitive reserve: the case of personal social networks

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: Using neuroimaging data from 135 older adults participating in the Social Networks in Alzheimer Disease (SNAD) study, this article adopted a residual method for measuring CR and found that large network size, high network diversity, and loosely connected networks were positively associated with greater CR. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2022-02-04

    Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

    ✓ Peer-reviewed Drug development Vitamins and hormones

    Key finding: The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone very well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-02-04

    Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial

    ✓ Peer-reviewed Treatments JMIR research protocols

    Key finding: The intervention in the Digital, Cognitive, Multi-domain Alzheimer Risk Velocity is uniquely designed to reduce the risk of AD through a web-based health coaching experience that addresses the modifiable lifestyle-based risk factors. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-02-03

    Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

    ✓ Peer-reviewed Genetics Nature neuroscience

    Key finding: Nearly half of the protein co-expression modules, including modules significantly altered in AD, were not observed in RNA networks from the same cohorts and brain regions, highlighting the proteopathic nature of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2022-02-03

    Revised recommendations on standards and norms for palliative care in Europe from the European Association for Palliative Care (EAPC): A Delphi study

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: Most recommendations on standards and norms for palliative care in Europe remain unchanged since 2009.

    Full summary, score breakdown and related studies → Original source

  18. 2022-02-03

    Novel Nutraceutical Compounds in Alzheimer Prevention

    ✓ Peer-reviewed Prevention trials Biomolecules

    Key finding: Antiprotein aggregation molecules whose mechanisms were described are important. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2022-02-03

    Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

    ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews

    Key finding: A growing body of evidence indicates that dietary patterns have significant effects on cognitive function and the risk of developing AD.

    Full summary, score breakdown and related studies → Original source

  20. 2022-02-03

    Initiating second-line antidiabetic medication among older adults with type 2 diabetes on Metformin

    ✓ Peer-reviewed Health systems and care delivery BMC Geriatrics

    Key finding: Over half of participants (54%) received SFU as initial second-line ADM, 14% received BI, and 32% received another ADM. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2022-02-03

    Walking and Talking: Recommendations for Doing Mobile Interviews with Older Adults

    ✓ Peer-reviewed Risk factors Journal of Aging and Environment

    Key finding: Mobile methods, including walking interviews, have rarely been used in research with older adults. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2022-02-03

    Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

    ✓ Peer-reviewed Brain tissue and pathology The EMBO journal

    Key finding: The major aggregating protein in amyotrophic lateral sclerosis and frontotemporal dementia, the RNA-binding protein TAR DNA-binding protein (TDP-43), is hyperphosphorylated in disease on several C-terminal serine residues, a process generally believed to promote TDP-43 aggregation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-02-02

    Remote Assessment of Cardiovascular Risk Factors and Cognition in Middle-Aged and Older Adults: Proof-of-Concept Study

    ✓ Peer-reviewed Risk factors JMIR formative research

    Key finding: CVRF prevalence was 62.8% (n=150) for high cholesterol, 45.2% (n=108) for hypertension, 10.9% (n=26) for atrial fibrillation, and 7.5% (n=18) for diabetes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-02-02

    Systematic review of pharmacological interventions for people with Lewy body dementia

    ✓ Peer-reviewed Treatments Aging & mental health

    Key finding: We screened 18,884 papers and included 135 studies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-02-02

    Association of CSF, Plasma, and Imaging Markers of Neurodegeneration With Clinical Progression in People With Subjective Cognitive Decline

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: We included 401 individuals (61±9 years, 42% female, MMSE 28 ± 2, vascular comorbidities 8%-19%). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →