Newest studies

Alzheimer's Disease: Epidemiology and Clinical Progression

55/100 ✓ Peer-reviewed Getting a diagnosis Neurology and therapy

Key finding: Data on progression from preclinical AD to MCI are sparse, but an analysis of progression across the three preclinical National Institute on Aging and Alzheimer's Association (NIA-AA) stages suggests that NIA-AA stage 3 (subtle cognitive decline with AD biomarker positivity) could be useful in combination with other tools for treatment decision-making. +1 more finding

• Diagnosis
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

2022 Alzheimer's disease facts and figures

57/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. +4 more findings

Full summary, score breakdown and related studies → Original source

Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia

52/100 ✓ Peer-reviewed Costs and economics International journal of environmental research and public health

Key finding: In total, 1006 elderly were interviewed, with a 66.18% response rate. +4 more findings

Full summary, score breakdown and related studies → Original source

Disrupted olfactory functional connectivity in patients with late-life depression

50/100 ✓ Peer-reviewed Risk factors Journal of affective disorders

Key finding: Compared with LLD patients without OI impairment and normal controls, LLD patients with OI impairment exhibited increased FC between the left orbital frontal cortex (OFC) and left calcarine gyrus, between the left OFC and right lingual gyrus, between the right OFC and right rectus gyrus, and decreased FC between the right piriform cortex and right superior parietal lobule. +4 more findings

Full summary, score breakdown and related studies → Original source

Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

63/100 ✓ Peer-reviewed Long-term cohort studies EClinicalMedicine

Key finding: Identifying independent and interactive associations of a wide range of diseases and multimorbidity and apolipoprotein E4 (APOE4) with dementia may help promote cognitive health. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Out-of-pocket costs attributable to dementia: A longitudinal analysis

48/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: We identified a cohort of 3619 incident dementia cases, 38.9% were male, and 66.9% were non-Hispanic White. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Interventions to reduce loneliness in caregivers: An integrative review of the literature

41/100 ✓ Peer-reviewed Risk factors Psychiatry research

Key finding: Older adults are at an increased risk of loneliness. +2 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer

46/100 ✓ Peer-reviewed TREM2 and immune genetics Cancer immunology, immunotherapy : CII

Key finding: Immune checkpoint blockade (ICB) has been improving patient outcomes of non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual tumor microenvironment. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2

41/100 ✓ Peer-reviewed Vascular contributions Cerebral circulation - cognition and behavior

Key finding: rTg-D rats begin to accumulate Aβ in brain and develop varying levels of larger vessel CAA type-2, in the absence of capillary CAA type-1, starting around 18 months of age. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review

70/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Seventy-six articles met the inclusion criteria for systematic review. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

The China Alzheimer Report 2022

43/100 ✓ Peer-reviewed Disparities General psychiatry

Key finding: More specifically, it examines the public health impact of ADRD, including prevalence, mortality, costs, usage of care, and the overall effect on caregivers and society.

• Policy

Full summary, score breakdown and related studies → Original source

Neuropathology Studies of Dementia in US Persons other than Non-Hispanic Whites

41/100 ✓ Peer-reviewed Disparities Free neuropathology

Key finding: We sought to characterize current knowledge of the neuropathologic landscape of AD and vascular dementia of the largest growing US minority groups, namely Latinos/Hispanics, Black Americans, and Asian Americans, compared with NHWs being the majority group. +1 more finding

• Health Equity
• Brain Biology

Full summary, score breakdown and related studies → Original source

Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease

82/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Subsequent in vitro functional analysis revealed that the MLKL stop-gain variant can contribute to increases not only in abnormal cells that should die by programmed cell death but do not, but also in the ratio of Aβ42 to Aβ40. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model

41/100 ✓ Peer-reviewed Inflammation and the immune system ACS chemical neuroscience

Key finding: Several studies have demonstrated the health benefits of olive oil and olive leaf extract (OLE) due to their polyphenolic content. +1 more finding

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Tau and the fractionated default mode network in atypical Alzheimer's disease

45/100 ✓ Peer-reviewed Brain scans and imaging Brain communications

Key finding: Furthermore, higher tau signal and reduced grey matter density in the posterior cingulate cortex and angular gyrus were associated with reduced parietal functional connectivity across individual patients, related to poorer cognitive scores. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease

46/100 ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences

Key finding: Mutations in pathological genes, including amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2), were associated with EOAD. +1 more finding

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

A novel computer adaptive word list memory test optimized for remote assessment: Psychometric properties and associations with neurodegenerative biomarkers in older women without dementia

53/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: The SLS is a valid and reliable self-administered memory test that shows promise for remote assessment of aging and neurodegenerative disorders.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Economic Evaluation of Healthcare Resource Utilization and Costs for Newly Diagnosed Dementia-Related Psychosis

57/100 ✓ Peer-reviewed Costs and economics Geriatrics (Basel, Switzerland)

Key finding: These results indicate the importance of identifying newly diagnosed psychosis in dementia patients as well as the pressing need for management strategies and treatments that can reduce HCRU and costs.

• Policy

Full summary, score breakdown and related studies → Original source

Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies

64/100 ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society

Key finding: The annual increase of flortaucipir SUVr was greater in the middle and superior occipital, fusiform, and inferior parietal cortices in DLB (mean: 0.017, 0.019, 0.019, and 0.015, respectively) compared with the CU (mean: -0.006, -0.009, -0.003, and - 0.005, respectively; P < 0.05). +4 more findings

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Association Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study

67/100 ✓ Peer-reviewed Digital health tools Annals of internal medicine

Key finding: Dual-eligible older persons are at greater risk for decline in function and cognition after an ICU hospitalization than their more advantaged counterparts. +1 more finding

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Sex and Gender Differences in Environmental Influences on Dementia Incidence in Germany, 2014–2019: An Observational Cohort Study Based on Health Claims Data

47/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: After adjusting for multi-morbidity and relocation-related selection bias, we saw that people living in regions with the highest tertile of income (HR = 0.87, p < 0.001), and who had the highest tertile of remaining life expectancy at age 60 (HR = 0.93, p = 0.012) had lower dementia risks. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease

50/100 ✓ Peer-reviewed Tau biomarkers Neurology(R) neuroimmunology & neuroinflammation

Key finding: This study aims to quantify microglial activation in individuals with Alzheimer disease (AD) using the 18-kDa translocator protein (TSPO) PET imaging in the hippocampus and precuneus, the 2 AD-vulnerable regions, and to evaluate the association of baseline neuroinflammation with amyloidosis, tau, and longitudinal cognitive decline. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Our trial showed that olfactory-stimulated oxygenation differences in the orbitofrontal cortex detected by fNIRS were associated with cognitive impairment and cognitive-related objectives. +4 more findings

• Clinical Trials
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals

54/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: Our findings suggested that the different frequencies of Aβ (+) between CN Koreans and Europeans might be related to decreased cognitive reserve or genetic factors.

• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Rural depopulation and the rural‐urban gap in cognitive functioning among older adults

47/100 ✓ Peer-reviewed Risk factors The Journal of Rural Health

Key finding: Older adults living in rural counties had lower cognitive functioning than urban adults. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source