Newest studies

Key lessons to improve care—factors contributing to delayed discharges and cost implications: medical conditions and rehabilitation delays at a tertiary rehabilitation center in Saudi Arabia

48/100 ✓ Peer-reviewed Health systems and care delivery International Journal for Quality in Health Care

Key finding: TBI had the highest percentage (37%) compared to other conditions, which may be attributed to the prevalent challenge of cognitive impairment in TBI in addition to physical disability. +4 more findings

• Care Services
• Policy

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Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank

64/100 ✓ Peer-reviewed Long-term cohort studies Journal of the American Medical Informatics Association : JAMIA

Key finding: Knowledge gained from cohort studies has dramatically advanced both public and precision health. +3 more findings

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Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females

67/100 ✓ Peer-reviewed Long-term cohort studies Brain : a journal of neurology

Key finding: Despite a similar amyloid-β (Aβ) load, a higher load of neurofibrillary tangles (NFTs) is seen in females than males. +3 more findings

• Brain Biology

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Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer

55/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: Here, we analyze trajectory inference, deconvolute spatial transcriptomics at single-cell level and perform functional assays to generate a high-resolution integrated map of breast cancer (BC), with a focus on inflammatory and myofibroblastic (iCAF/myCAF) FAP+ CAF clusters. +3 more findings

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Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease

43/100 ✓ Peer-reviewed Biomarkers Alzheimer disease and associated disorders

Key finding: We demonstrated a moderate positive correlation between PDGFRβ and both total Tau and phosphorylated Tau 181 in cognitively normal individuals. +3 more findings

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

43/100 ✓ Peer-reviewed Treatments International journal of molecular sciences

Key finding: Two antibodies, aducanumab and lecanemab, have been approved by the U.S. +4 more findings

• Treatments

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Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden

55/100 ✓ Peer-reviewed Vascular contributions Neurobiology of aging

Key finding: Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = -.02, 95% CI (-.04, -.008), p =.003] and in APOE4 carriers [B = -.03, 95% CI (-.06, -.009), p =.009]. +1 more finding

• Brain Scans

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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome

50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature structural & molecular biology

Key finding: We found two Aβ 40 filaments (types IIIa and IIIb) that differ from those previously reported in sporadic AD and two types of Aβ 42 filaments (I and II) identical to those found in sporadic and familial AD.

• Down Syndrome

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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

54/100 ✓ Peer-reviewed Disparities Nature communications

Key finding: These results expand the structural characterization of LBD Asyn fibrils and approaches for studying disease mechanisms, imaging agents and therapeutics targeting Asyn.

• Other Dementias

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Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

45/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: Tau spatial spread may demonstrate earlier changes than tau burden which could have broad impact in clinical trial design.

• Brain Scans

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Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease

43/100 ✓ Peer-reviewed Brain scans and imaging Journal of clinical medicine

Key finding: Recent studies have found significant connections between NTG and cerebral manifestations, suggesting NTG as a neurodegenerative disease beyond the eye.

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Post‐acute care transitions during COVID ‐19: Racial, ethnic, and socioeconomic differences in older adults with Alzheimer's disease and related dementia

50/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: SNF discharges decreased while home and HHA discharges increased during the pandemic. +4 more findings

• Health Equity

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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology

59/100 ✓ Peer-reviewed TREM2 and immune genetics Nature neuroscience

Key finding: To circumvent these issues, here we generated 138,577 single-cell expression profiles of human stem cell-derived microglia xenotransplanted in the brain of the App NL-G-F model of amyloid pathology and wild-type controls. +3 more findings

• Brain Biology

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Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study

72/100 ✓ Peer-reviewed Prevention and risk BMJ

Key finding: The study findings suggest delirium was a strong risk factor for death and incident dementia among older adult patients. +2 more findings

• Risk Factors
• Care Services

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A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices

57/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

Key finding: The derived RDMC score is significantly correlated with the PACC5 score across participants and demonstrates good retest reliability.

• Diagnosis
• Digital Tools
• Early Stage

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ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study

41/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: It has been reported that the risk of Alzheimer's disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. +3 more findings

• Biomarkers

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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

46/100 ✓ Peer-reviewed Inflammation and the immune system Nature communications

Key finding: High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. +1 more finding

• Brain Biology

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Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau

46/100 ✓ Peer-reviewed Drug development Brain communications

Key finding: Synthetic in vitro-transcribed messenger RNA encoding antibodies for endogenous protein expression holds the potential to overcome many of the limitations associated with protein antibody production. +2 more findings

• Treatments

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Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: GFAP did not correlate with Aβ- or tau-PET cross-sectionally. +2 more findings

• Biomarkers

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Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia

58/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: This comprehensive analysis demonstrated that the variance in AD blood biomarker concentrations was mainly explained by age, with minor contributions from cognition, brain atrophy, and genetics, conversely to CSF measures. +2 more findings

• Biomarkers

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Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies

64/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: We identified which neuropathologic entities correlate most frequently with one another and demonstrated that the total number of pathologies per individual was directly correlated with cognitive performance as assessed by Clinical Dementia Rating (CDR®) and Mini-Mental State Examination (MMSE). +3 more findings

• Brain Biology
• Genetics

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Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis

73/100 ✓ Peer-reviewed Prevention and risk Aging Clinical and Experimental Research

Key finding: Despite the relatively low risk reduction associated with higher adherence to MedDiet among elderly, it should be considered that this population is the most affected. +2 more findings

• Lifestyle
• Prevention

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Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4. +2 more findings

• Genetics

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Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain

53/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: A new variant influences APOE expression only in microglia and is associated with greater cerebral amyloid angiopathy but not Alzheimer's disease pathology, after adjusting for APOEε4, providing mechanistic insights into both pathologies. +1 more finding

• Genetics

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Neuropsychiatric symptoms profile and markers of Alzheimer disease-type pathology in patients with Lewy body dementias

43/100 ✓ Peer-reviewed Tau biomarkers Brain research

Key finding: We enrolled 69 individuals diagnosed with Lewy body dementia (LBD), comprising both dementia with Lewy bodies (DLB) (n = 36) and Parkinson's disease dementia (PDD) (n = 33). +3 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source