Newest studies

High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia

45/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

Key finding: Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs. +4 more findings

Full summary, score breakdown and related studies → Original source

Development of a midlife-specific CogDrisk algorithm (CogDrisk-ML) to enable validated implementation of dementia risk assessment from midlife to late life

59/100 ✓ Peer-reviewed Brain tissue and pathology Age and Ageing

Key finding: CogDrisk-ML outperformed CAIDE in the UK Biobank and Whitehall II cohorts; however, it provided similar C statistics in the ARIC dataset. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Social determinants of dementia: A scoping review

47/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: HIGHLIGHTS: There is clear and consistent evidence for some social determinants of dementia (SDOD) across diverse domains. +4 more findings

• Health Equity

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Más allá del realismo y el constructivismo: el Alzheimer como resfactum en una ontología relacional de las entidades biomédicas

26/100 ✓ Peer-reviewed Risk genes beyond APOE Discusiones Filosóficas

Key finding: A partir de esta limitación, se propone un nuevo concepto denominado resfactum para dar cuenta del modo de existencia del Alzheimer. +4 more findings

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Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation

42/100 ✓ Peer-reviewed Risk genes beyond APOE Biomolecules

Key finding: A comprehensive biochemical analysis revealed that all five mutations led to substantially reduced initial proteolysis of C99 to Aβ49 or Aβ48 as well as deficiencies in one or more subsequent trimming steps. +2 more findings

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Perceived experiences of adults with mild cognitive impairment: a qualitative study

39/100 ✓ Peer-reviewed Mild cognitive impairment BMC Psychology

Key finding: The results of the data analysis revealed two main categories: emotional schemas in mild cognitive impairment and understanding the meaning of the diagnosis. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Gender differences in cognitive reserve: An impact on progression in subjective cognitive decline?

42/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Gender has an impact on CR, but not through socio‐economic variables. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative

44/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: A one‐point ALI increase was associated with MCI conversion odds by 15%.

• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source

A common outcome set for trials in dementia with Lewy bodies (DLB COS)

58/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Forty-nine outcomes were presented to survey respondents. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology

41/100 ✓ Peer-reviewed Lewy body dementia Molecular Neurodegeneration

Key finding: There is emerging evidence suggesting a range of further pharmacological and non-pharmacological therapies may be effective in treating specific symptom domains of DLB, but further evidence is warranted to demonstrate their efficacy. +4 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

It is time to share Alzheimer biomarker results in dementia with Lewy bodies

41/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: There are increasing calls for sharing individual biomarker results with participants in dementia research. +4 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia

44/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Early isolated functional disruptions in salience/visual networks were present in asymptomatic carriers, along with anterior cingulate gray matter reductions. +4 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Evaluating GLP-1 receptor agonists versus metformin as first-line therapy for reducing dementia risk in type 2 diabetes

52/100 ✓ Peer-reviewed Risk factors BMJ Open Diabetes Research & Care

Key finding: Among 87,229 matched patients per cohort, GLP-1 RA use was associated with a significantly lower risk of overall dementia (adjusted HR (AHR) 0.90; 95% CI 0.85 to 0.95), Alzheimer's disease (AD) (AHR 0.88; 95% CI 0.83 to 0.94), and non-vascular dementias (non-VaDs) (AHR 0.75; 95% CI 0.70 to 0.81) compared with metformin. +4 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Sex differences in modifiable dementia risk factors: Findings from the Rush Memory and Aging Project

53/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The analytical sample comprised 1481 NCI (76.7% female) and 515 MCI (69.7% female) participants. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Machine learning diagnosis of mild cognitive impairment using advanced diffusion MRI and CSF biomarkers

41/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: MAP-RTAP (AUC = 0.78) and pTau/Aβ42 (AUC = 0.76) were the best performing individual biomarkers. +3 more findings

• Biomarkers
• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Machine learning model for predicting Amyloid-β positivity and cognitive status using early-phase 18F-Florbetaben PET and clinical features

50/100 ✓ Peer-reviewed Digital health tools Scientific Reports

Key finding: Feature importance was assessed to identify key predictors, and the importance of features that most significantly influenced each model’s results was calculated. +1 more finding

• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Delirium and COVID-19: prevalence, outcomes and associated factors in a cohort of elderly inpatients

52/100 ✓ Peer-reviewed How common it is Minerva Psychiatry

Key finding: The study included 212 patients, with a mean age of 82.27 years. +4 more findings

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Estimating the impact of risk factor reduction on dementia prevalence in New Zealand

42/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: The PIF for the total NZ population following a 15% risk factor reduction was 14.6% (95% confidence interval: 7.7-21.1) Modeled projections demonstrated prevalence reduction over time, from 1.0% at 10 years to 4.2% at 30 years. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis

52/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: = 1661), 622 developed dementia within 5 years. +4 more findings

• Early Stage
• Risk Factors

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Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study

56/100 ✓ Peer-reviewed How common it is BMJ Neurology Open

Key finding: We identified 62 928 patients with OSA and 62 928 in the propensity score-matched comparison cohort (76% male, median age 52 years). +4 more findings

• Risk Factors

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Trend analysis and future predictions of global burden of alzheimer’s disease and other dementias: a study based on the global burden of disease database from 1990 to 2021

51/100 ✓ Peer-reviewed How common it is BMC Medicine

Key finding: The global burden of AD and other dementias has significantly increased, with the highest incidence, prevalence, and DALYs observed in East Asia. +4 more findings

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Spotlight on Alzheimer's disease and related dementias research in East Asia

38/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: With a burgeoning dementia burden driven by unique demographic, genetic, and socioeconomic factors of East Asia, the region has made significant investments in understanding disease mechanisms, developing biomarkers, and exploring therapeutic approaches.

• Health Equity

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Advancing dementia care: a review of Italy’s public health response within the WHO Global Action Plan and European strategies

40/100 ✓ Peer-reviewed Disparities BMJ Public Health

Key finding: IFAD activities led to substantial progress in dementia care services, with memory clinics, residential care facilities and daycare centres mapped, revealing regional disparities in service provision. +4 more findings

• Prevention
• Care Services

Full summary, score breakdown and related studies → Original source

Creating harmony at home via environmental cueing: A feasibility trial of a non‐pharmacological intervention for rural caregivers of persons with dementia

37/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Twenty-eight caregivers completed the intervention, which increased caregiver mastery and decreased stress and burden. +4 more findings

• Clinical Trials
• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Sensory impairment and dementia risk among older adults in rural South Africa

46/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Half of the participants were over 70, with no formal education. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source