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High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia
Christos Panagiotis Lisgaras, Sandra Giménez, María Carmona‐Iragui, Lucía Maure‐Blesa, Esther Blessing, Juan Fortea, Ricardo S. Osorio. Alzheimer s & Dementia, 2025-07-01
Topic: Brain proteins, microglia and lab models
Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs. HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases. A trend toward increasing HFO rates with age in DS warrants further confirmation. HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS. HIGHLIGHTS: Wideband polysomnography reveals a new electrical abnormality in DS. HFOs precede AD dementia in DS. The occurrence of HFOs in DS is independent of an epilepsy diagnosis. HFOs showed hemispheric lateralization in asymptomatic DS cases. A trend of increased HFO rate with advancing age warrants further investigation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lisgaras, C. P., Giménez, S., Carmona‐Iragui, M., Maure‐Blesa, L., Blessing, E., Fortea, J., et al. (2025). High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70386
Vancouver
Lisgaras CP, Giménez S, Carmona‐Iragui M, Maure‐Blesa L, Blessing E, Fortea J, et al. High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70386. PMID: 40642994.
BibTeX
@article{lisgaras2025-40642994,
author = {Lisgaras, Christos Panagiotis and Giménez, Sandra and Carmona‐Iragui, María and Maure‐Blesa, Lucía and Blessing, Esther and Fortea, Juan and Osorio, Ricardo S.},
title = {{High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70386},
pmid = {40642994},
url = {https://doi.org/10.1002/alz.70386}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs.
- HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases.
- A trend toward increasing HFO rates with age in DS warrants further confirmation.
- HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.
- HIGHLIGHTS: Wideband polysomnography reveals a new electrical abnormality in DS.
Why it matters
In a small study of 14 people with Down syndrome, high-frequency brain oscillations appeared before Alzheimer's dementia and were seen in all cases. The authors call these oscillations promising biomarkers that may predict dementia in adults with Down syndrome, but say the trend with age needs further confirmation.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 13 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 11.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ricardo S. Osorio: h-index 50 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | New York University: institution h-index 1,612 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40642994) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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