Newest studies

Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: None of the three plasma biomarker was associated with NPS at baseline. +4 more findings

• Biomarkers

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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes

57/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron

Key finding: Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and pathological conditions. +3 more findings

• Brain Biology

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A genome-wide association meta-analysis of all-cause and vascular dementia

80/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). +4 more findings

• Genetics
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Social Vulnerability and Prevalence and Treatment for Mental Health and Substance Use Disorders

58/100 ✓ Peer-reviewed Risk factors JAMA Psychiatry

Key finding: The analysis involved 4674 participants (2904 [62.13%] female and 1770 [37.87%] male; mean [SD] age, 41.51 [13.41] years). +4 more findings

• Treatments

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Single-cell multiregion dissection of Alzheimer's disease

69/100 ✓ Peer-reviewed Brain tissue and pathology Nature

Key finding: Here we report a single-cell transcriptomic atlas of six different brain regions in the aged human brain, covering 1.3 million cells from 283 post-mortem human brain samples across 48 individuals with and without Alzheimer's disease. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Reasons for undergoing amyloid imaging among diverse enrollees in the A4 study

46/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Compared to non-Hispanic or Latino (NH) White participants, Hispanic or Latino (3.52 points, 95% confidence interval [CI]: [2.61, 4.42]); NH Asian (2.97 points, 95% CI: [1.71, 4.22]); and NH Black participants (2.79 points, 95% CI: [1.96, 3.63]) participants demonstrated higher levels of endorsement of the VPAI items at baseline. +4 more findings

• Health Equity
• Brain Scans

Full summary, score breakdown and related studies → Original source

Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research square

Key finding: Using the SOMAscan assay, we detected subtle increases in specific ubiquitin enzymes associated with proteostasis in mutation carriers (MCs) up to two decades before the estimated symptom onset. +4 more findings

• Brain Biology
• Biomarkers
• Brain Scans

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model

46/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A strong linear relationship was observed between CTR values across brain regions. +4 more findings

• Brain Scans

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Polygenic scores and Mendelian randomization identify plasma proteins causally implicated in Alzheimer's disease

84/100 ✓ Peer-reviewed Genetics Frontiers in neuroscience

Key finding: We identified four plasma protein level PGSs that were significantly associated (FDR-adjusted p < 0.05) with LOAD in a meta-analysis of the discovery and replication cohorts: CX3CL1, hepatocyte growth factor (HGF), TIE2, and matrix metalloproteinase-3 (MMP-3). +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Predicting continuous amyloid PET values with CSF tau phosphorylation occupancies

55/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Concentration of CSF pT217/T217 had low predictive error (average error: 13%), but also a low predictive range (ceiling 63 Centiloids). +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis

41/100 ✓ Peer-reviewed Drug development Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Key finding: Newly conducted research suggests that metabolic disorders, like diabetes and obesity, play a significant role as risk factors for psychiatric disorders. +4 more findings

• Treatments
• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

PM2.5 triggers tau aggregation in a mouse model of tauopathy

43/100 ✓ Peer-reviewed Risk factors JCI insight

Key finding: Epidemiological data show that exposure to fine particulate matter (PM2.5) is associated with an increased risk of AD. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes

43/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology

Key finding: 47 retired contact sport athletes negative for AD (age:51 ± 14; concussions/athlete:15 ± 2) and 54 normal controls (age:50 ± 13) were included. +4 more findings

• Brain Scans

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Initial Perspectives From Rural-Residing Adults on a Digital Cognitive Health Coaching Intervention: Exploratory Qualitative Analysis

57/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR formative research

Key finding: The following four themes emerged from participants' feedback: (1) healthy lifestyle and behavioral changes, (2) a sense of self-awareness through introspection, (3) value in coach support, and (4) a desire for a change in program format (eg, frequency). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop

56/100 ✓ Peer-reviewed Digital health tools Nature reviews. Cardiology

Key finding: The National Heart, Lung, and Blood Institute conducted a workshop in October 2022 to examine this concept. +4 more findings

• Risk Factors
• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: TREM2 trimers remained stably bound, driven primarily by salt bridge between residues D87 and R76 at the interface of TREM2 units. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study

55/100 ✓ Peer-reviewed Risk factors European journal of neurology

Key finding: At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs). +4 more findings

• Risk Factors

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Incretin-Based Multi-Agonist Peptides Are Neuroprotective and Anti-Inflammatory in Cellular Models of Neurodegeneration

43/100 ✓ Peer-reviewed Drug development Biomolecules

Key finding: In addition, our results indicate that these multi-agonists have the potential to outperform commercially available single GLP-1R agonists in neurodegenerative disease treatment.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p-tau217 immunoassays

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: This study provides a systematic framework for selection of assay-specific cutpoints for clinical use of plasma p-tau217 for determination of amyloid status. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Medicare-Covered Services Near the End of Life in Medicare Advantage vs Traditional Medicare

48/100 ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

Key finding: Receipt of potentially burdensome hospitalizations and treatments; receipt of postdischarge home and facility care. +4 more findings

• Care Services
• End-of-Life Care

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Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants

77/100 ✓ Peer-reviewed Prevention and risk BMC medicine

Key finding: Increased absolute sugar intake (g/day) was significantly associated with a higher risk of all-cause dementia (HR = 1.003, [95%CI: 1.002-1.004], p < 0.001) and Alzheimer's disease (1.002, [1.001-1.004], 0.005). +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Eye-brain connections revealed by multimodal retinal and brain imaging genetics

46/100 ✓ Peer-reviewed Brain scans and imaging Nature communications

Key finding: Overall, our findings reveal the genetic basis for eye-brain connections, suggesting that retinal images can help uncover genetic risk factors for brain disorders and disease-related changes in intracranial structure and function.

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease

68/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In addition to the apolipoprotein E (APOE) locus, our GWAS of two independent Chinese samples uncovered three novel AD susceptibility loci (KIAA2013, SLC52A3, and TCN2) and a novel ancestry-specific variant within EGFR (rs1815157). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers Clinica chimica acta; international journal of clinical chemistry

Key finding: The study population consisted of 194 patients (123 AD and 71 non-AD). +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Late Life Depression is Not Associated With Alzheimer-Type Tau: Preliminary Evidence From a Next-Generation Tau Ligand PET-MR Study

47/100 ✓ Peer-reviewed Biomarkers The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Our findings suggest AD-type tau is not higher in LLD compared to non-depressed, cognitively unimpaired older adults and appears unlikely to contribute to lower gray matter volume in LLD, further underscoring the need to distinguish major depressive disorder from depressive symptoms occurring in early AD. +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source