Newest studies

Association of midlife hearing impairment and hearing aid use with incident dementia: analysis of two UK-based longitudinal cohort studies

63/100 ✓ Peer-reviewed Risk factors Nature aging

Key finding: We found modest associations and population attributable fractions for reported and measured 'midlife' hearing impairment, highlighting the need to consider age at measurement of risk factors in studies that target dementia prevention.

• Risk Factors
• Lifestyle

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Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial

73/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Gantenerumab significantly reduced PiB-PET uptake overall and in most regions and showed no changes in FDG-PET or MRI measures. +4 more findings

• Brain Scans
• Treatments
• Clinical Trials

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Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome

59/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Three genome-wide significant associations were identified for p-tau181: TUBAP/rs76523946, P = 2.21E-08; CTNND2/rs142510573, P = 3.04E-08; CLSTN2/rs112448655, P = 3.04E-08, and one for t-tau (JHY/rs77264104, P = 2.84E-08). +4 more findings

• Genetics
• Biomarkers
• Brain Scans

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Focused ultrasound-mediated APOE4 knockdown in mouse brain

50/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: FUS-enhanced delivery of AAV resulted in a 12.6% knockdown of APOE ε4 gene expression in the targeted hippocampus, accompanied by an over 20% decrease in apoE4 protein levels and significant reductions in astrocyte and microglia levels. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Smartphone Keystroke-based Cognitive Impairment Diagnostic Methodology

43/100 ✓ Peer-reviewed Cognitive tests and assessment Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Key finding: Significant efforts are being made to address the health and other problems associated with dementia. +3 more findings

• Diagnosis
• Digital Tools

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Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Both Mann-Whitney tests and ANCOVA found significant differences between groups racialized as AA or NWH with respect to global 11[C]-Pittsburgh Compound B (PiB) standardized uptake value ratio (SUVR), cortical thickness values, p-tau181, and p-tau231 values (p < 0.05). +2 more findings

• Biomarkers
• Brain Scans

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Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: E280A carriers had higher p-tau231 levels than non-carriers (9.0 ± 7.4 vs. 5.2 ± 3.4 pg/mL, P < 0.001). +4 more findings

• Biomarkers
• Genetics

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Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Relative to cybrids expressing mtDNA from CH individuals, MCI and AD cybrids contained more phosphorylated tau-217 (p-tau217), p-tau181, and total tau. +4 more findings

• Brain Biology
• Biomarkers

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[Speech therapy after memory consultation: characteristics of patients receiving speech therapy sessions]

33/100 ✓ Peer-reviewed Health systems and care delivery Geriatrie et psychologie neuropsychiatrie du vieillissement

Key finding: Univariate analyses showed that speech therapy was more frequent in men, in patients with higher or secondary education, in patients suffering from Alzheimer's disease (AD) and having a higher MMSE. +3 more findings

• Treatments

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Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities

46/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: The plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. +4 more findings

• Other Dementias
• Biomarkers
• Brain Scans

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Advance care planning and goals of care discussions with patients living with dementia

30/100 ✓ Peer-reviewed End-of-life care Canadian Family Physician

Key finding: How should I approach advance care planning (ACP) and goals of care (GOC) discussions with patients living with dementia? +2 more findings

• End-of-Life Care

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Formal caregivers’ knowledge, attitudes, and challenges in end-of-life care for people with advanced dementia: a qualitative study in Chinese nursing home

33/100 ✓ Peer-reviewed End-of-life care BMC Nursing

Key finding: Various negative and positive aspects, along with specific needs, were identified. +4 more findings

• End-of-Life Care
• Caregiving
• Care Services

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Seeing the trees in the wood: the importance of co-pathologies in Alzheimer’s disease and dementia with Lewy bodies

53/100 ✓ Peer-reviewed Clinical safety Brain

Key finding: In contrast, patients with LB pathology alone, in the absence of AD biomarker positivity, had less overall cognitive impairment but more focal dysexecutive and visuospatial deficits. +4 more findings

• Other Dementias

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Utilization Patterns and Clinical Factors Associated With Hospitalization in Early‐Stage Dementia With Lewy Bodies

44/100 ✓ Peer-reviewed Clinical safety International Journal of Geriatric Psychiatry

Key finding: Patients with DLB had significantly greater rates of hospitalization and ED visits compared to patients with AD (Incidence Rate Ratio (IRR): 1.46, 95% CI 1.24, 1.73, IRR: 1.46, 95% CI 1.29, 1.77, respectively) and controls (IRR: 1.77, 95% CI 1.46, 2.14, IRR: 2.21, 95% CI 1.82, 2.69, respectively) and ED visits compared to those with VD (IRR: 1.24, 95% CI 1.03, 1.50). +4 more findings

• Other Dementias
• Care Services

Full summary, score breakdown and related studies → Original source

Mechanisms of vitamin d deficiency as a risk factor for post-stroke depression, dementia, delirium, and fatigue: A promising therapeutic modality

29/100 ✓ Peer-reviewed Clinical safety Journal of Affective Disorders Reports

Key finding: Acute ischemic stroke often results in a multitude of neuropsychiatric complications, including depression, dementia, delirium, and fatigue. +2 more findings

• Treatments
• Risk Factors
• Lifestyle

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Occurrence, associated factors, and outcomes of delirium in patients in an adult acute general medicine service in England: a 10-year longitudinal, observational study

63/100 ✓ Peer-reviewed Clinical safety The Lancet Healthy Longevity

Key finding: In those aged 65 years or older, delirium was overall associated (all p<0·001, age and sex adjusted) with dementia ( adj OR 3·63 [95% CI 2·65–4·98]), pre-admission dependency (2·63 [2·02–3·43]), comorbidity burden (1·04 [1·02–1·05]), and frailty (moderate vs low risk 3·62 [2·70–4·85] and high vs low risk 11·85 [7·24–19·42]), with stronger associations in patients without comorbid dementia than in those with comorbid dementia. +3 more findings

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Medication Causes and Treatment of Delirium in Patients With and Without Dementia

54/100 ✓ Peer-reviewed Clinical safety Brain and Behavior

Key finding: Out of 3867 papers identified, 106 were included. +4 more findings

• Treatments

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Effect of combined transcranial direct current stimulation and cognitive training on brain microstructure and network homogeneity in late-life depression: a pilot study

39/100 ✓ Peer-reviewed Prevention trials Journal of Affective Disorders Reports

Key finding: Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity. +4 more findings

• Clinical Trials
• Lifestyle

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Mind your nose: A randomized controlled trial of olfactory‐based memory training for older people with subjective cognitive decline

41/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Consistent with previous research, transfer gains from the OMT condition to an untrained VM task suggest that olfaction may contribute to a‐modal representations of memory. +2 more findings

• Clinical Trials
• Early Stage

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Profiling complement dysregulation in frontotemporal dementia using cerebrospinal fluid, plasma, and exosomes

37/100 ✓ Peer-reviewed Disease mechanisms Immunobiology

Key finding: In plasma, most complement analytes were not significantly different between spFTD and HC; the exceptions were C4 and FB, significantly decreased in spFTD vs HC ( p = 0.0192 and p = 0.0181, respectively), suggesting complement consumption in classical and alternative pathways. +2 more findings

• Biomarkers

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C3 and C3a as indicators of complement dysregulation in tauopathies and FTLD-associated disorders

39/100 ✓ Peer-reviewed Disease mechanisms Immunobiology

Key finding: Compared to HC, C3, C3a and properdin were elevated in FTLD (p = 0.0002, p = 0.0187, p = 0.0451 respectively). +4 more findings

• Other Dementias
• Brain Biology

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Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G

41/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: All participants had heterozygous c.1184A > G, p.Asp395Gly in VCP. +4 more findings

• Brain Biology
• Brain Scans

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Paeoniflorin exercise-mimetic potential regulates the Nrf2/HO-1/BDNF/CREB and APP/BACE-1/NF-κB/MAPK signaling pathways to reduce cognitive impairments and neuroinflammation in amnesic mouse model

42/100 ✓ Peer-reviewed Inflammation and the immune system Biomedicine & Pharmacotherapy

Key finding: Microglia-mediated neuroinflammation plays a crucial role in memory and cognitive deficits and the development of early mild cognitive impairment (MCI) associated with Alzheimer's disease (AD). +2 more findings

• Brain Biology
• Digital Tools

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Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis

48/100 ✓ Peer-reviewed Inflammation and the immune system Nature Communications

Key finding: In the APPswe/PS1dE9 (APP/PS1) mouse model of amyloidosis, we demonstrated that microglial Cx43 hemichannels correlated with microglial malfunction, which in turn exacerbated β-amyloid pathology.

• Brain Biology

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Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study

61/100 ✓ Peer-reviewed Brain tissue and pathology EBioMedicine

Key finding: Longitudinal analysis identified significant associations between the change in ether lipid species (including alkylphosphatidylcholine, alkenylphosphatidylcholine, lysoalkylphosphatidylcholine, and lysoalkenylphosphatidylcholine) and AD dementia conversion. +4 more findings

Full summary, score breakdown and related studies → Original source