Newest studies

A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

57/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: ApoE4 levels ascertained by the e4Quant test exhibited clear genotype-dependent stratification. +1 more finding

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

White matter hyperintensities contribute to early cortical thinning in addition to tau in aging

45/100 ✓ Peer-reviewed Vascular contributions Neurobiology of Aging

Key finding: White matter hyperintensities (WMH) are associated with cortical thinning in distant brain regions. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

No robust add-on effects of prefrontal theta–gamma tACS to cognitive training on episodic memory in non-demented older adults

38/100 ✓ Peer-reviewed Prevention trials Clinical Neurophysiology

Key finding: The primary analysis demonstrated significant improvements in multiple episodic memory measures across both intervention groups, with no significant differences observed between groups. +4 more findings

Full summary, score breakdown and related studies → Original source

The differential effect of strength, cognitive and aerobic training combinations on cognitive performance and functional abilities in elderly with cognitive decline: The Fit4Alz project

56/100 ✓ Peer-reviewed Prevention trials The Journal of Prevention of Alzheimer s Disease

Key finding: After the intervention, the CG showed significantly lower scores compared to all experimental groups. +3 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

45/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroinflammation

Key finding: In this study, we show that repeated ethanol binges aggravate the amyloid pathology and plaque burden in the hippocampus of APP/PS1 mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

TDP-43 proteinopathy: the complex biological and clinical findings in LATE-NC, LANS, and other mixed age-related major neurocognitive disorders

32/100 ✓ Peer-reviewed Brain tissue and pathology Current Opinion in Psychiatry

Key finding: Since the term limbic-predominant age-related TDP-43 encephalopathy (LATE) was coined in 2019, more than 200 articles addressing the subject were published.

• Brain Biology
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment among older adults in outpatient clinics: Awareness and knowledge needs survey

32/100 ✓ Peer-reviewed Mild cognitive impairment Experimental Gerontology

Key finding: The MCI symptom awareness score among older adults in outpatient clinics was 7.45 ± 3.58 points. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases

63/100 ✓ Peer-reviewed Lewy body dementia Nature Medicine

Key finding: Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD), exhibit distinct yet overlapping pathological mechanisms. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity

63/100 ✓ Peer-reviewed Risk factors JAMA Network Open

Key finding: A total of 60 860 adults with type 2 diabetes and obesity were included, with 30 430 each in the GLP-1RA group (mean [SD] age, 57.9 [9.9] years; 50.2% female) and the other antidiabetic drug group (mean [SD] age, 58.0 [10.8] years; 51.4% female) after propensity score matching. +4 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Multimodal Detection of Agitation in People With Dementia in Clinical Settings: Observational Pilot Study

41/100 ✓ Peer-reviewed Digital health tools JMIR Aging

Key finding: The Extra Trees model achieved up to 99% accuracy for personalized wristband data, while the multilayer perceptron model performed best in general models with 98% accuracy. +4 more findings

Full summary, score breakdown and related studies → Original source

An explainable and efficient deep learning framework for EEG-based diagnosis of Alzheimer's disease and frontotemporal dementia

47/100 ✓ Peer-reviewed Digital health tools Frontiers in Medicine

Key finding: The early and accurate diagnosis of Alzheimer's Disease and Frontotemporal Dementia remains a critical challenge, particularly with traditional machine learning models which often fail to provide transparency in their predictions, reducing user confidence and treatment effectiveness. +4 more findings

• Digital Tools
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Associations of cardiovascular health assessed by life’s crucial 9 with incident cardiovascular disease and dementia: A prospective cohort study

46/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: Of 289,649 included participants, 137,480 (47.5 %) were male, and the mean age was 56.6 ± 8.1 years. +4 more findings

Full summary, score breakdown and related studies → Original source

The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia

53/100 ✓ Peer-reviewed Getting a diagnosis Journal of the Neurological Sciences

Key finding: The advent of highly sensitive single-molecule array (Simoa®) assays has significantly enhanced the accuracy of blood-based biomarker quantification, including glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181). +2 more findings

• Biomarkers
• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Comment by European Alzheimer’s Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer’ s disease

36/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease

• Treatments

Full summary, score breakdown and related studies → Original source

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases

58/100 ✓ Peer-reviewed Digital health tools Nature medicine

Key finding: Analysis of the dorsolateral prefrontal cortex proteome for 262 donors from the Accelerating Medicines Partnership for AD UPenn Proteomics Study revealed a consistent APOE ε4 phenotype, independent of neurodegenerative pathology, including amyloid-β tau and gliosis for all diseases, as well as TDP-43 in ALS and FTD cases, and α-synuclein in PD and PDD cases. +2 more findings

• Genetics
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study)

64/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: After 12 months, no statistically significant difference was observed between MLI+EGCG and MLI+placebo in the PACC-exe (adjusted mean difference [AMD]: 0.12; 95%CI: -0.01, 0.24; p=0.061). +3 more findings

• Clinical Trials
• Lifestyle
• Early Stage

Full summary, score breakdown and related studies → Original source

Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: 363 participants across three cohorts, including familial (PSEN1 mutation) and general community cohorts +3 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Differential effects of a multidomain intervention on cognitive decline in older adults with type 2 diabetes according to white matter hyperintensity status: A secondary analysis of the J‐ MIND ‐Diabetes

47/100 ✓ Peer-reviewed Prevention trials Diabetes Obesity and Metabolism

Key finding: Among 90 participants included in the analyses, 34 had moderate to severe WMH. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Pathological mechanisms and treatment progression of Alzheimer’s disease

47/100 ✓ Peer-reviewed Disease mechanisms European journal of medical research

Key finding: Current therapeutic approaches, including recently approved anti-amyloid immunotherapies, demonstrate limited clinical efficacy and significant adverse effects, highlighting the need for alternative treatment strategies.

• Treatments
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia

48/100 ✓ Peer-reviewed Risk factors Scientific data

Key finding: Alzheimer's disease and related dementia (ADRD) are becoming increasingly prevalent and are predicted to affect up to 153 million globally by 2050. +4 more findings

Full summary, score breakdown and related studies → Original source

End-of-life care in hospitalized patients with dementia

49/100 ✓ Peer-reviewed End-of-life care The Journals of Gerontology Series A

Key finding: The study cohort comprised patients with a mean age of 87.2 ± 7.2 years (n = 100), 63% of whom had lived in nursing homes. +3 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Mediterranean diet score linked to cognitive functioning in Czech women: a cross-sectional population-based study

46/100 ✓ Peer-reviewed Prevention trials European Journal of Nutrition

Key finding: There were no significant associations in men. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Challenges and needs in dementia care: people with dementia and family caregivers’ experiences from diagnosis to follow-up in Swedish primary care: a qualitative study

33/100 ✓ Peer-reviewed Caregiving Scandinavian Journal of Primary Health Care

Key finding: This study explores how older people with dementia and their family caregivers experience the process from diagnosis to follow-up in primary care, what support is needed, what works well and what could be improved. +1 more finding

• Caregiving
• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease

43/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s Research & Therapy

Key finding: We included 71 DLB (76.8 ± 7.4 years old, 25 females) and 71 age- and sex-matched AD patients (and 75.2 ± 5.3 years old, 27 females). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Emerging biomarkers and frontier therapies: unveiling the role of endothelial dysfunction in cerebral small vessel disease

39/100 ✓ Peer-reviewed Vascular contributions Frontiers in Neurology

Key finding: Cerebral small vessel disease (cSVD), a major contributor to stroke, cognitive decline, and vascular dementia, accounts for around 25% of ischemic strokes and significantly impacts age-related neurological disability.

• Other Dementias

Full summary, score breakdown and related studies → Original source