Newest studies

Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study

50/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Neighborhood disadvantage was associated with worse cognitive performance on memory, executive function, processing speed, and preclinical Alzheimer's tests on both datasets. +4 more findings

• Health Equity

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Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: As Alzheimer disease is the third leading cause of death and a significant factor in end-of-life complications for adults with Down syndrome, identifying interventions is a medical necessity. +1 more finding

• Down Syndrome
• Treatments
• Prevention

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Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries

49/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma phosphorylated threonine 181 of tau (pTau181) and amyloid beta (Aβ) are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). +1 more finding

• Biomarkers
• Genetics

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Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort

53/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Amyloid burden is an important prognostic marker in a clinically heterogeneous cohort. +4 more findings

• Brain Scans
• Early Stage

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Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Plasma p-tau217/Aβ42 has high performance in detecting cerebral AD pathologies, thus offering a promising tool for clinical diagnosis and community screening of AD.

• Biomarkers
• Diagnosis

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Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification

65/100 ✓ Peer-reviewed Genetics Alzheimer's & Dementia

Key finding: Alongside APOE ε4, iPRS-DEM may refine risk stratification for the enrichment of dementia clinical trials and prevention programs. +2 more findings

• Genetics
• Risk Factors

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Advance care planning for older adults with advanced dementia living at old age homes- perspective of the surrogates

31/100 ✓ Peer-reviewed End-of-life care Archives of Gerontology and Geriatrics Plus

Key finding: An overarching thematic arrangement of the process for ACP decision-making by surrogates of PWAD includes seven emerged themes: (1) Pragmatic arrangement, (2) Timing of ACP, (3) Meaning of suffering, (4) Emotional stress, (5) Family support, (6) ACP barriers and (7) Decision-making. +4 more findings

• End-of-Life Care

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Assessing cognitive impairment in HIV-infected: a comparative study of international HIV Dementia Scale, HIV Dementia Scale Italian version and Montreal cognitive assessment in clinical practice

44/100 ✓ Peer-reviewed Getting a diagnosis Journal of NeuroVirology

Key finding: The combination of antiretroviral therapy (cART) and preventive measures has significantly enhanced the management of Human Immunodeficiency Virus (HIV) infection. +4 more findings

• Diagnosis

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Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review

62/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Evidence suggests that vegan and vegetarian diets, when well planned, can be rich in phytonutrients and antioxidants, which have been associated with lower levels of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6). +4 more findings

• Lifestyle

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Current amyloid inhibitors: Therapeutic applications and nanomaterial-based innovations

40/100 ✓ Peer-reviewed Treatments Progress in Neurobiology

Key finding: Amyloid proteins have long been in the spotlight for being involved in many degenerative diseases including Alzheimer´s, Parkinson´s or type 2 diabetes, which currently cannot be prevented and for which there is no effective treatment or cure. +4 more findings

• Treatments

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Combination of Aβ40, Aβ42, and Tau Plasma Levels to Distinguish Amyloid-PET Positive Alzheimer Patients from Normal Controls

39/100 ✓ Peer-reviewed Biomarkers Experimental Neurobiology

Key finding: In this study, we found that a composite of standard factors, Aβ40 and total tau levels in plasma, divided by the variation factor, plasma Aβ42 level, provide better correlation with amyloid neuroimaging and neuropsychological test results than a level comparison between total tau and Aβ42 in plasma. +2 more findings

• Biomarkers
• Brain Scans
• Brain Biology

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The historical and projected prevalence of dysphagia in Aotearoa New Zealand

33/100 ✓ Peer-reviewed Clinical safety New Zealand Medical Journal

Key finding: The prevalence of dysphagia in Aotearoa New Zealand is estimated to have been approximately 1.78% in 2020, with the biggest aetiological contributors being stroke, Alzheimer's disease and other dementias, and gastroesophageal reflux disease. +4 more findings

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Unravelling Shared Pathways Linking Metabolic Syndrome, Mild Cognitive Impairment, Dementia, and Sarcopenia

43/100 ✓ Peer-reviewed Disease mechanisms Metabolites

Key finding: Metabolic syndrome markers, such as insulin resistance and the triglyceride/HDL C ratio, correlate with early cognitive impairment. +4 more findings

• Brain Biology
• Treatments

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Age-Related Cognitive Decline and Dementia: Interface of Microbiome–Immune–Neuronal Interactions

45/100 ✓ Peer-reviewed Inflammation and the immune system The Journals of Gerontology Series A

Key finding: This review presents evidence about the types of microbiome alterations associated with healthy versus unhealthy aging and how they interact with immune cells linked to neuronal and cognitive functions.

• Brain Biology

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Brain age mediates gut microbiome dysbiosis-related cognition in older adults

47/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: Two clusters were identified in the microbiota at the phylum level that showed significant differences on a few microbiotas phylum. +3 more findings

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Prevalence, deaths and disability-adjusted life years due to Alzheimer’s disease and other dementias in Middle East and North Africa, 1990–2021

49/100 ✓ Peer-reviewed How common it is Scientific Reports

Key finding: This rate decreased by 4.9% in comparison to 1990, marking a statistically significant change. +4 more findings

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Postural Sway Characteristics Distinguish Types of Dementia

61/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Medical Directors Association

Key finding: The data of 1734 participants (1158 with AD, 105 with DLB, 46 with VaD, and 425 with CN) were analyzed. +3 more findings

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Weighted Blankets for Agitation in Hospitalized Patients with Dementia: Protocol for a Randomized Controlled Trial

36/100 ✓ Peer-reviewed Clinical safety JMIR Research Protocols

Key finding: Enrollment of participants began on April 23, 2023. +4 more findings

• Clinical Trials
• Care Services

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Myopathic aggregation-prone variants in the TDP-43 prion-like domain: genetics paving the way

41/100 ✓ Peer-reviewed Brain tissue and pathology Brain

Key finding: In addition, TAR DNA-binding protein-43 (TDP-43) has been reported to be essential in normal muscle physiology as it is implicated in the formation of so-called amyloid-like myogranules during normal muscle regeneration after injury. +4 more findings

• Brain Biology
• Genetics

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Quality of Life of Older Adults Living With Dementia and Caregiver Strain in Benin

44/100 ✓ Peer-reviewed Caregiving Value in Health Regional Issues

Key finding: A total of 114 older adults (mean age 73 ± 10 years, 51% female) and their primary caregivers (mean age 49 ± 16 years, 70% female) participated, of whom 73 were recruited from health facilities and 41 from rural communities. +4 more findings

• Caregiving

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The evolution of serious health-related suffering from 1990 to 2021: an update to The Lancet Commission on global access to palliative care and pain relief

57/100 ✓ Peer-reviewed Caregiving The Lancet Global Health

Key finding: The SHS global burden increased by 74% between 1990 and 2021 to almost 73·5 million individuals, with population growth accounting for only half of that increase. +4 more findings

• End-of-Life Care

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Relationship between anxiety and fatigue in dementia family caregivers: hope as a mediator

43/100 ✓ Peer-reviewed Caregiving BMC Nursing

Key finding: The findings revealed a significant negative correlation between fatigue and hope (r = -.431, p <.01), a significant positive correlation between fatigue and anxiety (r =.584, p <.01), and a significant negative correlation between hope and anxiety (r = -.364, p <.01). +3 more findings

• Caregiving

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Caring for an older person with dementia: Behavioral problems in the eyes of family caregivers and migrant home care workers

36/100 ✓ Peer-reviewed Caregiving Dementia

Key finding: The first theme concerned the main challenges associated with caring for a person with dementia. +1 more finding

• Caregiving
• Care Services

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Race and Ethnicity, Lifestyle, Diet, and Survival in Patients With Prostate Cancer

62/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: A total of 2603 men with nonmetastatic PCa (mean [SD] age, 69.6 [7.1] years) were followed up, and 1346 deaths were documented, including 356 (24.6%) from CVD and 197 (14.6%) from PCa. +4 more findings

• Lifestyle
• Health Equity
• Prevention

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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer’s disease

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

Key finding: We find wide dysregulation of the proteome, beyond proteins encoded by chromosome 21, including an increase in the abundance of the key AD-associated protein, APOE, in people with DSAD compared to matched cases of AD. +2 more findings

• Down Syndrome
• Genetics

Full summary, score breakdown and related studies → Original source