Newest studies

The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

48/100 ✓ Peer-reviewed Prevention trials JMIR Research Protocols

Key finding: This work was supported by a Crossover grant (Maintaining Optimal Cognitive Functioning In Aging [MOCIA] 17611) of the Dutch Research Council (NWO), granted in December 2019. +4 more findings

• Clinical Trials
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Curcumin-Rich Curry Consumption Is Associated with Lower Risk of Cognitive Decline and Incidence of Mild Cognitive Impairment or Dementia: An Asian Population-Based Study

56/100 ✓ Peer-reviewed Cognitive tests and assessment Nutrients

Key finding: A decreasing linear trend was observed between higher levels of curry consumption and cognitive decline (p = 0.037). +3 more findings

• Risk Factors
• Early Stage

Full summary, score breakdown and related studies → Original source

Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease

45/100 ✓ Peer-reviewed Risk genes beyond APOE Science Translational Medicine

Key finding: Using spatial transcriptomics on the human brain, we observed that the SEMA6D-TREM2 cross-talk gene network is activated near Aβ plaques and SEMA6D-expressing cells. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Addressing Caregivers’ Needs beyond Respite: Enhancing Social Connections and Letting Them Know They Matter

34/100 ✓ Peer-reviewed Caregiving Canadian Journal on Aging / La Revue canadienne du vieillissement

Key finding: As a result, caregivers tend to experience a decline in well-being, due, in part, to a reduction in meaningful leisure experiences. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Structural MRI–based Computer-aided Diagnosis Models for Alzheimer Disease: Insights into Misclassifications and Diagnostic Limitations

38/100 ✓ Peer-reviewed Brain scans and imaging Radiology Artificial Intelligence

Key finding: The 3D Nested Hierarchical Transformer model helped to accurately diagnose Alzheimer disease based on structural brain MRI scans. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial

47/100 ✓ Peer-reviewed Getting a diagnosis Journal of Medical Internet Research

Key finding: The ACoE's overall cognitive assessments were significantly reliable (ICC [intraclass correlation coefficient]=0.89; P<.001). +4 more findings

• Diagnosis
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Optimal cut-off scores for the Mini Mental State Examination and Montreal Cognitive Assessment to detect MCI and dementia in Multiple System Atrophy

39/100 ✓ Peer-reviewed Getting a diagnosis Parkinsonism & Related Disorders

Key finding: According to the II level neuropsychological evaluation, 4.8 % of MSA patients met criteria for dementia and 53,2 % for MCI. +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies

48/100 ✓ Peer-reviewed Prevention and risk International Journal of Molecular Sciences

Key finding: Emerging evidence highlights the significant role of maternal conditions such as obesity, comorbidities, nutrition, and environmental exposures in predisposing offspring to long-term metabolic and cardiovascular diseases.

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Artificial Intelligence–Assisted Detection of Amyloid-Related Imaging Abnormalities: Promise and Pitfalls

42/100 ✓ Peer-reviewed Treatments American Journal of Neuroradiology

Key finding: The advent of anti-amyloid therapies (AATs) for Alzheimer disease (AD) has elevated the importance of MRI surveillance for amyloid-related imaging abnormalities (ARIA) such as microhemorrhages and siderosis (ARIA-H) and edema (ARIA-E). +4 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

43/100 ✓ Peer-reviewed Disease mechanisms Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Key finding: Here, it is demonstrated that SENP6 knockdown-induced SUMOylation causes loss of mitochondrial proteostasis, which impairs mitochondrial morphology and function. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics

43/100 ✓ Peer-reviewed Drug development Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Key finding: These agents, whose receptors are widely expressed in brain regions involved in cognition and metabolism, modulate neurotransmitter release and promote neurogenesis. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Unveiling 30 years of research on speech biomarker of dementia using text mining

59/100 ✓ Peer-reviewed Cognitive tests and assessment Digital health

Key finding: Our analysis yielded three major a marked acceleration in research activity since 2020, a convergence of clinical needs with technological advancements, and the inherently interdisciplinary nature of this field. +2 more findings

Full summary, score breakdown and related studies → Original source

Prevalent Cardiovascular Disease and Atrial Fibrillation in Relation to Cerebral Small Vessel Disease Burden

48/100 ✓ Peer-reviewed Vascular contributions Brain Sciences

Key finding: In 3413 participants (mean age: 59 ± 14 years, 53.4% women), 11% had prevalent CVD or AF, 8% had prevalent CVD, and 4% had prevalent AF. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Delirium education priorities for healthcare professional students: a modified Delphi study

37/100 ✓ Peer-reviewed Clinical safety BMC Medical Education

Key finding: Eighty participants completed round one of the Delphi survey and 55 (68.75%) also completed round two. +4 more findings

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid β‐Amyloid and τ Levels in Patients With Iatrogenic Cerebral Amyloid Angiopathy, Sporadic Cerebral Amyloid Angiopathy, Alzheimer Disease, and Controls

49/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the American Heart Association

Key finding: The study included 25 patients with iCAA (age, 44±11 years), 31 patients with sCAA (age, 75±5 years), 28 patients with AD (age, 71±8 years) and 30 controls (age, 72±8 years) from 9 case descriptions and 1 cohort study. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease

45/100 ✓ Peer-reviewed Brain scans and imaging The Journal of Prevention of Alzheimer s Disease

Key finding: Progressive cortical thinning in multiple cognition-related regions was significantly associated with cBF atrophy. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes

40/100 ✓ Peer-reviewed Biomarkers Cells

Key finding: Neuro-Cells (NC), a combination of unmodified mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), have demonstrated therapeutic potential in models of central nervous system (CNS) injury and neurodegeneration.

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Cost-Effective Price of Lecanemab for Patients with Early Alzheimer's Disease in Sweden

48/100 ✓ Peer-reviewed Costs and economics PharmacoEconomics

Key finding: The future price of lecanemab in European countries is unknown. +1 more finding

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Alzheimer's Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer's disease within specialized care settings

73/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

Key finding: The panel cautions users of this guideline that there is significant variability in diagnostic test accuracy and many commercially available BBM tests do not meet these thresholds, especially using a single cutoff.

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Human brain vascular multi-omics elucidates disease-risk associations

43/100 ✓ Peer-reviewed Genetics Neuron

Key finding: We found cerebrovascular and neurodegenerative disease variants have distinct mechanisms: cerebrovascular disease variants disrupt extracellular matrix genes in endothelial, mural, and fibroblast cells important for vessel structural integrity, while Alzheimer's disease (AD) variants dysregulate inflammatory adaptor proteins in endothelial and immune cells.

• Genetics

Full summary, score breakdown and related studies → Original source

A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024

52/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

Key finding: This bibliometric analysis provides a comprehensive overview of research trends in immune-related cognitive impairment. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Beneficial Effects of Water-Based Exercise Alone and in Combination with Cognitive Training on Cardiovascular Fitness and Arterial Stiffness in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial

33/100 ✓ Peer-reviewed Prevention trials Life

Key finding: Mild cognitive impairment (MCI) is the transitional stage between normal cognition and dementia and is associated with arterial stiffness, which may lead to cardiovascular disease. +3 more findings

• Lifestyle
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Early Dysregulation of RNA Splicing and Translation Processes Are Key Markers from Mild Cognitive Impairment to Alzheimer’s Disease: An In Silico Transcriptomic Analysis

36/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: In this article, we retrieved data from the online available dataset GSE63060, which includes transcriptomic data of 329 blood samples, of which there are 104 cognitively normal controls, 80 MCI patients, and 145 AD patients. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression

48/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: Receiver operating characteristic (ROC) analysis identified right hippocampal MD and t-tau as optimal classifiers for AD. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Application of machine learning in EEG-based dementia diagnosis: Classification and differential diagnosis

43/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer s Disease

Key finding: BackgroundElectroencephalogram (EEG) is a promising, non-invasive method for identifying the presence of Alzheimer's disease (AD) by recognizing specific brain activity patterns associated with the disease. +2 more findings

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source