Newest studies

Hospitalization risk with and without dementia by region and race in the United States

40/100 ✓ Peer-reviewed Risk factors American Journal of Epidemiology

Key finding: Black relative risk was significantly higher than White relative risk in 90.2% (2740/3037) of counties for hospitalization with ADRD and 44.7% (1359/3037) of counties for hospitalization without ADRD. +1 more finding

• Care Services

Full summary, score breakdown and related studies → Original source

Semaglutide for obesity management: A narrative review of efficacy, safety, and future directions

35/100 ✓ Peer-reviewed Drug development Journal of the American Pharmacists Association : JAPhA

Key finding: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), particularly semaglutide, have demonstrated substantial efficacy for glycemic control and weight management and are increasingly prescribed across diverse populations. +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions

39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Antioxidants (Basel, Switzerland)

Key finding: Down syndrome (DS), caused by trisomy 21, is the most prevalent genetic condition associated with accelerated aging and near-universal development of early-onset Alzheimer's disease (AD).

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Impact of Different Antihypertensive Drug Classes on Incident Dementia in Older Adults: A Systematic Review and Meta-Analysis

58/100 ✓ Peer-reviewed Prevention and risk Journal of the American Medical Directors Association

Key finding: Antihypertensive treatment significantly improved cognitive function scores (SMD, 0.06; 95% CI, 0.03-0.09; P Conclusions and implications Antihypertensive therapy significantly improves cognitive function with moderate certainty evidence, supporting its use for cognitive protection in older adults with hypertension. +1 more finding

• Treatments
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Amyloid-Related Imaging Abnormalities (ARIA) in Anti-Amyloid Therapies for Alzheimer's Disease: An Update from the Alzheimer's Association ARIA Workgroup

69/100 ✓ Peer-reviewed Treatments Alzheimer's & Dementia

Key finding: ARIA-E/ARIA-H rates: ~12.6%/17.3% with lecanemab, ~24%/31% with donanemab in pivotal trials +2 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Age-stratified associations between severe mental illness, dementia, and ischemic stroke: findings from the PADRIS-PRESTO cohort

57/100 ✓ Peer-reviewed Vascular contributions European Neuropsychopharmacology

Key finding: Adults with a lifetime SMI diagnosis were compared with controls without any psychiatric condition. +2 more findings

Full summary, score breakdown and related studies → Original source

Connecting HTT intermediate alleles and microRNA dysregulation to enhanced tauopathy in late-onset Alzheimer’s disease

34/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s Research & Therapy

Key finding: HTT IAs carriers patients exhibited decreased survival after disease onset compared to non-carriers. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Advanced Glycation End Products Induce Microglial Activation and Impair Neurodevelopment in Human iPSC-Derived Brain Organoids

28/100 ✓ Peer-reviewed Disease mechanisms Organoids

Key finding: Our findings reveal that AGEs induce RAGE expression, leading to microglial activation, increased deposition of amyloid-beta (Aβ) aggregates, and impaired neurodevelopment. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-β, Tau Protein, α-Synuclein, TDP-43, and FUS in Mixed Pathology: And Intrinsic Disorder to Rule Them All

47/100 ✓ Peer-reviewed Brain tissue and pathology International Journal of Molecular Sciences

Key finding: Neurodegenerative diseases, including Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Disease (LBD), and related dementias, represent a global health challenge, particularly in aging populations. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Assisted Living Staff Perspectives on End-Of-Life Care for Residents Living With Dementia: A Qualitative Study

31/100 ✓ Peer-reviewed End-of-life care American Journal of Hospice and Palliative Medicine®

Key finding: As part of the training, staff completed two homework assignments: (1) defining what constitutes a good death for residents with dementia, and (2) identifying one resident and at least one action to address EOL care needs. +4 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Loneliness as a Pathway Linking Hearing Decline to Cognitive Aging: Longitudinal and Genetic Evidence

72/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In longitudinal parallel-process latent growth curve models ( N = 10,375) using nine waves of longitudinal data from the Survey of Health, Ageing and Retirement in Europe (SHARE), poorer hearing was associated with greater loneliness, and greater loneliness was associated with poorer cognitive performance, consistent with partial mediation. +3 more findings

• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

The Genetics and Mechanisms of Alzheimer's Disease in Down Syndrome

26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Mental Health Disorders

Key finding: Experimental and preliminary clinical evidence suggests that restoration of physiological GnRH signaling may improve cognition and functional brain connectivity in adults with DS.

• Down Syndrome
• Genetics

Full summary, score breakdown and related studies → Original source

Use of Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinson's Disease: Scandinavian Cohort Study

73/100 ✓ Peer-reviewed Drug development Diabetes, obesity & metabolism

Key finding: Mean age was 65 years and 43% were female. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

59/100 ✓ Peer-reviewed Disease mechanisms Nature Communications

Key finding: Voxel-wise analyses revealed widespread loss of deactivation and activation with disease progression. +2 more findings

Full summary, score breakdown and related studies → Original source

The In Vitro Multifaceted Biological Activity of Catechins in Relation to Their Oxidation Potentials

37/100 ✓ Peer-reviewed Disease mechanisms Molecules

Key finding: The provided results expand our knowledge on the multifaceted activity of catechins, indicating EGCG and ECG as the most active antioxidants against inhibition of ACE and AChE as well as towards AGE formation.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer’s disease: Pathophysiology, current and emerging therapeutic approaches for Alzheimer’s disease

27/100 ✓ Peer-reviewed Treatments Current Trends in Pharmacy and Pharmaceutical Chemistry

Key finding: Emerging approaches include anti-amyloid antibodies, BACE1, gamma-secretases, anti-tau therapies, stem cell, and gene therapies. +4 more findings

• Treatments
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Anemia and Blood Biomarkers of Alzheimer Disease in Dementia Development

64/100 ✓ Peer-reviewed Biomarkers JAMA Network Open

Key finding: A total of 3363 adults were enrolled in SNAC-K (73.3% participation rate). +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cardiovascular Health at Midlife and Alzheimer Disease Biomarkers

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: We investigated whether vascular and lifestyle factors are associated with AD plasma and imaging biomarkers in midlife. +3 more findings

• Biomarkers
• Risk Factors

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 25

32/100 ✓ Peer-reviewed Health systems and care delivery Journal of comparative effectiveness research

Key finding: In this update, we discuss the use of real-world data in the Haute Autorité de Santé assessment of economic evaluations, review how real-world evidence is supporting regulatory approvals in multiple myeloma, and consider lessons from the failed EVOKE trials of semaglutide in Alzheimer's disease for the broader application of target trial emulation.

• Policy

Full summary, score breakdown and related studies → Original source

Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia

60/100 ✓ Peer-reviewed Vascular contributions JAMA Network Open

Key finding: A total of 42 342 participants from the pooled cohorts were included (mean [SD] age, 61.3 [9.8] years; 55.0% female). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition

53/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: A total of 261 patients (75.3±6.8 years) were recruited from a memory-clinic cohort. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic

57/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD. +3 more findings

• Brain Biology
• Care Services

Full summary, score breakdown and related studies → Original source

Toward precision risk stratification of postoperative cognitive dysfunction: Preoperative inflammatory and neurodegenerative protein biomarkers in orthopedic surgery: A systematic review

49/100 ✓ Peer-reviewed Tau biomarkers Journal of clinical anesthesia

Key finding: Postoperative Cognitive Dysfunction (POCD) is a common complication in older adults undergoing major surgery and is associated with prolonged recovery and long-term cognitive decline. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer's disease (Cochrane review)

76/100 ✓ Peer-reviewed Treatments Cochrane Database of Systematic Reviews

Key finding: Synthesis methods We meta-analysed results for each outcome within each comparison using the inverse variance method and the random-effects model. +4 more findings

• Treatments
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lecanemab appropriate use recommendations for clinical practice in the UK

45/100 ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry

Key finding: Lecanemab is an anti-amyloid monoclonal antibody, recently approved in the UK as a treatment for mild cognitive impairment (MCI) and mild dementia due to Alzheimer's disease (AD) in adults who are apolipoprotein E ε4 gene (APOE4) heterozygotes or non-carriers.A group of UK neurologists, old age psychiatrists and geriatricians with expertise in AD convened to agree appropriate use recommendations for lecanemab in UK clinical practice. +4 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source