Newest studies

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

72/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: These findings suggest that the plasma Aβ42/Aβ40 may be useful in identifying individuals with very low levels of amyloid pathology, whereas p-tau, GFAP, and NfL may be useful in staging disease progression. +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model

36/100 ✓ Peer-reviewed Disease mechanisms Aging Cell

Key finding: Aging is the greatest risk factor for learning and memory disorders; dementia prevalence significantly increases with age due to numerous molecular changes in the body. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy

46/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Pharmacology and Experimental Therapeutics

Key finding: Emerging evidence suggests that addressing Aβ pathology during the earliest phases of AD, before the occurrence of neuronal damage, may be beneficial for preserving cognitive function.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

62/100 ✓ Peer-reviewed Risk factors New England Journal of Medicine

Key finding: A total of 14 participants (2 in part A and 12 in parts B and C) completed at least 12 months of follow-up and were included in the analyses. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Trends, inequalities, and cross-location similarities in global dementia burden and attributable risk factors across 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

43/100 ✓ Peer-reviewed Disparities International Journal of Surgery

Key finding: In 2021, dementia accounted for 56.9 million global cases, 2.0 million deaths, and 36.3 million DALYs. +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

In-home respite care in dementia: An evolutionary concept analysis

34/100 ✓ Peer-reviewed Caregiving International Journal of Nursing Sciences

Key finding: This conceptual analysis revealed the evolution of in-home respite care service content over time and summarized three key attributes. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Decoding the Clinical Features that Associate with Progression, Causes, and Outcomes in Patients with Suspected Rapidly Progressive Dementia

52/100 ✓ Peer-reviewed Getting a diagnosis Annals of Neurology

Key finding: Selected clinical features may identify patients with suspected RPD who are likely to continue to decline. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease

35/100 ✓ Peer-reviewed Treatments Neurology Clinical Practice

Key finding: ε4 heterozygous woman with mild cognitive impairment and CSF biomarker evidence of AD underwent treatment with intravenous lecanemab. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer's disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: KChIP3 levels were significantly elevated in the hippocampus of 5XFAD mice, correlating with βA burden and neuroinflammation. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer Disease

43/100 ✓ Peer-reviewed TREM2 and immune genetics The American journal of pathology

Key finding: Alzheimer disease (AD) is a chronic, multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease

38/100 ✓ Peer-reviewed Inflammation and the immune system Neural Regeneration Research

Key finding: Our results showed that chronic administration of MCC950 (10 mg/kg) to spontaneously hypertensive rats inhibited NOD-like receptor family pyrin domain-containing protein 3 inflammasome activation, thereby considerably suppressing the production of pyroptosis executive protein gasdermin D and pro-inflammatory factors, including interleukin-1β and -18. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers

43/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging

Key finding: A total of 1,223 articles were identified. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Understanding Digital Literacy of Persons With Dementia and Their Caregivers: A Scoping Review and an Evolutionary Concept Analysis of Empirical Studies

42/100 ✓ Peer-reviewed Caregiving Journal of Applied Gerontology

Key finding: Our analysis revealed three antecedents of digital literacy: technology-enhanced support systems, individual characteristics, and sociodemographic characteristics, which collectively impact persons with dementia and their caregivers' abilities to utilize digital resources effectively. +3 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Transfer deep learning and explainable AI framework for brain tumor and Alzheimer's detection across multiple datasets

41/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in Medicine

Key finding: The model achieves accuracy rates of 94% on the brain tumor dataset, 81% on the augmented Alzheimer dataset, and 93% on the third dataset, underscoring its capability to differentiate various neurological conditions. +2 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum

50/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: We use diffusion MRI tractography to analyze SWM fiber clusters and assess their microstructure through free-water modeling, identifying significant differences between pathologically staged groups. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study

41/100 ✓ Peer-reviewed Getting a diagnosis Journal of Medical Internet Research

Key finding: RoCA classifies patients similarly to gold standard paper-based tests, with a receiver operating characteristic area under the curve of 0.81 (95% CI 0.67-0.91; P<.001). +4 more findings

• Diagnosis
• Clinical Trials
• Digital Tools

Full summary, score breakdown and related studies → Original source

Climate adaptation finance: From paper commitments to climate risk reduction

46/100 ✓ Peer-reviewed Prevention and risk Science

Key finding: Science can help to target climate finance at better-quality adaptation.

• Prevention

Full summary, score breakdown and related studies → Original source

Análisis comparativo del efecto de las dietas mediterránea, cetogénica, DASH y MIND en la prevención del alzheimer

44/100 ✓ Peer-reviewed Treatments MLS Health & Nutrition Research

Key finding: However, when selecting the most effective diet in Alzheimer's prevention, it is necessary to consider different types of nutritional approaches such as engaging in physical activity to improve cognitive decline.

• Lifestyle

Full summary, score breakdown and related studies → Original source

A High-Throughput Drug Screening Assay for Anti-Tau Aggregation Using Split GFP and Flow Cytometry

40/100 ✓ Peer-reviewed Drug development Scientific reports

Key finding: Our system employs suspension-adapted HEK293 cells co-transfected with tau proteins fused to complementary GFP fragments, producing fluorescent signals upon tau aggregation. +4 more findings

• Treatments
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Identifying and Predicting Cognitive Decline Using Multi-Modal Sensor Data and Machine Learning Approach

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research square

Key finding: Our results demonstrate that the multi-modal classifier achieved strong classification performance (accuracy = 68.64%; precision = 73.97%; F1-score=74.48%), with the highest recall (76.39%) from a model incorporating demographics and driving features, and prediction performance (accuracy = 70.48%; precision = 71.88%; F1-score = 74.80%, recall = 77.97%).

• Digital Tools

Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis

57/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: We recruited 210 participants; 205 (66.8% male; aged 66.4±11.1 years) had useable data. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Sweetened Beverages and Incident All-Cause Dementia Among Older Adults

56/100 ✓ Peer-reviewed Brain tissue and pathology JAMA Psychiatry

Key finding: Of 10 974 participants (60.0% female, mean [SD] age: 73.2 [6.8] years), 2445 developed incident all-cause dementia over 116 067 person-years of follow-up. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Perspectives and Experiences of Family Caregivers Using Supportive Mobile Apps in Dementia Care: Meta-Synthesis of Qualitative Research

44/100 ✓ Peer-reviewed Caregiving JMIR mhealth and uhealth

Key finding: A preliminary search yielded 4772 studies, of which 12 (0.25%) met the criteria. +4 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

61/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms and awareness in young-and-late-onset dementia

31/100 ✓ Peer-reviewed Brain tissue and pathology Aging & Mental Health

Key finding: The YOD group was more cognitively compromised, more anxious, and presented more aberrant motor behaviors than the LOD group. +4 more findings

Full summary, score breakdown and related studies → Original source