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Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative
Juliana Nery Souza‐Talarico, Yelena Perkhounkova, Maria Hein, Jihye Lee, Marco M. Hefti, Shireen Sindi. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, 2025-07-01
Topic: Amyloid, tau and blood-test diagnosis
Abstract Allostatic load (AL), reflecting chronic stress, is linked to cognitive decline, but its role in the Alzheimer's disease (AD) continuum needs further study. We examined the relationship between AL, progression from mild cognitive impairment (MCI) to mild dementia due to AD, and AD biomarkers. We analyzed 385 MCI individuals over 36 months using Alzheimer's Disease Neuroimaging Initiative (ADNI) data. AL index (ALI) changes over 12 months were calculated using plasma neuroendocrine, immunological, and metabolic markers. AD biomarkers included plasma amyloid beta 42 (Aβ42), cerebrospinal fluid (CSF) Aβ1‐42, tau, and hippocampus volume. A one‐point ALI increase was associated with MCI conversion odds by 15%. ALI increased in those progressing to mild dementia due to AD and decreased in MCI stable participants. ALI increases were linked to high CSF tau, plasma Aβ42, and low CSF Aβ1‐42, moderated by age, APOE ε4, and baseline tau levels. AL may interact with age and genetic risk, impacting AD biomarkers and MCI progression. Highlights ALI increase raises MCI to AD conversion odds by 15%. ALI increases in those progressing to AD and decreases in stable participants. Higher ALI was linked to high CSF tau, plasma Aβ42, and low CSF Aβ1‐42 These associations were moderated by age, APOE ε4 status, and baseline CSF tau
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APA 7th
Souza‐Talarico, J. N., Perkhounkova, Y., Hein, M., Lee, J., Hefti, M. M., & Sindi, S. (2025). Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring. https://doi.org/10.1002/dad2.70140
Vancouver
Souza‐Talarico JN, Perkhounkova Y, Hein M, Lee J, Hefti MM, Sindi S. Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring. 2025. doi:10.1002/dad2.70140. PMID: 40606518.
BibTeX
@article{souzatalarico2025-40606518,
author = {Souza‐Talarico, Juliana Nery and Perkhounkova, Yelena and Hein, Maria and Lee, Jihye and Hefti, Marco M. and Sindi, Shireen},
title = {{Allostatic load dynamics, Alzheimer's disease biomarkers, and progression in individuals with mild cognitive impairment: findings from the Alzheimer's Disease Neuroimaging Initiative}},
journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
year = {2025},
doi = {10.1002/dad2.70140},
pmid = {40606518},
url = {https://doi.org/10.1002/dad2.70140}
}
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Key findings
- A one‐point ALI increase was associated with MCI conversion odds by 15%.
Why it matters
In 385 people with mild cognitive impairment, a one-point increase in allostatic load index was associated with 15% higher odds of conversion to mild dementia due to Alzheimer's disease. This is an observational association and does not test any treatment, cure or prevention.
Study details
- Participants385
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring: journal h-index 86 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 385 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Shireen Sindi: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Karolinska Institutet: institution h-index 1,477 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40606518) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/dad2.70140
- PubMed: 40606518
- Original source →
- Free full text: Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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