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Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis
Mathijs T. Rosbergen, Pieter J. van der Veere, Jacqueline Josephine Claus, Tavia E. Evans, Vikram Venkatraghavan, Frederik Barkhof, Argonde C. van Harten, M. Arfan Ikram et al.. Alzheimer s & Dementia, 2025-07-01
Topic: Risk, prevention and care in population studies
Plain-language summary
= 1661), 622 developed dementia within 5 years. Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk, independent of other subcortical structures. Smaller hippocampal volume was predominantly associated with the clinical diagnosis of Alzheimer's disease, but the prognostic value did not differ by amyloid status. Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis. HIGHLIGHTS: Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years. Hippocampal volume is associated with 5-year risk of dementia in subjective cognitive decline (SCD) or mild cognitive impairment (MCI). Amygdalar volume is associated with a 5-year risk of dementia in SCD or MCI. Stratifying by SCD and MCI revealed no consistent major differences.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rosbergen, M. T., van der Veere, P. J., Claus, J. J., Evans, T. E., Venkatraghavan, V., Barkhof, F., et al. (2025). Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70413
Vancouver
Rosbergen MT, van der Veere PJ, Claus JJ, Evans TE, Venkatraghavan V, Barkhof F, et al. Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70413. PMID: 40629712.
BibTeX
@article{rosbergen2025-40629712,
author = {Rosbergen, Mathijs T. and van der Veere, Pieter J. and Claus, Jacqueline Josephine and Evans, Tavia E. and Venkatraghavan, Vikram and Barkhof, Frederik and van Harten, Argonde C. and Ikram, M. Arfan and others},
title = {{Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70413},
pmid = {40629712},
url = {https://doi.org/10.1002/alz.70413}
}
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Key findings
- = 1661), 622 developed dementia within 5 years.
- Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk, independent of other subcortical structures.
- Smaller hippocampal volume was predominantly associated with the clinical diagnosis of Alzheimer's disease, but the prognostic value did not differ by amyloid status.
- Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis.
- HIGHLIGHTS: Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years.
Why it matters
In people with subjective cognitive decline or mild cognitive impairment, smaller hippocampus and amygdala volumes were linked to a higher risk of developing dementia within 5 years. This suggests these brain measures could help estimate a person's short-term dementia risk, though the study does not show that any treatment changes this risk.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 52/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 13 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 8.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Frank J. Wolters: h-index 46 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40629712) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
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