Newest studies

Model Predicting Positive Aspects of Caregiving Among Family Cares of Persons With Dementia: A Longitudinal Cohort Study

49/100 ✓ Peer-reviewed How common it is Journal of Advanced Nursing

Key finding: The carers aged 56.2 (SD = 12.2); about two-thirds being female and adult-child caregivers. +4 more findings

• Caregiving

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High-Throughput Phenotyping of the Symptoms of Alzheimer Disease and Related Dementias Using Large Language Models: Cross-Sectional Study

38/100 ✓ Peer-reviewed Brain scans and imaging JMIR AI

Key finding: Symptom extraction across the 7 domains achieved high accuracy with AUROCs ranging from 0.97 to 0.99. +4 more findings

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Unraveling the Genetic and Phenotypic Complexity of Down Syndrome from Trisomy 21 to Comorbid Conditions

25/100 ✓ Peer-reviewed Genetics International Journal of Genetics and Genomics

Key finding: Down syndrome (DS), caused by trisomy of chromosome 21, exhibits significant phenotypic variability, including intellectual disability, early-onset Alzheimer disease (AD), congenital heart defects (CHDs), haematological malignancies, and immune dysregulation. +4 more findings

• Genetics
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease

48/100 ✓ Peer-reviewed Biomarkers Acta Neuropathologica

Key finding: Strikingly, in proportion to total drug received, Aβ deposit AFs were significantly lower in the gantenerumab arm versus controls in almost all areas examined, including frontal, temporal, parietal, and occipital cortices, anterior cingulate, hippocampus, caudate, putamen, thalamus, and cerebellar gray matter; only posterior cingulate and cerebellar white matter comparisons were non-significant. +1 more finding

• Clinical Trials
• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

46/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Our findings reveal a hitherto relatively unexplored potential benefit of targeting extracellular MTBR/R' tau on correcting synaptic dysfunction.

• Brain Biology

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Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia

39/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Aging Neuroscience

Key finding: These mechanisms likely contribute to the acceleration of neurodegeneration in AD and the onset or worsening of depressive symptoms. +4 more findings

• Treatments

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Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies

41/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: Emerging evidence indicates that globus pallidus (GP) function can be modulated by orexin-A in movement disorders, while its role in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) remains unclear. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Development of a neural network-based risk prediction model for mild cognitive impairment in older adults with functional disability

46/100 ✓ Peer-reviewed Mild cognitive impairment BMC Public Health

Key finding: The results indicated that residence location, alcohol consumption, life satisfaction, depressive symptoms, and education level are key factors influencing the risk of MCI among older adults with functional disability. +2 more findings

• Early Stage
• Digital Tools

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Research progress in predicting the conversion from mild cognitive impairment to Alzheimer’s disease via multimodal MRI and artificial intelligence

43/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: Predicting the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) has important clinical significance for dementia prevention and improving patient prognosis. +3 more findings

• Digital Tools
• Brain Scans
• Early Stage

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Prevalence of Epilepsy in Frontotemporal Dementia and Timing of Dementia Diagnosis

58/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: The study cohort included 245 patients with FTD (121 female [49.4%], 124 male [50.6%]; mean [SD] age, 65.2 [8.7] years), 2416 matched HCs (1190 female [49.3%], 1226 male [50.7%]; mean [SD] age, 65.0 [8.5] years), and 1326 patients with AD (777 female [58.6%], 549 male [41.4%]; mean [SD] age, 71.7 [9.8] years). +4 more findings

• Diagnosis

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Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis

41/100 ✓ Peer-reviewed Treatments Acta Neuropathologica

Key finding: ABBV-916 significantly reduced dense plaques from brain tissue that were co-cultured with hiPSC-derived phagocytes. +3 more findings

• Brain Biology
• Treatments

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Neurofilament light chain and Alzheimer pathology biomarkers in elderly people with multiple sclerosis

41/100 ✓ Peer-reviewed Tau biomarkers Journal of the neurological sciences

Key finding: Neurofilament light chain (NfL) conventionally reflects disability worsening in multiple sclerosis (MS), but does not necessarily imply MS-specific mechanisms and could be affected by biological or pathological aging, including Alzheimer disease (AD) pathology. +3 more findings

• Biomarkers

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Generational Differences in Age-Specific Dementia Prevalence Rates

55/100 ✓ Peer-reviewed How common it is JAMA Network Open

Key finding: In this cross-sectional study examining generational differences in age-specific dementia prevalence across the US, Europe, and England, we found that individuals from more recent birth cohorts had lower proportions of people with dementia. +3 more findings

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Economic Impact of Dementia After Kidney Transplantation: A Matched Cohort Analysis

73/100 ✓ Peer-reviewed Costs and economics Clinical transplantation

Key finding: Dementia was diagnosed at a mean of 5.1 ± 3.4 years post-KTx. +4 more findings

• Policy

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Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial

82/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: There was no change in the primary outcome. +4 more findings

• Clinical Trials

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Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias

54/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images). +4 more findings

• Brain Scans

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GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia

59/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We found genome-wide significant signals for agitation, anxiety, apathy, delusions, and hallucinations that were driven by the apolipoprotein E (APOE) ε4 allele. +4 more findings

• Genetics
• Early Stage

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Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts

77/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma NfL and GFAP were associated with vascular brain damage and differed across states (VCI > vascular CU > non-vascular CI > non-vascular CU). +4 more findings

• Biomarkers

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Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Phosphorylation renders the PRD significantly resistant to cleavage by the lysosome, especially at less acidic pH setpoints. +4 more findings

• Biomarkers

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Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury

56/100 ✓ Peer-reviewed Vascular contributions Journal of Cachexia Sarcopenia and Muscle

Key finding: Sensitivity analyses were performed to validate the robustness of the linear regression results. +3 more findings

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Advance Care Planning on a Specialist Dementia Unit

30/100 ✓ Peer-reviewed End-of-life care BJPsych Open

Key finding: Number of patients on the unit with an ACP increased between May 2024 and January 2025, from a low of 0% on 03/06/24 to a high of 53% on 12/12/24. +4 more findings

• End-of-Life Care

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Guanfacine for the management of the behavioral manifestations of delirium in older hospitalized adults

46/100 ✓ Peer-reviewed Clinical safety Mental Health Clinician

Key finding: Upon initiation of guanfacine, patients with delirium had a reduction in daily antipsychotic exposure and a decrease in positive delirium screens. +3 more findings

• Side Effects
• Care Services

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Falls, Sleep Disorders and Cognitive Frailty in Hospitalized Older Adults with Hypertension:A Cross-Sectional Study

48/100 ✓ Peer-reviewed Clinical safety Clinical Interventions in Aging

Key finding: A total of 266 older adults with hypertension were surveyed in this study, of whom 108 reported having fallen once or more in the past year. +4 more findings

• Risk Factors
• Lifestyle
• Care Services

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The Role of Phytochemicals in Age-Related Cognitive Decline: A Natural Solution for Brain Health

35/100 ✓ Peer-reviewed Prevention trials Natural Product Communications

Key finding: Key compounds such as flavonoids, curcumin, resveratrol, and Ginkgo biloba derived compounds including; Ginkgolic Acids, terpenoids (Ginkgolides and Bilobalide), have demonstrated potential in reducing oxidative stress, modulating neuroinflammation, enhancing mitochondrial function, and improving neurotransmitter balance.

• Brain Biology
• Lifestyle

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Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays

43/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: LLMD participants were more likely to be tau PET and Aβ PET positive than HCs. +4 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source