alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,351–16,375 of 27,380 studies, newest first · page 655 of 1096.

February 2016 3

  1. 2016-02-01

    Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

    ✓ Peer-reviewed Genetics JAMA

    Key finding: Among the 286 autopsied brains of 544 participants, brain mercury levels were positively correlated with the number of seafood meals consumed per week (ρ = 0.16; P = .02). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-02-01

    Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

    ✓ Peer-reviewed Biomarkers Anesthesiology

    Key finding: Low CSF Aβ1-42 may be a significant predictor of POCD at 3 months. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2016-02 month only

    Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

    ✓ Peer-reviewed Prevention and risk Diabetes Care

    Key finding: Diabetes was linked to about a 60% higher risk of any dementia in both women (RR 1.62) and men (RR 1.58) +3 more findings

    Full summary, score breakdown and related studies → Original source

January 2016 22

  1. 2016-01-30

    Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

    ✓ Peer-reviewed Risk factors Environmental research

    Key finding: Millions of urban children are chronically exposed to high concentrations of air pollutants, i.e., fine particulate matter (PM2.5) and ozone, associated with increased risk for Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-01-29

    Increased CSF neurogranin concentration is specific to Alzheimer disease

    ✓ Peer-reviewed Digital health tools Neurology

    Key finding: An optimized immunoassay was used to analyze CSF Ng in a retrospective cohort of 331 participants with different neurodegenerative diseases, including healthy controls (n = 19), biomarker-proven Alzheimer disease (AD) (n = 100), genetic AD (n = 2), behavioral variant frontotemporal dementia (n = 20), speech variant frontotemporal dementia (n = 21), Lewy body dementia (n = 13), Parkinson disease (n = 31), progressive supranuclear palsy (n = 46), multiple system atrophy (n = 29), as well as a heterogeneous group with non-neurodegenerative cognitive impairment (n = 50).

    Full summary, score breakdown and related studies → Original source

  3. 2016-01-29

    Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease

    ✓ Peer-reviewed Caregiving Alzheimer's research & therapy

    Key finding: The primary outcome of this trial was negative. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-01-28

    Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans: Results from a Phase-3 Study

    ✓ Peer-reviewed End-of-life care Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Florbetaben scans were assessed visually and quantitatively, and results were compared with amyloid plaque scores. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2016-01-28

    Brain atrophy in Alzheimer's Disease and aging

    ✓ Peer-reviewed Brain scans and imaging Ageing research reviews

    Key finding: Disease progression has also been associated with changes in white matter tracts. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2016-01-27

    Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment

    ✓ Peer-reviewed Genetics Frontiers in neuroscience

    Key finding: We developed the Expression Weighted Cell Type Enrichment (EWCE) method that uses single cell transcriptomes to generate the probability distribution associated with a gene list having an average level of expression within a cell type. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2016-01-27

    Higher brain BDNF gene expression is associated with slower cognitive decline in older adults

    ✓ Peer-reviewed Brain tissue and pathology Neurology

    Key finding: We tested whether brain-derived neurotrophic factor (BDNF) gene expression levels are associated with cognitive decline in older adults. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2016-01-26

    Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

    ✓ Peer-reviewed Biomarkers Frontiers in Aging Neuroscience

    Key finding: Our findings show that KTP-derivatives, mainly IbKTP-NH2, enhanced cognitive impairment of 2VO-animals and prevented neuronal damage in hippocampal CA1 subfield, suggesting their potential usefulness for the treatment of dementia.

    Full summary, score breakdown and related studies → Original source

  9. 2016-01-26

    Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia

    ✓ Peer-reviewed Genetics Molecular psychiatry

    Key finding: Substantial and significant genetic correlations were observed between cognitive test scores in the UK Biobank sample and many of the mental and physical health-related traits and disorders assessed here. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2016-01-26

    Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

    Key finding: The 52 baseline participants comprised autosomal dominant Alzheimer's disease mutation carriers (n = 11; 49.6 ± 10.3 years old) and non-carriers (n = 16; 51.1 ± 14.2 years old; 10 male), and patients with sporadic mild cognitive impairment (n = 17; 61.9 ± 6.4 years old; nine male) and sporadic Alzheimer's disease (n = 8; 63.0 ± 6.5 years old; five male); for confidentiality reasons, the gender of mutation carriers is not revealed. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2016-01-26

    Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial

    ✓ Peer-reviewed Treatments Annals of internal medicine

    Key finding: Disclosure of pleiotropic information did not increase anxiety or depression and may have decreased distress among persons at increased risk for 2 conditions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2016-01-25

    A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

    ✓ Peer-reviewed Brain scans and imaging PloS one

    Key finding: This can impair performance in behavioral tests that rely on visual cues, and thus, affect study results.

    Full summary, score breakdown and related studies → Original source

  13. 2016-01-25

    Updated TDP-43 in Alzheimer's disease staging scheme

    ✓ Peer-reviewed Lewy body dementia Acta neuropathologica

    Key finding: The conditional probability analysis produced six significantly different stages (P < 0.01), and suggests that TDP-43 deposition begins in the amygdala (stage 1), then moves to entorhinal cortex and subiculum (stage 2); to the dentate gyrus of the hippocampus and occipitotemporal cortex (stage 3); insular cortex, ventral striatum, basal forebrain and inferior temporal cortex (stage 4); substantia nigra, inferior olive and midbrain tectum (stage 5); and finally to basal ganglia and middle frontal cortex (stage 6). +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2016-01-25

    Computer-based cognitive interventions for people living with dementia: a systematic literature review and meta-analysis

    ✓ Peer-reviewed Disparities Aging & mental health

    Key finding: Twelve studies were identified. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2016-01-25

    Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: Factors impacting on time to diagnosis vary with the stage of diagnosis in YOD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-01-23

    Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

    ✓ Peer-reviewed End-of-life care Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2016-01-22

    Factors Associated with Unmet Needs among African-American Dementia Care Providers

    ✓ Peer-reviewed Disparities Journal of gerontology & geriatric research

    Key finding: As a result, Alzheimer's disease (AD), the 5th leading cause of death for people aged 65 and older, is likely to increase in these groups.

    Full summary, score breakdown and related studies → Original source

  18. 2016-01-22

    Effectiveness of interventions to directly support food and drink intake in people with dementia: systematic review and meta-analysis

    ✓ Peer-reviewed Clinical safety BMC geriatrics

    Key finding: We found no definitive evidence on effectiveness, or lack of effectiveness, of specific interventions but studies were small and short term. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2016-01-22

    Stroke injury, cognitive impairment and vascular dementia

    ✓ Peer-reviewed Prevention and risk Biochimica et biophysica acta

    Key finding: Current evidence suggests that 25-30% of ischaemic stroke survivors develop immediate or delayed vascular cognitive impairment (VCI) or vascular dementia (VaD).

    Full summary, score breakdown and related studies → Original source

  20. 2016-01-21

    Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: We believe that ours is the largest blood biomarker study of preclinical AD to date. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2016-01-21

    TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

    ✓ Peer-reviewed TREM2 and immune genetics Neuropharmacology

    Key finding: Emerging evidence indicates a strong association between TREM2 and tau pathology in the cerebral spinal fluid or brain tissue of AD patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2016-01-20

    Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: We show that inhibition of γ-secretase-dependent cleavage of the TREM2 C-terminal fragment in cellular membranes interferes with TREM2-dependent signaling and cellular function. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →