Newest studies

Dissecting the genetic and proteomic risk factors for delirium

66/100 ✓ Peer-reviewed Genetics Nature Aging

Key finding: Delirium is an acute change in cognition, common in hospitalized older adults, and associated with high healthcare and human cost; however, delirium's genetic and proteomic background remains poorly understood. +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia

54/100 ✓ Peer-reviewed Laboratory science Nature Neuroscience

Key finding: Using a human microglia xenograft mouse model, we show that Lecanemab significantly reduces Aβ pathology and associated neuritic damage, while neither fragment crystallizable (Fc)-silenced Lecanemab nor microglia deficiency elicits this effect despite intact plaque binding. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study

49/100 ✓ Peer-reviewed Treatments BMC Neurology

Key finding: Overall, 392 patients were enrolled in HARMONY; 49 patients with PDD and 27 patients with DLB were included in the open-label safety analysis, of whom 46 met response criteria and were randomized to receive pimavanserin (n = 22) or placebo (n = 24) during the double-blind period. +3 more findings

• Clinical Trials
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association Between Long-Term Care Insurance Certification and Early Home-Visit Nursing Frequency in Older Patients With Heart Failure in Japan

32/100 ✓ Peer-reviewed Health systems and care delivery Home Health Care Management & Practice

Key finding: This study examined whether LTCI certification is associated with the frequency of early home-visit nursing. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders

46/100 ✓ Peer-reviewed Risk genes beyond APOE Autophagy

Key finding: The unique spatial and functional demands of neurons result in differences in the regulation of metabolic, autophagic, mitophagic and biosynthetic processes compared to other cell types.

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Blood biomarkers of Alzheimer’s disease and progression across different stages of cognitive decline in the community

52/100 ✓ Peer-reviewed Mild cognitive impairment Nature Communications

Key finding: Lower amyloid-β42/40 ratio and higher phosphorylated-tau181 (p-tau181), p-tau217, total-tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were associated with faster progression from MCI to all-cause and AD dementia, with the strongest associations for NfL and p-tau217. +2 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Association of neighborhood disadvantage with Alzheimer's disease pathology and the stability of blood-based biomarker performance

51/100 ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

Key finding: ADI groups differed by sex, ethnoracial background, and MMSE scores. +4 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Multidomain therapy for Alzheimer’s disease: a scoping review of cognitive decline trials

52/100 ✓ Peer-reviewed Prevention trials Molecular Neurodegeneration

Key finding: There have been 23 studies (completed or reported as ongoing) of multidomain interventions for AD, including 19 RCTs. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

The moderated mediation effect of caregiving stress and social support in the relationship between behavioral and psychological symptoms of dementia and caregiver burden in Oman: a cross-sectional study

43/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: The proposed model demonstrated a sound fit (PCMIN/DF = 2.612). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China

43/100 ✓ Peer-reviewed Prevention trials Journal of sport and health science

Key finding: Animal exercise intervention studies are widely used and provide valuable scientific evidence about the cellular and molecular mechanisms underlying the effects of exercise training in a variety of chronic disease models. +4 more findings

• Prevention
• Lifestyle
• Treatments

Full summary, score breakdown and related studies → Original source

Data-driven modeling of amyloid-β targeted antibodies for Alzheimer's disease

45/100 ✓ Peer-reviewed Treatments NPJ systems biology and applications

Key finding: Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta, which is strongly associated with disease progression and cognitive decline. +2 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts

57/100 ✓ Peer-reviewed Vascular contributions Annals of Neurology

Key finding: In ARIC (n = 1,736, mean age 63, 58.8% female, 48.7% non-Hispanic White individuals, median follow-up 18.6 years), the dementia incidence rate was 10.4 (95% CI, 9.2-11.6) per 1,000 person-years. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

The Cognitive Functions in Patients With Postoperative Delirium Undergoing Cardiac Surgery After ICU Discharge

52/100 ✓ Peer-reviewed Clinical safety Dimensions of Critical Care Nursing

Key finding: Eight studies reported evidence of level 3 (OCEBM level), and 4 had high methodological quality (JBI score). +4 more findings

Full summary, score breakdown and related studies → Original source

Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes

37/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Flow cytometry and confocal microscopy revealed the accumulation of particles of both sizes within the cytoplasm. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Endogenous Lithium Levels and Alzheimer Disease

31/100 ✓ Peer-reviewed Treatments Clinical Chemistry

Key finding: The pathophysiology of AD remains poorly understood, with multifactorial etiology (age, genetics, environmental, and lifestyle factors). +4 more findings

• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Alzheimer Disease Blood Biomarker Concentrations Across Race and Ethnicity Groups in Middle-Aged Adults

64/100 ✓ Peer-reviewed Biomarkers JAMA Network Open

Key finding: The sample included 4340 adults (mean [SD; range] age, 58.1 [1.1; 56-63] years; 2400 [55.3%] women); 630 (14.4%) were Black, 900 (20.7%) were Latinx, and 2610 (60.1%) were White. +4 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Proteome Signature of Alzheimer-Like Phenotypes in Frontal Cortices From Young and Old Individuals With Down Syndrome

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular neurobiology

Key finding: Notably, individuals with DS exhibit significant neuropathological changes for a diagnosis of Alzheimer's disease (AD), typically by the age of 50 years. +3 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE-/- Mice by Regulating M1/M2 Microglial Polarization

43/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: Our previous study indicated that TREM2 promoted microglia polarization to the M2 phenotype in APP/PS1 transgenic mice and BV2 cells. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

[Optimization of the work of outpatient memory clinics from the perspective of value-based healthcare-An approach from the Clinic for Psychiatry and Psychotherapy of the ZI Mannheim]

39/100 ✓ Peer-reviewed Health systems and care delivery Der Nervenarzt

Key finding: The results from both surveys were compared using t‑tests or Mann-Whitney U tests. +2 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

52/100 ✓ Peer-reviewed Vascular contributions Nature Aging

Key finding: Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. +1 more finding

• Biomarkers
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Effectiveness of a 52-week multidomain intervention to maintain cognitive function in patients with mild cognitive impairment: a randomized controlled trial

55/100 ✓ Peer-reviewed Prevention trials Scientific Reports

Key finding: We found a positive effect of the multidomain intervention using a mobile application on the change in cognitive function score in the intervention group compared to the control group at the 52-week follow-up. +2 more findings

• Clinical Trials
• Early Stage
• Prevention

Full summary, score breakdown and related studies → Original source

Seeding biosensor cell line that reproduces the Alzheimer tau fold

41/100 ✓ Peer-reviewed Disease mechanisms Journal of Biological Chemistry

Key finding: Our results establish a sensitive biosensor cell line with specificity toward seeds from 3R + 4R tauopathies.

Full summary, score breakdown and related studies → Original source

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

43/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer s Research & Therapy

Key finding: M1 specifically enhanced uptake of Aβ fibrils through reduction of intracellular cAMP levels, without affecting monomeric or oligomeric Aβ internalization. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Impact of assistive technologies on caregiver burden and perseverance for people with dementia at home

34/100 ✓ Peer-reviewed Caregiving Health Policy and Technology

Key finding: An online survey of 342 informal caregivers in the Netherlands assessed objective burden (tasks and time involved in caregiving), subjective burden (personal experience of stress and strain), current perseverance time (time expected to be able to continue providing care), and well-being (overall happiness). +3 more findings

• Digital Tools
• Caregiving

Full summary, score breakdown and related studies → Original source

EARLY STAGES OF ALZHEIMERS DETECTION

39/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: The model is trained to recognize subtle patterns in the brain—such as structural shrinkage, texture changes, and abnormalities—associated with Alzheimer’s progression. +2 more findings

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source