Newest studies

Mapping the research landscape of Mild Cognitive Impairment in Parkinson's disease: a bibliometric and visualization analysis

43/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

Key finding: Mild cognitive impairment in Parkinson's disease research has progressed from basic mechanism exploration to a multidisciplinary, integrated clinical-basic stage, following an evolutionary path of "pathological mechanism - clinical phenotype - biomarker - intervention strategy." +1 more finding

• Early Stage
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Tongxinluo capsule in the treatment of cerebral small vessel disease: protocol of a randomised, double-blind, placebo-controlled, multicentre clinical study (TOPS-CSVD)

48/100 ✓ Peer-reviewed Vascular contributions Stroke and Vascular Neurology

Key finding: The primary outcome of this clinical trial is the change in the Vascular Dementia Assessment Scale-cognitive subscale from baseline to 12 months. +2 more findings

• Clinical Trials
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Machine Learning Prediction of Agitation in Dementia Patients Using Sleep and Physiological Data

33/100 ✓ Peer-reviewed Digital health tools Applied Sciences

Key finding: This behavior contributes to heightened distress and increased risk of harm for patients, while posing a significant burden for caregivers, who must navigate the complexities of managing unpredictable and potentially harmful agitation episodes. +1 more finding

• Digital Tools
• Lifestyle

Full summary, score breakdown and related studies → Original source

Neurofilament Light Chain and Differentiation of Behavioral Variant Frontotemporal Dementia From Psychiatric Disorders

63/100 ✓ Peer-reviewed Getting a diagnosis JAMA Psychiatry

Key finding: A total of 3828 titles and abstracts and 434 full-text articles were reviewed, yielding 12 articles meeting eligibility criteria. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv : the preprint server for biology

Key finding: The strongest genetic AD risk factor, APOE4, is associated with cerebrovascular degeneration, including vascular amyloid deposition and fibrosis. +1 more finding

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers

43/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: While accounting for renal function may improve specificity, it could reduce sensitivity without greatly changing overall diagnostic accuracy.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cognitive and Psychosocial Effects of Individual Cognitive Stimulation in Dementia: A Randomized Controlled Trial

52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Psychosocial Rehabilitation and Mental Health

Key finding: This study aimed to evaluate the impact of a year-long, home-based individual cognitive stimulation (iCS) program on cognitive performance, mood, functional independence, and quality of life (QoL) in older adults with mild Alzheimer’s disease and vascular dementia. +1 more finding

• Clinical Trials
• Diagnosis
• Lifestyle

Full summary, score breakdown and related studies → Original source

Supporting Informal Dementia Caregivers Through an iSupport Web-Based Primary Health Care Intervention: Hybrid Effectiveness-Implementation Mixed Methods Study

60/100 ✓ Peer-reviewed Caregiving Journal of Medical Internet Research

Key finding: The intervention revealed no substantial between-group differences in caregiver burden (β=-3.80, 95% CI -11.25 to 3.65, P=.32), quality of life (β=-1.55, 95% CI -6.59 to 3.49, P=.55), or social support (β=0.85, 95% CI -2.86 to 4.56, P=.65). +4 more findings

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Exploring the unmet needs of Latino dementia caregivers: a qualitative study

43/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Four themes were derived from the data analysis as key areas of caregiving needs for Latinos: need to connect socially with others; need for resources to provide care; need to understand dementia and navigating existing resources and future care planning; and need for empathic, culturally congruent healthcare. +2 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Use of a Screening Tool for Dementia in a Down Syndrome Specialty Clinic

40/100 ✓ Peer-reviewed Getting a diagnosis American Journal of Medical Genetics Part A

Key finding: Lower thresholds (e.g., ≥ 1) captured all true positives but at the cost of many false positives, whereas higher thresholds (e.g., ≥ 20) improved specificity and positive predictive value, identifying fewer individuals overall but with greater diagnostic confidence.

• Diagnosis
• Down Syndrome

Full summary, score breakdown and related studies → Original source

The 2024 UK clinical guideline for the prevention and treatment of osteoporosis

67/100 ✓ Peer-reviewed Prevention and risk Archives of Osteoporosis

Key finding: Review of the evidence and recommendations are provided for the diagnosis of osteoporosis, fracture-risk assessment and intervention thresholds, management of vertebral fractures, non-pharmacological and pharmacological treatments, including duration and monitoring of anti-resorptive therapy, glucocorticoid-induced osteoporosis, as well as models of care for fracture prevention. +4 more findings

• Prevention
• Treatments

Full summary, score breakdown and related studies → Original source

Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology

63/100 ✓ Peer-reviewed Genetics JAMA Neurology

Key finding: In a total of 602 autopsy cases (median [IQR] age at death, 78 [71-85] years; 328 male [54.5%] and 274 female [45.5%]), higher PM2.5 exposure prior to death was associated with increased odds of more severe Alzheimer disease neuropathologic change (ADNC) (odds ratio, 1.19; 95% CI, 1.11-1.28). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association Between In-Hospital Applications for Long-Term Care Services and Hospital Length of Stay Among Older Adults: Ecological Cross-Sectional Study

33/100 ✓ Peer-reviewed Health systems and care delivery JMIR Formative Research

Key finding: The median proportion of in-hospital LTC certification applications was 30.5% (IQR 24.5%-36.1%). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

α-Synuclein Seed Amplifications Assay in a Cohort With Cognitive Impairment: Performance and Interactions With CSF and Plasma Biomarkers

59/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: α-Synuclein seed amplification assays (αSAAs) can improve the diagnosis of synucleinopathies and detect α-synuclein (αSyn) copathology in vivo in clinical practice. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Preclinical dementia rating scores are associated with plasma phosphorylated tau-217

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Higher baseline pTau217 levels were associated with faster functional (QDRS) and cognitive (PACC3) decline. +3 more findings

Full summary, score breakdown and related studies → Original source

Race-Specific Impact of Telehealth Advance Care Planning on Cost of Dementia: A Cost Prediction Study

41/100 ✓ Peer-reviewed End-of-life care International Journal of Environmental Research and Public Health

Key finding: The aim of this study is to predict healthcare cost savings associated with delivering telehealth advance care planning (ACP) to patients living with dementia. +3 more findings

• End-of-Life Care
• Policy
• Digital Tools

Full summary, score breakdown and related studies → Original source

Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies

39/100 ✓ Peer-reviewed Clinical safety Parkinsonism & Related Disorders

Key finding: Twenty-nine individuals were enrolled, 3 were women (10.3 %), age 76.3 ± 6 years (mean ± SD). +4 more findings

• Side Effects
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association Between Dietary Biotin Intake and Dementia Risk, Including Alzheimer's Disease: A Prospective Study of 122 959 UK Biobank Participants

40/100 ✓ Peer-reviewed Long-term cohort studies Molecular Nutrition & Food Research

Key finding: Cox proportional hazards models showed that compared to the lowest biotin intake (Q1), biotin reduced the risk of all-cause dementia (HR: 0.75[0.64,0.88] p < 0.001 for Q2; HR: 0.68[0.58,0.81] p < 0.001 for Q3; HR: 0.67[0.56,0.81] p < 0.001 for Q4) and Alzheimer's disease (AD) (HR: 0.74[0.58,0.96] p = 0.026 for Q2; HR: 0.65[0.49,0.85] p = 0.002 for Q3). +3 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Socio-Demographic Factors Linked to Psychological Well-Being in Dementia Caregivers

42/100 ✓ Peer-reviewed Caregiving Healthcare

Key finding: Caregivers reported moderate to high well-being scores, with Environmental Mastery highest (M = 38.01, SD = 8.70) and Purpose in Life lowest (M = 33.14, SD = 6.72). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease

81/100 ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease

Key finding: A total of 210 participants were enrolled and 82% completed 26 weeks of treatment. +4 more findings

• Clinical Trials
• Side Effects
• Biomarkers

Full summary, score breakdown and related studies → Original source

TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential

43/100 ✓ Peer-reviewed TREM2 and immune genetics Cells

Key finding: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), represent significant global health challenges, affecting millions and straining healthcare systems.

• Genetics
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Descobertas e avanços do sequenciamento de próxima geração na doença de Alzheimer

27/100 ✓ Peer-reviewed Risk genes beyond APOE BioSCIENCE

Key finding: Resultado: NGS identificou genes como APP, TREM2 e PLD3, juntamente com modificações epigenéticas ligadas à DA. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Regional differences in the incidence of Alzheimer’s disease and related dementias in South Carolina

43/100 ✓ Peer-reviewed How common it is Frontiers in Neurology

Key finding: Regional differences in the incidence of ADRD suggest possible disparities in healthcare access, socioeconomic conditions and geographical factors. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Muti-band Morlet mutual information functional connectivity for classifying Alzheimer's disease and frontotemporal dementia with a deep learning technique

38/100 ✓ Peer-reviewed Getting a diagnosis Computers in Biology and Medicine

Key finding: In FTD analysis, graph theory metrics were also reduced in the delta and theta bands, with the delta band showing the most pronounced group differences compared to HC.

• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Accuracy of the Mini-Mental State Examination and Montreal Cognitive Assessment in Detecting Cognitive Impairment in Older Adults: A Comparative Study Adjusted for Educational Level

48/100 ✓ Peer-reviewed Getting a diagnosis NeuroSci

Key finding: Cognitive performance was assessed using the MMSE and MoCA, with results analyzed using both standard and education-adjusted cut-off scores. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source