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Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers
Burak Arslan, Henrik Zetterberg, Nicholas J Ashton. Journal of Alzheimer's disease : JAD, 2025-09-09
Topic: Plasma and spinal-fluid biomarkers
As plasma biomarkers like p-tau217 move towards clinical use in Alzheimer's disease (AD), it is important to understand how kidney function may influence their accuracy. Even mild chronic kidney disease (CKD) can alter biomarker levels, potentially impacting test performance. While accounting for renal function may improve specificity, it could reduce sensitivity without greatly changing overall diagnostic accuracy. Most studies focus on mild CKD, leaving gaps in understanding severe CKD-especially in real-world settings like primary care. Including renal indices such as eGFR in diagnostic models could help improve interpretation and minimize misclassification in older adults, where CKD is common.
Key findings
- While accounting for renal function may improve specificity, it could reduce sensitivity without greatly changing overall diagnostic accuracy.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40924619) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Arslan, B., Zetterberg, H., & Ashton, N. J. (2025). Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers. Journal of Alzheimer's disease : JAD. https://doi.org/10.1177/13872877251375101
Vancouver
Arslan B, Zetterberg H, Ashton NJ. Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers. Journal of Alzheimer's disease : JAD. 2025. doi:10.1177/13872877251375101. PMID: 40924619.
BibTeX
@article{arslan2025-40924619,
author = {Arslan, Burak and Zetterberg, Henrik and Ashton, Nicholas J},
title = {{Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2025},
doi = {10.1177/13872877251375101},
pmid = {40924619},
url = {https://doi.org/10.1177/13872877251375101}
}