Newest studies

Altered glymphatic function and cerebrovascular reactivity in white matter hyperintensities: Insights into cognitive impairment

42/100 ✓ Peer-reviewed Vascular contributions Brain Research Bulletin

Key finding: The ALPS-index showed a stepwise decline with increasing WMH severity and cognitive impairment (p < 0.001). +4 more findings

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UCH-L1 in Alzheimer’s Disease: A Crucial Player in Dementia-Associated Mechanisms

41/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: These findings underline UCH-L1's centrality in maintaining the homeostasis of protein folding and aggregation, which are significantly impaired in AD and AD-related dementias.

• Brain Biology

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The analysis of the gut microbiome during liver disease progression led to the identification of biomarkers for related mild cognitive impairment

40/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Microbiology

Key finding: could serve as potential biomarkers for NAFLD-associated mild cognitive impairment; 3) bacterial metabolic functions involved in sugar degradation and the breakdown of tryptophan and glutamate were downregulated and linked to CXCL13 plasma levels and neuroinflammation; 4) correlations between SCFA concentrations disappeared with liver disease and cognitive impairment. +2 more findings

• Early Stage
• Biomarkers

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The Association between Glaucoma and Dementia in a National Cohort of All of Us Participants

56/100 ✓ Peer-reviewed How common it is Ophthalmology

Key finding: Among the 393 497 All of Us participants with linked EHRs, we identified 9444 individuals (2.40%) with glaucoma diagnoses (excluding participants with diagnoses of dementia before glaucoma) and 37 776 matched controls without glaucoma. +4 more findings

• Risk Factors

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Dementia in primary care: a qualitative study with general practitioners and caregivers with and without migration backgrounds

32/100 ✓ Peer-reviewed Caregiving BMC Family Practice

Key finding: The analysis revealed six main themes: 'Core health care challenges,' 'communication approaches and information sharing,' 'role of GP,' 'situation of caregivers,' 'influence on caregiver-GP relationship,' and 'socio-cultural barriers and care preferences'. +4 more findings

• Caregiving

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Determinants of Treatment Willingness and Willingness-to-Pay for Lecanemab in China

30/100 ✓ Peer-reviewed Treatments Alzheimer Disease & Associated Disorders

Key finding: W treat showed a strong direct association with W cost (0.99). +4 more findings

• Treatments

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Microbiota-gut-brain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets

59/100 ✓ Peer-reviewed Disease mechanisms Molecular biomedicine

Key finding: Emerging evidence suggests that dysregulation of the MGBA plays pivotal roles in the onset and progression of neurodegenerative diseases. +1 more finding

• Brain Biology
• Treatments

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Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits

43/100 ✓ Peer-reviewed Genetics Neurobiology of disease

Key finding: In the SAA-APP knock-in model of dense-cored Aβ deposits resulting from accumulation of protofibrillar-favoring Aβ42, we observed that crossing in human APOE reduced amyloid burden. +4 more findings

• Genetics
• Brain Biology

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Anti-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Evidence, ARIA Risk, and Precision Patient Selection

45/100 ✓ Peer-reviewed Treatments Journal of personalized medicine

Key finding: Anti-amyloid mAbs consistently demonstrated robust amyloid clearance and modest slowing of clinical decline in early symptomatic AD. +4 more findings

• Treatments
• Side Effects
• Genetics

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Primary care detection of Alzheimer's disease using a self-administered digital cognitive test and blood biomarkers

62/100 ✓ Peer-reviewed Cognitive tests and assessment Nature medicine

Key finding: In primary care, BioCog had an accuracy of 85% when using a single cutoff to define cognitive impairment, which was significantly better than the assessment of primary care physicians (accuracy 73%). +3 more findings

• Diagnosis
• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

Utilization of Occupational and Physical Therapy Home Health Visits Among People Living With Dementia With Varying Social Determinants of Health

32/100 ✓ Peer-reviewed Risk factors Journal of the American Medical Directors Association

Key finding: We sought to identify patterns in occupational therapy (OT) and physical therapy (PT) home health care visits among people living with dementia (PLWD) by (1) level of function care partner report compared with administrative data, (2) race and ethnicity, and (3) level of socioeconomic resources. +2 more findings

• Health Equity
• Treatments
• Care Services

Full summary, score breakdown and related studies → Original source

BDNF Val66Met Genotype, DNA Methylation, mRNA, and Protein Levels as Potential Blood-Based Biomarkers for Dementia and Cognitive Decline

35/100 ✓ Peer-reviewed Cognitive tests and assessment International Journal of Molecular Sciences

Key finding: An insignificant decline in BDNF mRNA levels in dementia patients positively correlated with significantly lower BDNF plasma levels, especially pronounced in severe dementia patients. +2 more findings

• Biomarkers
• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study

61/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: We found a significant association between all-cause dementia and multimarker CSVD scores, which was independent of the FSRP as well as its individual components. +2 more findings

• Risk Factors

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Incretin Hormones GLP-1 and GIP Normalize Energy Utilization and Reduce Inflammation in the Brain in Alzheimer's Disease and Parkinson's Disease: From Repurposed GLP-1 Receptor Agonists to Novel Dual GLP-1/GIP Receptor Agonists as Potential Disease-Modifying Therapies

43/100 ✓ Peer-reviewed Drug development CNS drugs

Key finding: A recent phase III trial testing exendin-4 did not show an improvement, which may be linked to the lack of insulin desensitization in the study participants. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms

39/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer s Disease

Key finding: Advances in single-cell transcriptomics and lipidomics have revealed glial heterogeneity and novel molecular targets, including disease-associated microglia. +1 more finding

• Brain Biology
• Treatments
• Genetics

Full summary, score breakdown and related studies → Original source

Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults

62/100 ✓ Peer-reviewed Brain tissue and pathology JAMA Network Open

Key finding: Among 13 592 participants (mean [SD] age, 58.34 [9.39] years; 7175 [52.8%] female), 6525 (48.0%) experienced possible childhood loneliness, and 565 (4.2%) reported childhood loneliness. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Multi-domain synthetic medical image generation and dataset balancing with DGAN-WP-TL

32/100 ✓ Peer-reviewed Brain scans and imaging Computer Methods in Biomechanics and Biomedical Engineering Imaging & Visualization

Key finding: Imbalanced medical datasets significantly impair the performance of diagnostic models by biasing predictions towards majority classes.

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Visual Classification of Tau-PET Detects 4 Subtypes With Different Long-Term Outcomes

46/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: < 0.001), with the automated approach more likely to classify a scan as tau negative and lower agreement between methods in more severe cases and AD clinical variants. +3 more findings

• Brain Scans

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Dementia Dialogue: An Educational Workshop for Medical Students

32/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: The workshop significantly increased students' comfort with dementia care topics and knowledge of dementia and delirium.

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Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes

52/100 ✓ Peer-reviewed Lewy body dementia Neurology

Key finding: AAS perception stratifies FTD syndromes and constitutes a "real-world audiogram" in these diseases.

• Other Dementias

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Using Wearable Sensors to Measure and Predict Personal Circadian Lighting Exposure in Nursing Home Residents: Model Development and Validation

37/100 ✓ Peer-reviewed Digital health tools JMIR Aging

Key finding: The calibration models for photopic lux and correlated color temperature demonstrated strong accuracy, with an adjusted R² of 0.858 and 0.982, respectively, ensuring reliable sensor measurements. +4 more findings

• Digital Tools

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Social exposome and brain health outcomes of dementia across Latin America

60/100 ✓ Peer-reviewed Disparities Nature Communications

Key finding: Multiple sensitivity analyses confirm our results.

• Health Equity

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Artificial Intelligence–Powered Quantification of Flortaucipir PET for Detecting Tau Pathology

50/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: The AI-powered pipeline achieved robust performance with intraclass correlation coefficients exceeding 0.97 for regional uptake estimation compared with MR-based ground truth. +4 more findings

• Brain Scans
• Diagnosis
• Digital Tools

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Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study

53/100 ✓ Peer-reviewed Genetics Arteriosclerosis Thrombosis and Vascular Biology

Key finding: Overall, 430 093 participants were included. +4 more findings

• Genetics

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Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort

66/100 ✓ Peer-reviewed Disease mechanisms Microorganisms

Key finding: To address this research gap in the literature and to suggest novel microbiome features associated with MCI, we conducted a cross-sectional study in a European population sample and profiled gut microbiota in 99 individuals without dementia through 16s ribosomal RNA (rRNA) sequencing. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source